Very low tidal volume ventilation with associated hypercapnia--effects on lung injury in a model for acute respiratory distress syndrome

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Very low tidal volume ventilation with associated hypercapnia--effects on lung injury in a model for acute respiratory distress syndrome is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...623816F
P356DOI10.1371/JOURNAL.PONE.0023816
P932PMC publication ID3158784
P698PubMed publication ID21886825
P5875ResearchGate publication ID51614485

P2093author name stringHans Fuchs
Michael Ebsen
Helmut D Hummler
Marc R Mendler
Dominik Scharnbeck
P2860cites workVentilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome NetworkQ27861021
Permissive range of hypercapnia for improved peripheral microcirculation and cardiac output in rabbitsQ33298874
Pumpless extracorporeal interventional lung assist in patients with acute respiratory distress syndrome: a prospective pilot studyQ37206705
Management of acute lung injury and acute respiratory distress syndrome in childrenQ37521481
Hypercapnic acidosis impairs plasma membrane wound resealing in ventilator-injured lungsQ42085814
Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal ratsQ43277466
Effects of hypercapnia with and without acidosis on hypoxic pulmonary vasoconstriction.Q43283583
Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injuryQ43792215
Arteriovenous extracorporeal lung assist as integral part of a multimodal treatment concept: a retrospective analysis of 22 patients with ARDS refractory to standard careQ44280375
Hypercapnic acidosis attenuates endotoxin-induced nuclear factor-[kappa]B activation.Q44324568
Hypercapnic acidosis attenuates endotoxin-induced acute lung injuryQ44575154
Hypercapnia via reduced rate and tidal volume contributes to lipopolysaccharide-induced lung injuryQ45101481
Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis.Q45966730
Acute hypercapnia improves indices of tissue oxygenation more than dobutamine in septic shockQ46942175
Acute ventilator-induced vascular permeability and cytokine responses in isolated and in situ mouse lungsQ47899204
Combining "open-lung" ventilation and arteriovenous extracorporeal lung assist: influence of different tidal volumes on gas exchange in experimental lung failure.Q48416235
Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappaB dependent mechanismQ48418472
Pumpless extracorporeal removal of carbon dioxide combined with ventilation using low tidal volume and high positive end-expiratory pressure in a patient with severe acute respiratory distress syndromeQ48453381
Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanismQ48468347
An unexpected ending: brain death following acute severe asthma.Q48922255
Are We Really Reducing Tidal Volume—And Should We?Q51674426
Meta-analysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes.Q51699164
Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury.Q51708605
Mechanical ventilation with permissive hypercapnia increases intrapulmonary shunt in septic and nonseptic patients with acute respiratory distress syndrome.Q51724458
Permissive hypercapnia impairs pulmonary gas exchange in the acute respiratory distress syndrome.Q52076323
Spontaneous breathing during partial liquid ventilation in animals with meconium aspiration.Q54015464
Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-kappaB and is blocked by steroids.Q54016111
Increased microvascular permeability in dog lungs due to high peak airway pressures.Q54464090
Tidal ventilation at low airway pressures can augment lung injury.Q55065976
Effects of inspired carbon dioxide on ventilation-perfusion matching in normoxia, hypoxia, and hyperoxiaQ71996725
Clinical risks for development of the acute respiratory distress syndromeQ72501931
Temporal hemodynamic effects of permissive hypercapnia associated with ideal PEEP in ARDSQ73885867
Protective effects of hypercapnic acidosis on ventilator-induced lung injuryQ74493910
Pumpless extracorporeal lung assist for protective mechanical ventilation in experimental lung injuryQ81456979
Does hypercapnia ameliorate hyperoxia-induced lung injury in neonatal rats?Q82333765
Tidal volume lower than 6 ml/kg enhances lung protection: role of extracorporeal carbon dioxide removalQ84536522
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectacute respiratory distress syndromeQ344873
hypercapniaQ615759
P304page(s)e23816
P577publication date2011-08-19
P1433published inPLOS OneQ564954
P1476titleVery low tidal volume ventilation with associated hypercapnia--effects on lung injury in a model for acute respiratory distress syndrome
P478volume6