Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review

scientific article

Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P698PubMed publication ID10956379

P2093author name stringSingh BB
Mishra LC
Dagenais S
P433issue4
P921main subjectWithania somniferaQ852660
P304page(s)334-346
P577publication date2000-08-01
P1433published inAlternative Medicine ReviewQ15279374
P1476titleScientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review
P478volume5

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cites work (P2860)
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Q38813184AshwaMAX and Withaferin A inhibits gliomas in cellular and murine orthotopic models
Q35023273Ashwagandha (Withania somnifera) reverses β-amyloid1-42 induced toxicity in human neuronal cells: implications in HIV-associated neurocognitive disorders (HAND).
Q35978053Ashwagandha root in the treatment of non-classical adrenal hyperplasia
Q37251119Assessment of Cholinergic Properties of Ashwagandha Leaf-Extract in the Amnesic Mouse Brain
Q46306933Attenuation of oxidative damage-associated cognitive decline by Withania somnifera in rat model of streptozotocin-induced cognitive impairment.
Q55281800Ayurvedic Medicine for the Treatment of Dementia: Mechanistic Aspects.
Q36424824Ayurvedic medicinal plants for Alzheimer's disease: a review
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Q36391065Changes in the leaf proteome profile of Withania somnifera (L.) Dunal in response to Alternaria alternata infection
Q31158688Characterization of Withania somnifera leaf transcriptome and expression analysis of pathogenesis-related genes during salicylic acid signaling.
Q80160722Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis
Q37393155Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study
Q64904659Concomitant Inhibition of Cytoprotective Autophagy Augments the Efficacy of Withaferin A in Hepatocellular Carcinoma.
Q47257511Concomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice
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Q35064952Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis
Q37101683Effect of Withania somnifera (L.) Dunal on Sex Hormone and Gonadotropin Levels in Addicted Male Rats
Q41881431Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants
Q41254103Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults
Q53407271Effects of Withania somnifera on Reproductive System: A Systematic Review of the Available Evidence.
Q59793447Effects of an Aqueous Extract of on Strength Training Adaptations and Recovery: The STAR Trial
Q36533492Effects of eight-week supplementation of Ashwagandha on cardiorespiratory endurance in elite Indian cyclists
Q35520129Efficacy & safety evaluation of Ayurvedic treatment (Ashwagandha powder & Sidh Makardhwaj) in rheumatoid arthritis patients: a pilot prospective study.
Q90747352Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study
Q36393561Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults.
Q58601943Elucidating the active interaction mechanism of phytochemicals withanolide and withanoside derivatives with human serum albumin
Q35218471Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor
Q34439695Erosive osteoarthritis: presentation, clinical pearls, and therapy
Q89964048Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook
Q34425281Evaluation of antioxidant potential of Rasayana drugs in healthy human volunteers
Q36242409Evaluation of the bioavailability of major withanolides of Withania somnifera using an in vitro absorption model system.
Q36317162Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial
Q26745772Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies
Q90382869Foliar application of elicitors enhanced the yield of withanolide contents in Withania somnifera (L.) Dunal (variety, Poshita)
Q28551962Functional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model of Parkinson's Disease: Drug Effects of Withania somnifera (Dunal) Administration
Q42654515Functional characterization and differential expression studies of squalene synthase from Withania somnifera.
Q37488585Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin
Q38710667Herbo-mineral supplementation in men with idiopathic oligoasthenoteratospermia : A double blind randomized placebo-controlled trial
Q33826976Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A
Q55180127Hypertension in an Adolescent Secondary to Performance-Enhancement Supplement Use.
Q35206870Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach
Q37223968In Silico Analysis of Microarray-Based Gene Expression Profiles Predicts Tumor Cell Response to Withanolides
Q59350719In Vivo Evaluation of Withania somnifera-Based Indian Traditional Formulation ( Amukkara Choornam), Against Chikungunya Virus-Induced Morbidity and Arthralgia
Q33832474In silico identification of viper phospholipaseA2 inhibitors: validation by in vitro, in vivo studies
Q39672278In vitro protective effects of Withania somnifera (L.) dunal root extract against hydrogen peroxide and β‐amyloid(1–42)‐induced cytotoxicity in differentiated PC12 cells
Q43119866Inhibition of NFkappaB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation
Q33766743Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera's key metabolite withaferin A.
Q39624830LXR-α selectively reprogrammes cancer cells to enter into apoptosis
Q52768377Laboratory assessment of acaricidal activity of Cymbopogon winterianus, Vitex negundo and Withania somnifera extracts against deltamethrin resistant Hyalomma anatolicum.
Q88019123Long term effectiveness of RA-1 as a monotherapy and in combination with disease modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis
Q33853018Mammary cancer chemoprevention by withaferin A is accompanied by in vivo suppression of self-renewal of cancer stem cells
Q36886410Management of tennis elbow by Agnikarma
Q33563815Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer
Q34039548Medicinal Plants and Other Living Organisms with Antitumor Potential against Lung Cancer
Q36557794Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology
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Q40997589Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer
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Q37151195Multimodal Ayurvedic management for Sandhigatavata (Osteoarthritis of knee joints).
