Inhibition of dengue virus by targeting viral NS4B protein

scientific article

Inhibition of dengue virus by targeting viral NS4B protein is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.05468-11
P932PMC publication ID3194949
P698PubMed publication ID21865382

P50authorXuping XieQ54118103
Laura D KramerQ56450083
Pei-Yong ShiQ59435668
P2093author name stringMin Qing
Zhiming Yuan
Hao Ying Xu
Qing-Yin Wang
P2860cites workA small-molecule dengue virus entry inhibitorQ22309806
Inhibition of interferon signaling by dengue virusQ24630622
The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acidsQ27469354
Development of a cell-based high-throughput specificity screen using a hepatitis C virus-bovine viral diarrhea virus dual replicon assay.Q27469439
Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function.Q27469704
Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of FlavivirusesQ27469841
Structure of the Dengue Virus Helicase/Nucleoside Triphosphatase Catalytic Domain at a Resolution of 2.4 AQ27470453
An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterizationQ27472613
Mutations in the Yellow Fever Virus Nonstructural Protein NS2A Selectively Block Production of Infectious ParticlesQ27472873
Infectious cDNA clone of the epidemic west nile virus from New York CityQ27472878
Triaryl pyrazoline compound inhibits flavivirus RNA replicationQ27473130
West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5Q27477465
Molecular and Functional Analyses of Kunjin Virus Infectious cDNA Clones Demonstrate the Essential Roles for NS2A in Virus Assembly and for a Nonconservative Residue in NS3 in RNA ReplicationQ27477562
Characterization of Hepatitis C Virus Subgenomic Replicon Resistance to Cyclosporine In VitroQ27480361
trans-Complementation of yellow fever virus NS1 reveals a role in early RNA replicationQ27485867
Deletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activityQ27486196
Processing of the yellow fever virus nonstructural polyprotein: a catalytically active NS3 proteinase domain and NS2B are required for cleavages at dibasic sitesQ27486606
Exclusion of West Nile Virus Superinfection through RNA ReplicationQ27490309
An adenosine nucleoside inhibitor of dengue virusQ27490481
Identification of Hepatitis C Virus NS5A InhibitorsQ27490539
Small Molecule Inhibitors That Selectively Block Dengue Virus MethyltransferaseQ27666321
Recombinant dengue type 1 virus NS5 protein expressed in Escherichia coli exhibits RNA-dependent RNA polymerase activityQ28276481
Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteinsQ29620712
West Nile virus inhibits the signal transduction pathway of alpha interferonQ33718537
A fluorescence-based alkaline phosphatase-coupled polymerase assay for identification of inhibitors of dengue virus RNA-dependent RNA polymeraseQ33789790
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effectQ34022149
Strategies for development of Dengue virus inhibitorsQ34091777
Functional analysis of two cavities in flavivirus NS5 polymeraseQ34800273
A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.Q38912795
Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2'-O methyltransferase activity in dengue virusQ38947082
Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testingQ39301197
Inhibition of dengue virus polymerase by blocking of the RNA tunnelQ39306357
A high-throughput assay using dengue-1 virus-like particles for drug discoveryQ39373894
Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA.Q39541510
Development and characterization of a stable luciferase dengue virus for high-throughput screeningQ39541700
N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymeraseQ39616455
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.Q39616465
Peptide inhibitors of Dengue virus NS3 protease. Part 1: WarheadQ39616471
The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated mannerQ40174839
Studies on avian infectious bronchitis virus (IBV). III. Interferon induction by and sensitivity to interferon of IBV.Q40272135
Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B.Q40325204
A trade-off in replication in mosquito versus mammalian systems conferred by a point mutation in the NS4B protein of dengue virus type 4.Q40553373
De novo synthesis of RNA by the dengue virus RNA-dependent RNA polymerase exhibits temperature dependence at the initiation but not elongation phaseQ40596948
The NS 3 nonstructural protein of flaviviruses contains an RNA triphosphatase activityQ41517814
The carboxy-terminal part of the NS 3 protein of the West Nile Flavivirus can be isolated as a soluble protein after proteolytic cleavage and represents an RNA-stimulated NTPaseQ42985863
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectDengue virusQ476209
Chikungunya virusQ15794049
P304page(s)11183-11195
P577publication date2011-08-24
P1433published inJournal of VirologyQ1251128
P1476titleInhibition of dengue virus by targeting viral NS4B protein
P478volume85

