| scholarly article | Q13442814 |
| review article | Q7318358 |
| P6179 | Dimensions Publication ID | 1019716419 |
| P356 | DOI | 10.1038/NCPENDMET0196 |
| P698 | PubMed publication ID | 16932309 |
| P50 | author | Christos Socrates Mantzoros | Q26702668 |
| P2093 | author name string | Aoife M Brennan | |
| P2860 | cites work | Positional cloning of the mouse obese gene and its human homologue | Q22251285 |
| A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction | Q24322907 | ||
| Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice | Q24563099 | ||
| Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice | Q24620943 | ||
| The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men | Q24676406 | ||
| Crystal structure of the obese protein leptin-E100 | Q27737094 | ||
| Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin | Q28115346 | ||
| Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass | Q28505908 | ||
| Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression | Q28594263 | ||
| Leptin and the regulation of body weight in mammals | Q29615976 | ||
| Serum immunoreactive-leptin concentrations in normal-weight and obese humans | Q29617230 | ||
| Role of leptin in the neuroendocrine response to fasting | Q29618866 | ||
| Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus | Q29619635 | ||
| The role of leptin in human obesity and disease: a review of current evidence | Q33601309 | ||
| Effects of recombinant leptin therapy in a child with congenital leptin deficiency. | Q33874084 | ||
| Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy | Q34129374 | ||
| Leptin regulates bone formation via the sympathetic nervous system | Q34157988 | ||
| Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight | Q34160218 | ||
| Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults | Q34311822 | ||
| Recombinant human leptin in women with hypothalamic amenorrhea. | Q34345206 | ||
| Obesity-associated hypertension: new insights into mechanisms. | Q34374149 | ||
| Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro | Q34377910 | ||
| Leptin alters the response of the growth hormone releasing factor- growth hormone--insulin-like growth factor-I axis to fasting | Q48363298 | ||
| Effects of intracerebroventricular infusion of leptin in obese Zucker rats. | Q48577529 | ||
| Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo | Q57533674 | ||
| Basal corticosterone levels of young og/ob mice | Q67556296 | ||
| Mechanism of insulin resistance in A-ZIP/F-1 fatless mice | Q73561042 | ||
| Effect of dietary restraint during and following pegylated recombinant leptin (PEG-OB) treatment of overweight men | Q79317975 | ||
| Long-term leptin-replacement therapy for lipoatrophic diabetes | Q80418874 | ||
| Abnormal splicing of the leptin receptor in diabetic mice | Q34379335 | ||
| Leptin in immunology | Q34400407 | ||
| Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. | Q34425222 | ||
| Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa | Q34430584 | ||
| Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress | Q34437169 | ||
| Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. | Q34785785 | ||
| Leptin resistance - or why leptin fails to work in obesity | Q35073227 | ||
| Life without white fat: a transgenic mouse | Q35210661 | ||
| Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy | Q35210714 | ||
| Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance | Q35630443 | ||
| Leptin-induced signal transduction pathways. | Q35676024 | ||
| Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity | Q35774658 | ||
| Lipodystrophies: rare disorders causing metabolic syndrome | Q35781469 | ||
| Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis | Q35893875 | ||
| Cardiovascular risk and body-fat abnormalities in HIV-infected adults | Q36000980 | ||
| Monogenic obesity in humans | Q36014729 | ||
| Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. | Q36246132 | ||
| Leptin is a potent stimulator of bone growth in ob/ob mice | Q38307707 | ||
| Rapid rewiring of arcuate nucleus feeding circuits by leptin. | Q38342803 | ||
| Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans | Q38358665 | ||
| Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice | Q38359964 | ||
| Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy | Q40331192 | ||
| Intracellular signal transduction pathways induced by leptin in C2C12 cells. | Q40404639 | ||
| Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess. | Q40459379 | ||
| Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes. | Q43618955 | ||
| Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia | Q43950679 | ||
| Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: Impact on differentiation markers, apoptosis, and osteoclastic signaling | Q43968126 | ||
| Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans | Q44043203 | ||
| Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy. | Q44055135 | ||
| Leptin Regulates Functional Capacities of Polymorphonuclear Neutrophils | Q44623929 | ||
| Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with r | Q45197374 | ||
| Diabetes, obesity, and the brain | Q45232063 | ||
| The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients | Q45250374 | ||
| Leptin-replacement therapy for lipodystrophy. | Q45714149 | ||
| Long-term efficacy of leptin replacement in patients with generalized lipodystrophy | Q46570536 | ||
