Mast cells and the neurofibroma microenvironment

scientific article

Mast cells and the neurofibroma microenvironment is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2009-09-242875
P8608Fatcat IDrelease_wo3fdzd5irgbtckouvzgg23lva
P932PMC publication ID2910605
P698PubMed publication ID20233971
P5875ResearchGate publication ID42109047

P2093author name stringFeng-Chun Yang
D Wade Clapp
Karl Staser
P2860cites workThe Hallmarks of CancerQ221226
Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cellsQ24322602
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteinsQ24324729
The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 geneQ24605122
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrowQ24645717
Inflammation and cancerQ24649640
Tumor microenvironment and neurofibromatosis type I: connecting the GAPsQ24654681
The GTPase superfamily: conserved structure and molecular mechanismQ27860524
NF1 tumor suppressor gene function: narrowing the GAPQ28203741
Mast cells are an essential hematopoietic component for polyp developmentQ36288986
Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokinesQ36400929
Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cellsQ37001981
Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation.Q37253335
Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromasQ37332217
Translation of the Philadelphia chromosome into therapy for CML.Q37344094
Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formationQ37383632
The cellular functions of small GTP-binding proteinsQ37821945
Von Recklinghausen neurofibromatosisQ40262766
The c-kit receptor, stem cell factor, and mast cells. What each is teaching us about the others.Q40486326
The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells.Q40821493
Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1-/- cellsQ40842515
The neurofibromatosis type 1 gene and its protein product, neurofibromin.Q40890889
Role for the stem cell factor/KIT complex in Schwann cell neoplasia and mast cell proliferation associated with neurofibromatosisQ41487729
Nf1+/- mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathwayQ42538041
Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosisQ42806305
Inflammatory cells and cancer: think different!Q42944409
Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences of Nf1 deficiency in T-cell development and functionQ44189816
Neurofibromatosis: past, present, and futureQ45012916
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cellsQ46486969
Analysis of vascularity of human neurofibromasQ47957444
Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity.Q48106714
Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis.Q52517404
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.Q52584140
Neurofibromatosis and cancer.Q53539963
Neurofibromatosis type 1Q57868109
The Dominant W 42 Spotting Phenotype Results from a Missense Mutation in the c- kit Receptor KinaseQ67653010
Mast-cell-deficient W/Wv mice exhibit a decreased rate of tumor angiogenesisQ69032163
Cutaneous manifestation of neurofibromatosis: cellular interaction, pigmentation, and mast cellsQ71594074
Possible involvement of c-kit receptor and its ligand in increase of mast cells in neurofibroma tissuesQ72100660
K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cellsQ79718064
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissuesQ28238680
The neurofibromatosis type 1 gene encodes a protein related to GAPQ28301160
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transitionQ28301955
The GTPase superfamily: a conserved switch for diverse cell functionsQ28302983
The prognostic relevance of angiogenesis and mast cells in squamous cell carcinoma of the oesophagusQ28365597
Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cellsQ28504730
Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemiaQ28505914
Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brainQ28506943
Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytesQ28506980
Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cellsQ28508149
The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 miceQ28511045
The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locusQ28512134
Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivoQ28585229
Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cellsQ28586410
Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferaseQ28588037
Mouse models of tumor development in neurofibromatosis type 1Q28591083
Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signalingQ28592228
Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitroQ28594862
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1Q28594951
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21Q28609120
The role of myeloid cells in the promotion of tumour angiogenesisQ29614299
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerQ29618155
Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cellsQ33757962
Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and WQ33920173
Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patientsQ34166560
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cellsQ34265808
The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locusQ34407347
Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.Q34441257
Neurofibromas in NF1: Schwann cell origin and role of tumor environmentQ34509108
Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptorQ34567286
Type 1 neurofibromatosis: selective expression of extracellular matrix genes by Schwann cells, perineurial cells, and fibroblasts in mixed culturesQ34577394
Neurofibromin regulation of ERK signaling modulates GABA release and learningQ34872465
Physical mapping of the von Recklinghausen neurofibromatosis region on chromosome 17.Q35185266
Signal transduction through small GTPases—A tale of two GAPsQ35228011
Mast cell modulation of tumour cell proliferation in rat mammary adenocarcinoma 13762NFQ35984781
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmast cellQ191989
P304page(s)157-164
P577publication date2010-03-16
P1433published inBloodQ885070
P1476titleMast cells and the neurofibroma microenvironment
P478volume116