Reverse relations

cites work (P2860)
Q35758578A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication
Q37415438A Novel Benzodiazepine Compound Inhibits Yellow Fever Virus Infection by Specifically Targeting NS4B Protein.
Q35022038A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease
Q36505563A novel inhibitor of dengue virus replication that targets the capsid protein
Q38866173An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection
Q35647755Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase
Q55277816Biochemistry and Molecular Biology of Flaviviruses.
Q40279649Bioinformatics prediction of siRNAs as potential antiviral agents against dengue viruses
Q29994527Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond
Q35487910Characterization of dengue virus NS4A and NS4B protein interaction
Q115215852Compartmentalized replication organelle of flavivirus at the ER and the factors involved
Q86939020Computer-Assisted and Data Driven Approaches for Surveillance, Drug Discovery, and Vaccine Design for the Zika Virus
Q39249833Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection
Q115234716Dengue Virus NS4b N-Terminus Disordered Region Interacts with NS3 Helicase C-Terminal Subdomain to Enhance Helicase Activity
Q90825369Dengue drug discovery: Progress, challenges and outlook
Q28542607Dengue therapeutics, chemoprophylaxis, and allied tools: state of the art and future directions
Q54232092Dengue virus NS2 and NS4: Minor proteins, mammoth roles.
Q57283594Dengue virus and the host innate immune response
Q28085044Dengue: an update on treatment options
Q35760466Determinants of Dengue Virus NS4A Protein Oligomerization
Q37643762Dimerization of flavivirus NS4B protein
Q35643850Discovery of Dengue Virus NS4B Inhibitors
Q36730021Escape Mutations in NS4B Render Dengue Virus Insensitive to the Antiviral Activity of the Paracetamol Metabolite AM404
Q101116526Evolution of resistance to fluoroquinolones by dengue virus serotype 4 provides insight into mechanism of action and consequences for viral fitness
Q36586306Experimental therapies for yellow fever
Q26314693Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention
Q115215932Flavivirus NS4B protein: Structure, function, and antiviral discovery
Q37123525Flaviviruses are sensitive to inhibition of thymidine synthesis pathways
Q39255013Generation and characterization of mouse monoclonal antibodies against NS4B protein of dengue virus
Q28486302High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses
Q89334699High-throughput screening (HTS) for the identification of novel antiviral scaffolds
Q35742387Identification of dengue viral RNA-dependent RNA polymerase inhibitor using computational fragment-based approaches and molecular dynamics study
Q59000638Immunogenicity of NS4b Dengue 3 Virus Mimotope Presented to the Immune System as Multiple Antigen Peptide System
Q38096721Intervention strategies for emerging viruses: use of antivirals
Q34246661Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug
Q39633694Lead optimization of spiropyrazolopyridones: a new and potent class of dengue virus inhibitors
Q37057168Luminescent multiplex viability assay for Trypanosoma brucei gambiense
Q35488254Mapping the Interactions between the NS4B and NS3 proteins of dengue virus
Q27676369Membrane Topology and Function of Dengue Virus NS2A Protein
Q35745411Mutation of Putative N-Glycosylation Sites on Dengue Virus NS4B Decreases RNA Replication
Q28548514Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase
Q34206832Novel approaches to flavivirus drug discovery
Q114704016Novel insights into the function of an N-terminal region of DENV2 NS4B for the optimal helicase activity of NS3
Q114704018On track to tackle dengue: History and future of NS4B ligands
Q38953548Overlapping and distinct molecular determinants dictating the antiviral activities of TRIM56 against flaviviruses and coronavirus
Q39017020Peptide inhibitors against dengue virus infection.
Q35747460Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells
Q24700044Predicting Zika virus structural biology: Challenges and opportunities for intervention
Q37566687Replication cycle and molecular biology of the West Nile virus
Q58099567Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection
Q26860307Role of microparticles in dengue virus infection and its impact on medical intervention strategies
Q38156719Screening of FDA-Approved Drugs for Inhibitors against Japanese Encephalitis Virus Infection
Q38045106Structural biology of dengue virus enzymes: towards rational design of therapeutics
Q90737186Structure-Based Design of Antivirals against Envelope Glycoprotein of Dengue Virus
Q38916167Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors
Q56353961The A-Z of Zika drug discovery
Q115234654The Biogenesis of Dengue Virus Replication Organelles Requires the ATPase Activity of Valosin-Containing Protein
Q54557957The Dengue Virus Replication Complex: From RNA Replication to Protein-Protein Interactions to Evasion of Innate Immunity.
Q34923354The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication
Q28655818The citrus flavanone naringenin impairs dengue virus replication in human cells
Q40250047The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase.
Q34991051Two distinct sets of NS2A molecules are responsible for dengue virus RNA synthesis and virion assembly
Q37666750West Nile virus drug discovery
Q27928069Zika Virus Replicons for Drug Discovery

Search more.