| Effects of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation | Q46632231 | ||
| Overweight humans are resistant to the weight-reducing effects of melanocortin4-10. | Q46827200 | ||
| Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial | Q47254016 | ||
| Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice | Q47372073 | ||
| Expression of leptin receptor isoforms in rat brain microvessels | Q47777435 | ||
| Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy. | Q47876992 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | pathophysiology | Q1135939 |
| P304 | page(s) | 318-327 | |
| P577 | publication date | 2006-06-01 | |
| P1433 | published in | Nature Clinical Practice Endocrinology and Metabolism | Q15750240 |
| P1476 | title | Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications | |
| P478 | volume | 2 |
| Q40937669 | A Fomitopsis pinicola Jeseng Formulation Has an Antiobesity Effect and Protects against Hepatic Steatosis in Mice with High-Fat Diet-Induced Obesity |
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| Q50523060 | A combination of grape extract, green tea extract and L-carnitine improves high-fat diet-induced obesity, hyperlipidemia and non-alcoholic fatty liver disease in mice. |
| Q34983582 | A meta-analysis of reference values of leptin concentration in healthy postmenopausal women |
| Q36464186 | Adipocytokines in sleep apnea syndrome |
| Q57864838 | Adipose transcriptome analysis provides novel insights into molecular regulation of prolonged fasting in northern elephant seal pups |
| Q24656239 | Adverse metabolic and cardiovascular consequences of circadian misalignment |
| Q34237631 | Anorexia nervosa: a unified neurological perspective |
| Q90787695 | Anthropometric and glucometabolic changes in an aged mouse model of lipocalin-2 overexpression |
| Q41570942 | Anti-obesity and cardioprotective effects of cinnamic acid in high fat diet- induced obese rats. |
| Q33769574 | Association between inflammatory biomarkers and adiposity in obese patients with heart failure and metabolic syndrome |
| Q36645830 | B-cell-activating factor is a regulator of adipokines and a possible mediator between adipocytes and macrophages |
| Q47161157 | Benefits of Nut Consumption on Insulin Resistance and Cardiovascular Risk Factors: Multiple Potential Mechanisms of Actions |
| Q36906149 | Bone metabolism compensates for the delayed growth in small for gestational age neonates |
| Q48879223 | C-reactive protein as an available biomarker determining mental component of health-related quality of life among individuals with spinal cord injury. |
| Q37647283 | Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research |
| Q35885563 | Cardiomyocyte Antihypertrophic Effect of Adipose Tissue Conditioned Medium from Rats and Its Abrogation by Obesity is Mediated by the Leptin to Adiponectin Ratio |
| Q33432815 | Catch-up growth following fetal growth restriction promotes rapid restoration of fat mass but without metabolic consequences at one year of age. |
| Q38133690 | Changes of leptin concentration in plasma in patients with spinal cord injury: a meta-analysis |
| Q34452590 | Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain |
| Q37386817 | Cord blood leptin and adiponectin as predictors of adiposity in children at 3 years of age: a prospective cohort study |
| Q35001847 | Cross-sectional evidence of a signaling pathway from bone homeostasis to glucose metabolism |
| Q37885803 | Cryptogenic chronic hepatitis and its changing guise in adults |
| Q36050838 | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine |
| Q35477702 | Dietary fat quality impacts genome-wide DNA methylation patterns in a cross-sectional study of Greek preadolescents |
| Q58781397 | Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants |
| Q36859602 | Differential associations of leptin with adiposity across early childhood |
| Q91990565 | Effect of Kombucha on gut-microbiota in mouse having non-alcoholic fatty liver disease |
| Q41988736 | Effect of ascorbic acid and alpha-tocopherol supplementations on serum leptin, tumor necrosis factor alpha, and serum amyloid A levels in individuals with type 2 diabetes mellitus |
| Q37113912 | Effects of angiotensin II type 1 receptor blocker and adiponectin on adipocyte dysfunction in stroke-prone spontaneously hypertensive rats |
| Q37500257 | Effects of varying degrees of intermittent hypoxia on proinflammatory cytokines and adipokines in rats and 3T3-L1 adipocytes |
| Q47997334 | Elevated triglycerides are associated with decreased executive function among adolescents with bipolar disorder |
| Q49437735 | Enteric parasites can disturb leptin and adiponectin levels in children. |
| Q33623924 | Estrogen: a master regulator of bioenergetic systems in the brain and body |
| Q38865992 | Evaluation of leptin, interleukin-1 beta and tumor necrosis factor alpha in serum of malaria patients as prognostic markers of treatment outcome |
| Q26822992 | Exercise induced adipokine changes and the metabolic syndrome |
| Q93386979 | Exercise testing and adipokine levels for the evaluation of overweight and obesity in children |
| Q38433930 | Exploring genetic susceptibility to obesity through genome functional pathway analysis |
| Q57459389 | Fasting and cancer: molecular mechanisms and clinical application |
