Successful in vitro expansion and differentiation of cord blood derived CD34+ cells into early endothelial progenitor cells reveals highly differential gene expression

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Successful in vitro expansion and differentiation of cord blood derived CD34+ cells into early endothelial progenitor cells reveals highly differential gene expression is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...623210A
P356DOI10.1371/JOURNAL.PONE.0023210
P932PMC publication ID3155543
P698PubMed publication ID21858032
P5875ResearchGate publication ID51586840

P50authorChristoph BodeQ60457714
Jeremy B M JowettQ114358645
Karlheinz PeterQ47504540
Martha LappasQ59694807
P2093author name stringIzhak Haviv
Ingo Ahrens
Helena Domeij
Denijal Topcic
Alexander Agrotis
Ephraem Leitner
Ruusu-Maaria Merivirta
P2860cites workMolecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities.Q21202035
Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epitheliumQ24537181
High-reproducible flow cytometric endothelial progenitor cell determination in human peripheral blood as CD34+/CD144+/CD3− lymphocyte sub-populationQ63915190
Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factorsQ73075799
Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: a pilot randomized controlled trialQ80120591
Growth differentiation factor-15 and cardiovascular dysfunction and disease: malefactor or innocent bystander?Q83366281
Is endothelium the origin of endothelial progenitor cells?Q37746575
Gene expression profiles of endothelial progenitor cells by oligonucleotide microarray analysisQ38306031
Efficient nonadhesive ex vivo expansion of early endothelial progenitor cells derived from CD34 + human cord blood fraction for effective therapeutic vascularizationQ39654125
Evidence for a differential functional regulation of the two beta(3)-integrins alpha(V)beta(3) and alpha(IIb)beta(3).Q40325682
Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein.Q42086638
Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled studyQ46693648
Accelerated lipid-induced atherogenesis in galectin-3-deficient mice: role of lipoxidation via receptor-mediated mechanisms.Q48024001
CD61 enriches long-term repopulating hematopoietic stem cells.Q50870735
NF kappaB activation in embryonic endothelial progenitor cells enhances neovascularization via PSGL-1 mediated recruitment: novel role for LL37.Q54450087
GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in miceQ58807888
Cluster analysis and display of genome-wide expression patternsQ24644463
Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemiaQ24805262
Exploration, normalization, and summaries of high density oligonucleotide array probe level dataQ27861098
GDF15, a cardioprotective TGF-beta superfamily proteinQ28297925
Isolation of putative progenitor endothelial cells for angiogenesisQ28302884
Endothelial progenitor cells: identity defined?Q28303395
Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardiumQ28569342
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesQ29547229
Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI TrialQ33151955
The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injuryQ33231048
Extending pathways based on gene lists using InterPro domain signaturesQ33313427
Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell culturesQ33385959
Human cord blood-derived AC133+ progenitor cells preserve endothelial progenitor characteristics after long term in vitro expansionQ33531800
Generation of Novel Bone Forming Cells (Monoosteophils) from the Cathelicidin-Derived Peptide LL-37 Treated MonocytesQ33749859
Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursorsQ33887795
An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.Q34534186
Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin.Q34653027
The endothelial cell tube formation assay on basement membrane turns 20: state of the science and the art.Q34978149
Endothelial progenitor cells: mobilization, differentiation, and homingQ35114634
Galectin-3 induces endothelial cell morphogenesis and angiogenesisQ35809815
Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cellsQ36402579
Molecular profiling of hematopoietic stem cellsQ36897866
Growth-differentiation factor-15 for early risk stratification in patients with acute chest painQ36916244
Therapeutic myocardial angiogenesisQ36976439
Endothelial progenitor cells in neovascularization of infarcted myocardiumQ37066764
The human cathelicidin LL-37 modulates the activities of the P2X7 receptor in a structure-dependent manner.Q37142680
Assessing identity, phenotype, and fate of endothelial progenitor cellsQ37231424
Atheroprotective properties of pigment epithelium-derived factor (PEDF) in cardiometabolic disordersQ37411485
From bone marrow to the arterial wall: the ongoing tale of endothelial progenitor cells.Q37418551
Progenitor cell trafficking in the vascular wallQ37561409
Defining human endothelial progenitor cellsQ37561425
Endothelial-regenerating cells: an expanding universeQ37677405
Clinical potential of adult vascular progenitor cells.Q37746559
Regulation of bone marrow-derived vascular progenitor cell mobilization and maintenanceQ37746565
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)e23210
P577publication date2011-08-12
P1433published inPLOS OneQ564954
P1476titleSuccessful in vitro expansion and differentiation of cord blood derived CD34+ cells into early endothelial progenitor cells reveals highly differential gene expression
P478volume6

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cites work (P2860)
Q39147616A Preliminary Study of the Therapeutic Role of Human Early Fetal Aorta-derived Endothelial Progenitor Cells in Inhibiting Carotid Artery Neointimal Hyperplasia
Q41521175Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
Q45193574Adipose-derived stem cells induce vascular tube formation of outgrowth endothelial cells in a fibrin matrix.
Q37630979An effective ex-vivo approach for inducing endothelial progenitor cells from umbilical cord blood CD34+ cells
Q38072068Chemical warfare agent and biological toxin-induced pulmonary toxicity: could stem cells provide potential therapies?
Q28293322Circulating and tissue resident endothelial progenitor cells
Q36703043Concise Review: Endothelial Progenitor Cells in Regenerative Medicine: Applications and Challenges
Q38066215Cord blood endothelial progenitor cells as therapeutic and imaging probes
Q36913515Endothelial aging associated with oxidative stress can be modulated by a healthy mediterranean diet
Q39401838Endothelial colony-forming cells and pro-angiogenic cells: clarifying definitions and their potential role in mitigating acute kidney injury.
Q36944663Extrarenal Progenitor Cells Do Not Contribute to Renal Endothelial Repair.
Q38269050Galectins in tumor angiogenesis
Q36777717Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease
Q39140242Increased plasma VEGF levels following ischemic preconditioning are associated with downregulation of miRNA-762 and miR-3072-5p
Q42659186Isolation and characterization of human umbilical cord-derived endothelial colony-forming cells
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Q27027852Regenerative therapies for diabetic microangiopathy
Q21284530Regulation of EPCs: The Gateway to Blood Vessel Formation
Q64093207Single-Cell RNA Sequencing of Human Embryonic Stem Cell Differentiation Delineates Adverse Effects of Nicotine on Embryonic Development
Q91144960Validation of reference genes for real-time PCR of cord blood mononuclear cells, differentiating endothelial progenitor cells, and mature endothelial cells

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