Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

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Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1022384186
P356DOI10.1186/1750-1326-6-60
P932PMC publication ID3174124
P698PubMed publication ID21854604
P5875ResearchGate publication ID51583658

P2093author name stringChun-I Sze
Subbiah Pugazhenthi
Maorong Wang
Christopher B Eckman
Serena Pham
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Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinaseQ28283499
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Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133Q29617856
Mechanisms underlying inflammation in neurodegenerationQ29617977
Function and regulation of CREB family transcription factors in the nervous systemQ29619559
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signalsQ29620470
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathologyQ30633722
Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.Q31840691
CREB couples neurotrophin signals to survival messagesQ33857179
Oxidative stress in Alzheimer's diseaseQ33971332
Apoptosis in neurodegenerative disordersQ34186312
Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signalingQ34192226
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Evidence of increased oxidative damage in subjects with mild cognitive impairment.Q34410726
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Astrocyte apoptosis: implications for neuroprotectionQ35737824
Iron accumulation in Alzheimer disease is a source of redox-generated free radicalsQ36577461
Inflammation in Alzheimer disease: driving force, bystander or beneficial response?Q36589042
Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responsesQ36605276
Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memoryQ37089849
Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatmentQ37625928
CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models.Q37707617
CREB: a multifaceted regulator of neuronal plasticity and protectionQ37806285
A gene expression profile of Alzheimer's diseaseQ38293042
Recovery and expression of messenger RNA from postmortem human brain tissueQ40593387
CREB: a mediator of long-term memory from mollusks to mammalsQ40630853
Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cellsQ40658019
Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons.Q40668530
Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.Q40831748
Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein.Q40928862
Oxidative stress hypothesis in Alzheimer's diseaseQ41482152
Amyloid beta-protein toxicity and oxidative stress in Alzheimer's diseaseQ41642912
Effects of inorganic lead on the differentiation and growth of cultured hippocampal and neuroblastoma cells.Q41708882
Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells. Involvement of p38 mitogen-activated protein kinase-mediated pathway.Q42466887
Beta -amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromisedQ43559766
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's diseaseQ43727698
Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodentsQ43806238
Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons.Q44752355
Comparative analysis of cortical gene expression in mouse models of Alzheimer's diseaseQ46519969
Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenalQ46842782
beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.Q48009625
Stimulation of cAMP response element (CRE)-mediated transcription during contextual learningQ48240067
Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampusQ48983531
Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons.Q51996386
Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months.Q52012764
Elevated amyloid beta protein(1-40) level induces CREB phosphorylation at serine-133 via p44/42 MAP kinase (Erk1/2)-dependent pathway in rat pheochromocytoma PC12 cells.Q52043496
The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†Q58842885
Significant reductions in synapsin but not synaptophysin specific activity in the brains of some schizophrenicsQ72690265
P921main subjectAlzheimer's diseaseQ11081
P304page(s)60
P577publication date2011-08-19
P1433published inMolecular NeurodegenerationQ15817329
P1476titleDownregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons
P478volume6

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