| Q26865887 | Fat and Bone: An Odd Couple |
| Q34029523 | Gene set enrichment analysis for multiple continuous phenotypes |
| Q34310244 | Green tea polyphenols reduce body weight in rats by modulating obesity-related genes |
| Q90591983 | High Maternal and Low Cord Blood Leptin Are Associated with BMI-SDS Gain in the First Year of Life |
| Q92509126 | Hormones in Breast Milk and Effect on Infants' Growth: A Systematic Review |
| Q37052291 | Human milk glycoproteins protect infants against human pathogens |
| Q26992274 | Hypercholesterolemia induces adipose dysfunction in conditions of obesity and nonobesity |
| Q54592498 | Immunohistochemical and immunological detection of ghrelin and leptin in rainbow trout Oncorhynchus mykiss and murray cod Maccullochella peelii peelii as affected by different dietary fatty acids |
| Q38855731 | Impact of anthropometric measures and serum leptin on severity of gastroesophageal reflux disease |
| Q38832643 | Impact of statin therapy on plasma leptin concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials |
| Q36363679 | In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist. |
| Q51385645 | Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy. |
| Q24635451 | Inflammation in depression: is adiposity a cause? |
| Q38352166 | Influence of maternal overnutrition and gestational diabetes on the programming of metabolic health outcomes in the offspring: experimental evidence |
| Q34139677 | Insights into the use of biomarkers in calcific aortic valve disease |
| Q92257701 | Interaction of Osteoarthritis and BMI on Leptin Promoter Methylation in Taiwanese Adults |
| Q47216965 | Iridoids and Other Monoterpenes in the Alzheimer's Brain: Recent Development and Future Prospects |
| Q37980322 | Leptin and the hypothalamo-pituitary-adrenal stress axis |
| Q33883294 | Leptin deficiency: clinical implications and opportunities for therapeutic interventions |
| Q35321788 | Leptin in human physiology and pathophysiology. |
| Q34047024 | Leptin in human physiology and therapeutics |
| Q37155251 | Leptin in humans: lessons from translational research |
| Q36049195 | Leptin in relation to the lipodystrophy-associated metabolic syndrome |
| Q42365079 | Leptin signaling and cancer chemoresistance: Perspectives |
| Q26859118 | Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals |
| Q34015256 | Leptin: a novel therapeutic strategy for Alzheimer's disease |
| Q34299762 | Locus of control and obesity |
| Q34043959 | Maternal diet and cord blood leptin and adiponectin concentrations at birth |
| Q34592847 | Mice without macroH2A histone variants |
| Q64243637 | Molecular dynamic (MD) studies on Gln233Arg (rs1137101) polymorphism of leptin receptor gene and associated variations in the anthropometric and metabolic profiles of Saudi women |
| Q26862798 | Mood disorders: A potential link between ghrelin and leptin on human body? |
| Q89108940 | Mouse models of hepatocellular carcinoma: an overview and highlights for immunotherapy research |
| Q90455581 | Obesity and childhood asthma in male schoolchildren in Saudi Arabia: Is there a role for leptin, interleukin-4, interleukin-5, and interleukin-21? |
| Q33883337 | Optimizing bone health in anorexia nervosa and hypothalamic amenorrhea: new trials and tribulations. |
| Q35129333 | Ozone induces glucose intolerance and systemic metabolic effects in young and aged Brown Norway rats |
| Q34892998 | Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study |
| Q33793062 | Physical fitness and plasma leptin in women with recent gestational diabetes |
| Q36830035 | Potential mechanisms of exercise in gestational diabetes |
| Q28831200 | Recombinant production of medium- to large-sized peptides in Escherichia coli using a cleavable self-aggregating tag |
| Q35877220 | Red pitaya betacyanins protects from diet-induced obesity, liver steatosis and insulin resistance in association with modulation of gut microbiota in mice |
| Q45902685 | Relationships between serum adipocyte hormones (adiponectin, leptin, resistin), bone mineral density and bone metabolic markers in osteoporosis patients. |
| Q38741056 | Renal Nerves and Long-Term Control of Arterial Pressure |
| Q34697373 | Role of Notch and its oncogenic signaling crosstalk in breast cancer |
| Q39760512 | Selective inhibition of hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction. |
| Q35228307 | Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study |
| Q28543388 | Short and long-term impact of lipectomy on expression profile of hepatic anabolic genes in rats: a high fat and high cholesterol diet-induced obese model |
| Q46921352 | Short-term treatment with ezetimibe, simvastatin or their combination does not alter circulating adiponectin, resistin or leptin levels in healthy men. |
| Q37419287 | Signaling proteins are represented in tissue fluid/lymph from soft tissues of normal human legs at concentrations different from serum. |
| Q36722069 | Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice |
| Q47671257 | The 'boon and bane' of antipsychotic-induced metabolic syndrome |
| Q55516074 | The adiponectin promoter activator NP-1 induces high levels of circulating TNFα and weight loss in obese (fa/fa) Zucker rats. |
| Q37632445 | The association between depression and leptin is mediated by adiposity |
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