Q28486400NADPH-cytochrome P450 reductase: molecular cloning and functional characterization of two paralogs from Withania somnifera (L.) dunal
Q26770401Natural Products as Anti-HIV Agents and Role in HIV-Associated Neurocognitive Disorders (HAND): A Brief Overview
Q39369078Natural withanolide withaferin A induces apoptosis in uveal melanoma cells by suppression of Akt and c-MET activation
Q21143741Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974
Q46010920Neuroprotective effects of Withania somnifera dunal.: A possible mechanism.
Q86182755Neuroprotective role of Withania somnifera root extract in maneb-paraquat induced mouse model of parkinsonism
Q34175625Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A
Q37711241Novel withanolides target medullary thyroid cancer through inhibition of both RET phosphorylation and the mammalian target of rapamycin pathway.
Q52586079Organic cultivation of Ashwagandha with improved biomass and high content of active Withanolides: Use of Vermicompost.
Q47619930Oxidative stress induced NMDA receptor alteration leads to spatial memory deficits in temporal lobe epilepsy: ameliorative effects of Withania somnifera and Withanolide A.
Q38895762PAWR-mediated suppression of BCL2 promotes switching of 3-azido withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells
Q38573788Pharmacologic overview of Withania somnifera, the Indian Ginseng
Q24620472Pharmacological evaluation of Bioactive Principle of Turnera aphrodisiaca
Q37548974Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells
Q64983726Phytochemical Combination PB125 Activates the Nrf2 Pathway and Induces Cellular Protection against Oxidative Injury.
Q38771849Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in DI TNC1 astrocytes
Q88551082Phytochemicals as potential antidotes for targeting NF-κB in rheumatoid arthritis
Q90369643Practical Application of "About Herbs" Website: Herbs and Dietary Supplement Use in Oncology Settings
Q33766685Probing the anticancer mechanism of prospective herbal drug Withaferin A on mammals: a case study on human and bovine proteasomes
Q49070071Propensity of Withania somnifera to Attenuate Behavioural, Biochemical, and Histological Alterations in Experimental Model of Stroke
Q33630185Protection of swimming-induced oxidative stress in some vital organs by the treatment of composite extract of Withania somnifera, Ocimum sanctum and Zingiber officinalis in male rat.
Q33884074Rectal gel application of Withania somnifera root extract expounds anti-inflammatory and muco-restorative activity in TNBS-induced inflammatory bowel disease
Q41202557Reversal of Cadmium-induced Oxidative Stress in Chicken by Herbal Adaptogens Withania Somnifera and Ocimum Sanctum
Q93172097Role of cytokines in combinatorial immunotherapeutics of non-small cell lung cancer through systems perspective
Q28475888Selective killing of cancer cells by Ashwagandha leaf extract and its component Withanone involves ROS signaling
Q36132585Short-form RON overexpression augments benzyl isothiocyanate-induced apoptosis in human breast cancer cells
Q35587729Small molecule anti-angiogenic probes of the ubiquitin proteasome pathway: potential application to choroidal neovascularization
Q48274979Snake Venom PLA2, a Promising Target for Broad-Spectrum Antivenom Drug Development
Q42871834Stability indicating studies on NMITLI 118RT+ (standardized extract of withania somnifera dunal).
Q58098973Standardized phytotherapic extracts rescue anomalous locomotion and electrophysiological responses of TDP-43 Drosophila melanogaster model of ALS
Q37397036Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells
Q39418413Studies on the protective and immunomodulatory efficacy of Withania somnifera along with cisplatin against experimental visceral leishmaniasis
Q36984582Sub-chronic safety evaluation of ayurvedic immunostimulant formulation 'immuforte' in rats in reverse pharmacology
Q47226952Systematic Overview of Bacopa monnieri (L.) Wettst. Dominant Poly-Herbal Formulas in Children and Adolescents
Q34482399Targeting Notch Signaling in Colorectal Cancer
Q35836876Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer
Q49733740The standardized Withania somnifera Dunal root extract alters basal and morphine-induced opioid receptor gene expression changes in neuroblastoma cells.
Q24633116The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin
Q82910201Therapeutic effect of Withania somnifera on pristane-induced model of SLE
Q57168345Third DWF1 paralog in Solanaceae, sterol Δ-isomerase, branches withanolide biosynthesis from the general phytosterol pathway
Q92323466Triethylene glycol-like effects of Ashwagandha (Withania somnifera (L.) Dunal) root extract devoid of withanolides in stressed mice
Q34987033Water extract of ashwagandha leaves limits proliferation and migration, and induces differentiation in glioma cells
Q34828174Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo
Q34316709Withaferin A induces proteasome inhibition, endoplasmic reticulum stress, the heat shock response and acquisition of thermotolerance
Q34253370Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells
Q36901996Withaferin A inhibits in vivo growth of breast cancer cells accelerated by Notch2 knockdown
Q36091623Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice.
Q36488146Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression
Q43113438Withania somnifera Extract Protects Model Neurons from In Vitro Traumatic Injury
Q33586011Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration.
Q50952029Withania somnifera Suppresses Tumor Growth of Intracranial Allograft of Glioma Cells.
Q89937669Withania somnifera extract reduces the invasiveness of MDA-MB-231 breast cancer and inhibits cytokines associated with metastasis
Q33979803Withania somnifera root extract extends lifespan of Caenorhabditis elegans.
Q33739134Withania somnifera targets interleukin-8 and cyclooxygenase-2 in human prostate cancer progression
Q36984280Withania somnifera: From prevention to treatment of cancer
Q41699685Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells.
Q34305025Withanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90
Q42004533WsSGTL1 gene from Withania somnifera, modulates glycosylation profile, antioxidant system and confers biotic and salt stress tolerance in transgenic tobacco
Q28545117β-Amyloid1-42, HIV-1Ba-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide A

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