Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm.

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Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm. is …
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scholarly articleQ13442814

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P819ADS bibcode2006PNAS..103.9601W
P356DOI10.1073/PNAS.0506468103
P8608Fatcat IDrelease_x4xopdxqyvhoffwcy4jy5lury4
P932PMC publication ID1480453
P698PubMed publication ID16766665
P5875ResearchGate publication ID7016160

P50authorEthylin Wang JabsQ16226714
Irene Tiemann-BoegeQ55091116
P2093author name stringN Arnheim
B Eskenazi
S Young
R L Glaser
A J Wyrobek
D Evenson
F S Pearson
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Sperm chromatin structure assay (SCSA) parameters are related to fertilization, blastocyst development, and ongoing pregnancy in in vitro fertilization and intracytoplasmic sperm injection cyclesQ35769849
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NOVP chemotherapy for Hodgkin's disease transiently induces sperm aneuploidies associated with the major clinical aneuploidy syndromes involving chromosomes X, Y, 18, and 21.Q44272033
The effect of advancing paternal age on pregnancy and live birth rates in couples undergoing in vitro fertilization or gamete intrafallopian transferQ44784392
Influence of deoxyribonucleic acid damage on fertilization and pregnancyQ44831863
Germline origins in the human F9 gene: frequent G:C-->A:T mosaicism and increased mutations with advanced maternal age.Q45864823
Female and male partner age and menotrophin requirements influence pregnancy rates with human menopausal gonadotrophin therapy in combination with intrauterine inseminationQ46108685
The association of age and semen quality in healthy men.Q46954552
The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI.Q47673503
The influence of paternal age on down syndromeQ47880376
Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse.Q49083961
Sperm chromatin damage impairs human fertility. The Danish First Pregnancy Planner Study Team.Q50565378
Paternal age effect of YY aneuploidy in human sperm, as assessed by fluorescence in situ hybridization.Q50923914
Three-probe fluorescence in situ hybridization to assess chromosome X, Y, and 8 aneuploidy in sperm of 14 men from two healthy groups: evidence for a paternal age effect on sperm aneuploidy.Q51022490
Non-disjunction in human sperm: evidence for an effect of increasing paternal age.Q51032709
Single-Molecule Analysis of the Hypermutable Tetranucleotide Repeat Locus D21S1245 Through Sperm Genotyping: A Heterogeneous Pattern of Mutation but no Clear Male Age EffectQ52955736
Relationship between the outcomes of assisted reproductive techniques and sperm DNA fragmentation as measured by the sperm chromatin structure assayQ53816967
Frequency and parental origin of de novo APC mutations in familial adenomatous polyposisQ54517644
Effects of methyl methanesulfonate on mouse sperm chromatin structure and testicular cell kineticsQ70587445
Andrology: Cumulative conception rate following intrauterine artificial insemination with husband's spermatozoa: influence of husband's ageQ72017293
Oxidative stress in the male germ line and its role in the aetiology of male infertility and genetic diseaseQ73832606
Sperm chromatin structure assay parameters as predictors of failed pregnancy following assisted reproductive techniquesQ74089732
Linear increase of diploidy in human sperm with age: a four-colour FISH studyQ74237840
Sperm aneuploidy rates in younger and older menQ74398020
Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinicQ77377452
The applicability of the flow cytometric sperm chromatin structure assay in epidemiological studies. AsclepiosQ77525169
The spectrum of DNA damage in human sperm assessed by single cell gel electrophoresis (Comet assay) and its relationship to fertilization and embryo developmentQ77851909
Linear increase of structural and numerical chromosome 9 abnormalities in human sperm regarding ageQ79087822
Correlation between sperm motility and sperm chromatin structure assay parametersQ79358722
Meta-analysis of sperm DNA fragmentation using the sperm chromatin structure assayQ83893407
P433issue25
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
P304page(s)9601-9606
P577publication date2006-06-09
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleAdvancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm
P478volume103

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