Anti-MUC1 monoclonal antibody (C595) and docetaxel markedly reduce tumor burden and ascites, and prolong survival in an in vivo ovarian cancer model.

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Anti-MUC1 monoclonal antibody (C595) and docetaxel markedly reduce tumor burden and ascites, and prolong survival in an in vivo ovarian cancer model. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...624405W
P356DOI10.1371/JOURNAL.PONE.0024405
P8608Fatcat IDrelease_twcuml7aznbfre7i2ikf5a3lye
P932PMC publication ID3170300
P698PubMed publication ID21931707
P5875ResearchGate publication ID51655731

P50authorAlan C. PerkinsQ37838612
P2093author name stringYong Li
Li Wang
John H Kearsley
Hongmin Chen
Julia Beretov
Mohammad H Pourgholami
Jingli Hao
Hongtu Chao
P2860cites workCancer statistics, 2010Q27860525
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Tumor, tissue, and plasma pharmacokinetic studies and antitumor response studies of docetaxel in combination with 9-nitrocamptothecin in mice bearing SKOV-3 human ovarian xenograftsQ46934619
A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeatsQ48315228
Intraperitoneal cisplatin and paclitaxel in ovarian cancer.Q53263238
Immunoscintigraphy of ovarian carcinoma using a monoclonal antibody (111In-NCRC48) defining a polymorphic epithelial mucin (PEM) epitopeQ72890618
Use of CA-125 to define progression of ovarian cancer in patients with persistently elevated levelsQ74619168
Expression of MUC1 in primary and metastatic human epithelial ovarian cancer and its therapeutic significanceQ79972618
Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinomaQ80565368
Soluble MUC1 and serum MUC1-specific antibodies are potential prognostic biomarkers for platinum-resistant ovarian cancerQ83774542
Expression of aberrantly glycosylated Mucin‐1 in ovarian cancerQ85212499
Cancer statistics, 2008Q27860585
PARP-1, a determinant of cell survival in response to DNA damageQ28182341
MUC1 cytoplasmic tail: a potential therapeutic target for ovarian carcinomaQ28259350
Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferationQ28266311
Induction of IgG antibodies to MUC1 and survival in patients with epithelial ovarian cancerQ28288802
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisQ28292299
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymeraseQ28302692
Rise and fall of an anti-MUC1 specific antibodyQ28743508
Constitutive and antibody-induced internalization of prostate-specific membrane antigen.Q32015731
A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancerQ34254918
The importance of MUC1 cellular localization in patients with breast carcinoma: an immunohistologic study of 71 patients and review of the literatureQ34273106
Recent advances in the treatment of epithelial ovarian cancerQ34481727
Phase III randomized trial of docetaxel-carboplatin versus paclitaxel-carboplatin as first-line chemotherapy for ovarian carcinoma.Q34552660
A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationshipQ34690734
Part II: chemotherapy for epithelial ovarian cancer-treatment of recurrent diseaseQ34826559
Microtubules, microtubule-interfering agents and apoptosis.Q35219575
Drug delivery and transport to solid tumorsQ35563687
Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralizationQ35753569
Ovarian cancer metastasis: integrating insights from disparate model organismsQ36111930
Treatment of ovarian cancer using intraperitoneal chemotherapy with taxanes: from laboratory bench to bedsideQ36581822
MUC1 expression in primary and metastatic pancreatic cancer cells for in vitro treatment by (213)Bi-C595 radioimmunoconjugateQ36695246
Contribution of membrane mucins to tumor progression through modulation of cellular growth signaling pathwaysQ36752265
Pilot study of vaccination with recombinant CEA-MUC-1-TRICOM poxviral-based vaccines in patients with metastatic carcinomaQ37169042
Beyond chemotherapy: targeted therapies in ovarian cancerQ37399899
Promising tumor-associated antigens for future prostate cancer therapy.Q37523602
Monoclonal antibody targeting MUC1 and increasing sensitivity to docetaxel as a novel strategy in treating human epithelial ovarian cancerQ39632081
Continuous docetaxel chemotherapy improves therapeutic efficacy in murine models of ovarian cancerQ39695801
Effect of the antibody immunotherapy by the anti-MUC1 monoclonal antibody to the oral squamous cell carcinoma in vitroQ39910773
High level of MUC1 in serum of ovarian and breast cancer patients inhibits huHMFG-1 dependent cell-mediated cytotoxicity (ADCC).Q40095351
Albendazole: a potent inhibitor of vascular endothelial growth factor and malignant ascites formation in OVCAR-3 tumor-bearing nude miceQ40301376
In vivo and in vitro inhibition of pancreatic cancer growth by targeted alpha therapy using 213Bi-CHX.A"-C595.Q40388290
An evaluation of cytotoxicity of the taxane and platinum agents combination treatment in a panel of human ovarian carcinoma cell linesQ40407981
Cytotoxicity of PAI2, C595 and Herceptin vectors labeled with the alpha-emitting radioisotope Bismuth-213 for ovarian cancer cell monolayers and clustersQ40408539
Antigenic expression of human metastatic prostate cancer cell lines for in vitro multiple-targeted alpha-therapy with 213Bi-conjugatesQ40508166
C595--a monoclonal antibody against the protein core of human urinary epithelial mucin commonly expressed in breast carcinomasQ42383836
A phase II study of docetaxel in paclitaxel-resistant ovarian and peritoneal carcinoma: a Gynecologic Oncology Group studyQ44315213
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
docetaxelQ420436
monoclonal antibodyQ422248
ovarian cancerQ172341
P304page(s)e24405
P577publication date2011-09-09
P1433published inPLOS OneQ564954
P1476titleAnti-MUC1 monoclonal antibody (C595) and docetaxel markedly reduce tumor burden and ascites, and prolong survival in an in vivo ovarian cancer model
P478volume6

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cites work (P2860)
Q47104633A Mucin1 C-terminal Subunit-directed Monoclonal Antibody Targets Overexpressed Mucin1 in Breast Cancer
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Q28482047In vitro and in vivo prostate cancer metastasis and chemoresistance can be modulated by expression of either CD44 or CD147
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