FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner

scientific article

FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI24921
P932PMC publication ID1224296
P698PubMed publication ID16184196

P50authorDeborah V NovackQ41140630
Steven L. TeitelbaumQ42404516
P2093author name stringJudith M Müller
Roland Schüle
Ju Chen
Haibo Zhao
Bryant Darnay
F Patrick Ross
Hideki Kitaura
Shuting Bai
P2860cites workDistinct molecular mechanism for initiating TRAF6 signallingQ24302174
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREMQ24515126
Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice.Q24534150
RANK is essential for osteoclast and lymph node developmentQ24598872
FHL2, a novel tissue-specific coactivator of the androgen receptorQ24601620
Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificityQ27635130
The LIM domain: regulation by associationQ28137861
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient miceQ28140546
Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signalingQ28141969
Bone resorption by osteoclastsQ28145169
Tumor necrosis factor receptor-associated factors (TRAFs)Q28199382
The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger proteinQ28216196
Identification of the LIM protein FHL2 as a coactivator of beta-cateninQ28216665
The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptorQ28259278
LIM domains: multiple roles as adapters and functional modifiers in protein interactionsQ28271283
The LIM domain: from the cytoskeleton to the nucleusQ28291172
TRAF6 is a signal transducer for interleukin-1Q28291934
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclastsQ28510858
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingQ28513445
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorptionQ28576916
Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and deathQ28609905
Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heartQ32065037
NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritisQ33840418
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclastsQ33939357
The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1.Q34184539
TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology.Q34272380
Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factorQ34346157
The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleusQ34543723
Integrin alphavbeta3 is expressed in selected microvessels after focal cerebral ischemia.Q35782350
Integrins and angiogenesisQ35962963
The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesisQ36371653
FHL2 (SLIM3) is not essential for cardiac development and functionQ39455832
The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleusQ39646594
Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesisQ39714931
c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiationQ39741079
Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-cateninQ40486121
Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanismQ40612839
The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signalingQ41062466
Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular systemQ41749359
A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive functionQ42811314
A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal womenQ46133598
Marrow Stromal Cells and Osteoclast Precursors Differentially Contribute to TNF- -Induced Osteoclastogenesis In VivoQ58085384
The structure of the human LIM protein ACT gene and its expression in tumor cell linesQ73938567
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)2742-2751
P577publication date2005-09-22
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleFHL2 inhibits the activated osteoclast in a TRAF6-dependent manner
P478volume115