Monoclonal antibody to Shiga toxin 2 which blocks receptor binding and neutralizes cytotoxicity

scientific article

Monoclonal antibody to Shiga toxin 2 which blocks receptor binding and neutralizes cytotoxicity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.67.11.5717-5722.1999
P932PMC publication ID96946
P698PubMed publication ID10531220

P2093author name stringJ Fujimoto
S Yamasaki
T Takeda
N Kiyokawa
H Nakao
P2860cites workIsolation and characterization of monoclonal antibodies to Shiga-like toxin II of enterohemorrhagic Escherichia coli and use of the monoclonal antibodies in a colony enzyme-linked immunosorbent assayQ37156797
Solution structure of the complex between the B-subunit homopentamer of verotoxin VT-1 from Escherichia coli and the trisaccharide moiety of globotriaosylceramide.Q38334764
Synthetic peptides of Shiga toxin B subunit induce antibodies which neutralize its biological activityQ40158183
Antibodies to shiga holotoxin and to two synthetic peptides of the B subunit in sera of patients with Shigella dysenteriae 1 dysenteryQ40186741
An evaluation of three in vitro cytotoxicity assaysQ42811543
The primary structure of the operons coding for Shigella dysenteriae toxin and temperature phage H30 shiga-like toxinQ48318734
Typing of verotoxins by DNA colony hybridization with poly- and oligonucleotide probes, a bead-enzyme-linked immunosorbent assay, and polymerase chain reaction.Q54596095
Construction of mutant genes for a non-toxic verotoxin 2 variant (VT2vp1) of Escherichia coli and characterization of purified mutant toxins.Q54645159
Non-radioactively labelled polynucleotide and oligonucleotide DNA probes, for selectively detecting Escherichia coli strains producing Vero cytotoxins VT1, VT2 and VT2 variant.Q54698259
Purification and some properties of a Vero toxin from Escherichia coli O157:H7 that is immunologically unrelated to Shiga toxin.Q54763750
Purification and some properties of Shiga-like toxin from Escherichia coli O157:H7 that is immunologically identical to Shiga toxin.Q54765418
Production and characterisation of monoclonal antibodies to Verotoxins 1 and 2 from Escherichia coli of serotype O 157:H7Q69115052
Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coliQ27644365
Crystal structure of the holotoxino from Shigella dysenteriae at 2.5 Å resolutionQ27729840
Structure of the shiga-like toxin I B-pentamer complexed with an analogue of its receptor Gb3Q27748877
Hemolytic-uremic syndrome and Vero cytotoxin-producing Escherichia coli infection in Italy. The HUS Italian Study GroupQ33367628
The Epidemiology of Infections Caused by Escherichia coli O157: H7, Other Enterohemorrhagic E. coli, and the Associated Hemolytic Uremic SyndromeQ33375970
Toxin genotypes and plasmid profiles as determinants of systemic sequelae in Escherichia coli O157:H7 infectionsQ33429817
Humoral immune responses to Shiga-like toxins and Escherichia coli O157 lipopolysaccharide in hemolytic-uremic syndrome patients and healthy subjectsQ33491823
Enzyme-linked immunosorbent assay for detection of immunoglobulin G antibodies to Escherichia coli Vero cytotoxin 1Q33492004
The role of Escherichia coli O 157 infections in the classical (enteropathic) haemolytic uraemic syndrome: results of a Central European, multicentre studyQ33494653
The detection of Shiga toxins in the kidney of a patient with hemolytic uremic syndromeQ33504952
Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humansQ33505189
Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins.Q34049372
Cloning and sequencing of a Shiga-like toxin type II variant from Escherichia coli strain responsible for edema disease of swineQ36215407
Serological responses to the B subunit of Shiga-like toxin 1 and its peptide fragments indicate that the B subunit is a vaccine candidate to counter action of the toxinQ36973479
Affinity purification and characterization of Shiga-like toxin II and production of toxin-specific monoclonal antibodiesQ36997934
Characterization of monoclonal antibodies against Shiga-like toxin from Escherichia coliQ37031424
Isolation and characterization of monoclonal antibodies to Shiga toxinQ37110126
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
cytotoxicityQ246181
monoclonal antibodyQ422248
P304page(s)5717-5722
P577publication date1999-11-01
P1433published inInfection and ImmunityQ6029193
P1476titleMonoclonal antibody to Shiga toxin 2 which blocks receptor binding and neutralizes cytotoxicity
P478volume67

Reverse relations

cites work (P2860)
Q35091607Antibody recognition of Shiga toxins (Stxs): computational identification of the epitopes of Stx2 subunit A to the antibodies 11E10 and S2C4
Q35581606Development and characterization of recombinant antibody fragments that recognize and neutralize in vitro Stx2 toxin from Shiga toxin-producing Escherichia coli.
Q37672981Efficacy of Urtoxazumab (TMA-15 Humanized Monoclonal Antibody Specific for Shiga Toxin 2) Against Post-Diarrheal Neurological Sequelae Caused by Escherichia coli O157:H7 Infection in the Neonatal Gnotobiotic Piglet Model
Q33340641Human Stx2-specific monoclonal antibodies prevent systemic complications of Escherichia coli O157:H7 infection
Q38843829Impact of the nature and size of the polymeric backbone on the ability of heterobifunctional ligands to mediate shiga toxin and serum amyloid p component ternary complex formation
Q42251450In silico analysis of Shiga toxins (Stxs) to identify new potential vaccine targets for Shiga toxin-producing Escherichia coli.
Q36329665Interaction between Shiga toxin and monoclonal antibodies: binding characteristics and in vitro neutralizing abilities.
Q36099489Monoclonal antibodies and toxins--a perspective on function and isotype
Q39625812Polyclonal antibodies to glutathione S-transferase--verotoxin subunit a fusion proteins neutralize verotoxins
Q33337841Prospects for the prevention of haemolytic-uraemic syndrome
Q35220377The 13C4 monoclonal antibody that neutralizes Shiga toxin Type 1 (Stx1) recognizes three regions on the Stx1 B subunit and prevents Stx1 from binding to its eukaryotic receptor globotriaosylceramide
Q27684790The Molecular Mechanism of Shiga Toxin Stx2e Neutralization by a Single-domain Antibody Targeting the Cell Receptor-binding Domain
Q54337514The design of new adjuvants for mucosal immunity to Neisseria meningitidis B in nasally primed neonatal mice for adult immune response.

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