Type-1 polarized dendritic cells primed for high IL-12 production show enhanced activity as cancer vaccines

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Type-1 polarized dendritic cells primed for high IL-12 production show enhanced activity as cancer vaccines is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1039135375
P356DOI10.1007/S00262-008-0648-5
P932PMC publication ID2907477
P698PubMed publication ID19156413
P5875ResearchGate publication ID23804246

P50authorAdam GiermaszQ114575361
P2093author name stringWilliam Gooding
Pawel Kalinski
Julie A Urban
Yutaro Nakamura
Payal Watchmaker
Rachel L Cumberland
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Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokinesQ36366108
Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cellsQ36368860
Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and primingQ36371607
Gene therapy of cancer based on interleukin 12.Q36386455
IL-18-induced CD83+CCR7+ NK helper cellsQ36403560
Helper roles of NK and CD8+ T cells in the induction of tumor immunity. Polarized dendritic cells as cancer vaccinesQ36751608
Enhanced activation of human dendritic cells by inducible CD40 and Toll-like receptor-4 ligationQ40059146
Tumor cell loaded type-1 polarized dendritic cells induce Th1-mediated tumor immunityQ40355233
Lymphocyte responses and cytokinesQ40620203
Cytokine gene therapy of cancer using interleukin-12: murine and clinical trials.Q41261328
Dendritic cells mediate NK cell help for Th1 and CTL responses: two-signal requirement for the induction of NK cell helper functionQ43442797
A novel bulk-culture method for generating mature dendritic cells from mouse bone marrow cells.Q43975812
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Gene therapy of cancer with interleukin-12.Q45863805
Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cellsQ54102042
Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation stateQ57779701
CD8+ T Cell-Dependent Elimination of Dendritic Cells In Vivo Limits the Induction of Antitumor ImmunityQ62230837
IL-4 Is a Mediator of IL-12p70 Induction by Human Th2 Cells: Reversal of Polarized Th2 Phenotype by Dendritic CellsQ62589132
Improved efficacy of dendritic cell vaccines and successful immunization with tumor antigen peptide-pulsed peripheral blood mononuclear cells by coadministration of recombinant murine interleukin-12Q63280965
Granulocyte/macrophage-colony stimulating factor and interleukin-4 expand and activate type-1 dendritic cells (DC1) when administered in vivo to cancer patients.Q64882566
Susceptibility to Leishmania major infection in interleukin-4-deficient miceQ70960225
IL-12-engineered dendritic cells serve as effective tumor vaccine adjuvants in vivoQ71871168
Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cellsQ73035410
Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instructionQ73709048
The role of interleukin-2, interleukin-12, and dendritic cells in cancer therapyQ74148202
IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c miceQ74619595
Dendritic cells require maturation via CD40 to generate protective antitumor immunityQ77186016
Polarized type-1 dendritic cells (DC1) producing high levels of IL-12 family members rescue patient TH1-type antimelanoma CD4+ T cell responses in vitroQ79467943
alpha-type-1 polarized dendritic cells: a novel immunization tool with optimized CTL-inducing activityQ80516665
P433issue8
P921main subjectdendritic cellQ506253
P304page(s)1329-1336
P577publication date2009-01-21
P1433published inCancer Immunology, ImmunotherapyQ5031409
P1476titleType-1 polarized dendritic cells primed for high IL-12 production show enhanced activity as cancer vaccines
P478volume58

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