Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines

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Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...623831Z
P356DOI10.1371/JOURNAL.PONE.0023831
P932PMC publication ID3166084
P698PubMed publication ID21909361
P5875ResearchGate publication ID51640768

P2093author name stringGuoxin Zhang
Zuhu Huang
Georg F Weber
Rihua Zhang
Xiaolin Pan
P2860cites workStructural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12Q27652199
Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survivalQ33464680
Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation modelQ33623571
RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cellsQ33713013
TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3.Q33754007
Pancreatic cancer spheres are more than just aggregates of stem marker-positive cellsQ34345810
The prognostic molecular markers in hepatocellular carcinomaQ34668320
Proteases in brain tumour progressionQ35541218
Homing and mobilization of hematopoietic stem cells and hematopoietic cancer cells are mirror image processes, utilizing similar signaling pathways and occurring concurrently: circulating cancer cells constitute an ideal target for concurrent treatmQ35566338
Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome.Q36240875
An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma.Q53334223
Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells.Q53667542
Hydrogen peroxide enhances osteopontin expression and matrix metalloproteinase activity in aortic vascular smooth muscle cells.Q54503417
Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs.Q54578574
Stable Overexpression of Smad7 in Human Melanoma Cells Impairs Bone MetastasisQ54976432
A role for matrix metalloproteinases and tumor host interaction in hepatocellular carcinomasQ74189308
An osteopontin-NADPH oxidase signaling cascade promotes pro-matrix metalloproteinase 9 activation in aortic mesenchymal cellsQ83367428
The molecular signature of metastases of human hepatocellular carcinomaQ36279630
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Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancerQ36949589
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Expression analyses of human cleft palate tissue suggest a role for osteopontin and immune related factors in palatal developmentQ37184993
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Functional diversity of SDF-1 splicing variantsQ37415245
New cytokine: stromal derived factor-1.Q37500404
Molecular pathology of early stage chemically induced hepatocarcinogenesisQ37588023
Osteopontin; as a target molecule for the treatment of inflammatory diseasesQ37701469
Genome wide expression profiling identifies genes associated with colorectal liver metastasisQ38516225
Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cellsQ39687919
Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cellsQ39698825
Osteopontin promotes gastric cancer metastasis by augmenting cell survival and invasion through Akt-mediated HIF-1alpha up-regulation and MMP9 activationQ39825484
Circulating bone marrow-derived osteoblast progenitor cells are recruited to the bone-forming site by the CXCR4/stromal cell-derived factor-1 pathwayQ40164723
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cellsQ40277201
Matrix metalloproteinase-2: mechanism and regulation of NF-kappaB-mediated activation and its role in cell motility and ECM-invasion.Q40449809
Roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in metastasis of hepatocellular carcinoma cellsQ41376824
Utility of osteopontin as a biomarker in recurrent epithelial ovarian cancerQ47727649
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
P304page(s)e23831
P577publication date2011-08-31
P1433published inPLOS OneQ564954
P1476titleOsteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines
P478volume6