Probucol plus cilostazol attenuate hypercholesterolemia‑induced exacerbation in ischemic brain injury via anti-inflammatory effects

scientific article

Probucol plus cilostazol attenuate hypercholesterolemia‑induced exacerbation in ischemic brain injury via anti-inflammatory effects is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/IJMM.2014.1848
P932PMC publication ID4121353
P698PubMed publication ID25017431
P5875ResearchGate publication ID263896464

P2093author name stringSun Sik Bae
Ji Hyun Kim
Ki Whan Hong
Byung Tae Choi
Hwa Kyoung Shin
Yong-Il Shin
P2860cites workAspirin and extended-release dipyridamole versus clopidogrel for recurrent strokeQ24646522
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Ex vivo lipopolysaccharide-induced interleukin-1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with antioxidant propertiesQ28334440
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Hypercholesterolemia, lipid-lowering agents, and the risk for brain infarctionQ34365500
The vascular effects of cilostazolQ36405138
MCP-1 protects mice in lethal endotoxemiaQ37368530
Cholesterol oxidation products and disease: an emerging topic of interest in medicinal chemistry.Q37387429
Synergistic efficacy of concurrent treatment with cilostazol and probucol on the suppression of reactive oxygen species and inflammatory markers in cultured human coronary artery endothelial cellsQ37459012
Where are we with probucol: a new life for an old drug?Q37490346
Diet-induced obesity causes cerebral vessel remodeling and increases the damage caused by ischemic strokeQ37648333
Oxysterol derivatives of cholesterol in neurodegenerative disordersQ37856338
Stroke and the immune system: from pathophysiology to new therapeutic strategiesQ37867782
Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of genderQ39128180
Obesity increases blood pressure, cerebral vascular remodeling, and severity of stroke in the Zucker rat.Q39647425
Microglial activation in the hippocampus of hypercholesterolemic rabbits occurs independent of increased amyloid productionQ40016454
Risk factor profile and management of cerebrovascular patients in the REACH RegistryQ40114179
Cilostazol reduces atherosclerosis by inhibition of superoxide and tumor necrosis factor-alpha formation in low-density lipoprotein receptor-null mice fed high cholesterol.Q40453919
Probucol as an antioxidant and antiatherogenic drugQ40887005
Hypertension and stroke.Q41446999
High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.Q41881815
Influence of hypercholesterolemia and hypertension on the integrity of the blood-brain barrier in ratsQ43239573
Effects of cholesterol and inflammation-sensitive plasma proteins on incidence of myocardial infarction and stroke in men.Q44015016
Combinatorial effect of probucol and cilostazol in focal ischemic mice with hypercholesterolemiaQ44808585
The epidemiology of overweight and obesity: public health crisis or moral panic?Q44947045
LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.Q46019644
Antiatherogenic effects of cilostazol and probucol alone, and in combination in low density lipoprotein receptor-deficient mice fed with a high fat dietQ46650594
High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein E knockout and wild type miceQ46730918
Neuroprotection by cilostazol, a phosphodiesterase type 3 inhibitor, against apoptotic white matter changes in rat after chronic cerebral hypoperfusionQ46974633
Beneficial synergistic effects of concurrent treatment with cilostazol and probucol against focal cerebral ischemic injury in ratsQ48158533
Overexpression of monocyte chemoattractant protein 1 in the brain exacerbates ischemic brain injury and is associated with recruitment of inflammatory cellsQ48285984
Effect of brain edema on infarct volume in a focal cerebral ischemia model in ratsQ48365404
Brain cytokine synthesis induced by an intraparenchymal injection of LPS is reduced in MCP-1-deficient mice prior to leucocyte recruitmentQ48457563
Behavioral tests after intracerebral hemorrhage in the rat.Q48475050
Monocyte chemoattractant protein-1 deficiency is protective in a murine stroke modelQ48663782
Trends in stroke hospitalizations and associated risk factors among children and young adults, 1995-2008.Q48913040
Salvianolic acid B attenuates brain damage and inflammation after traumatic brain injury in mice.Q51028188
Type 2 Diabetes Mellitus and Insulin Resistance: Stroke Prevention and Management.Q51527048
Probucol attenuates inflammation and increases stability of vulnerable atherosclerotic plaques in rabbits.Q52615374
Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. II. Cellular composition and proliferation.Q54161571
Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide SynthaseQ71647466
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial treeQ72689998
Differential induction of chemokines in human microglia by type I and II interferonsQ73372530
Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient miceQ79758392
P433issue3
P921main subjecthypercholesterolemiaQ762713
P304page(s)687-694
P577publication date2014-07-10
P1433published inInternational Journal of Molecular MedicineQ6051492
P1476titleProbucol plus cilostazol attenuate hypercholesterolemia‑induced exacerbation in ischemic brain injury via anti-inflammatory effects
P478volume34

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cites work (P2860)
Q37151611Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice
Q36530909Synergistic Effects of Cilostazol and Probucol on ER Stress-Induced Hepatic Steatosis via Heme Oxygenase-1-Dependent Activation of Mitochondrial Biogenesis

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