Angiotensin II sustains brain inflammation in mice via TGF-beta

scientific article

Angiotensin II sustains brain inflammation in mice via TGF-beta is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI41709
P932PMC publication ID2912186
P698PubMed publication ID20628203

P50authorTony Wyss-CorayQ23782672
Michael PlattenQ38799497
Jian LuoQ43291036
P2093author name stringHui Zhang
Lawrence Steinman
Peggy P Ho
Tobias V Lanz
Robert Axtell
Hrishikesh Srinagesh
Zhaoqing Ding
Ankur N Agrawal
P2860cites workProtective effect of transforming growth factor beta 1 on experimental autoimmune diseases in miceQ37468752
Correlation of thrombospondin-1 and transforming growth factor-beta expression with malignancy of gliomaQ40835307
Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts diseaseQ43076168
The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgeneQ43851353
Control of dendritic cell differentiation by angiotensin II.Q44270057
Angiotensin II type 1 receptor interaction is an important regulator for the development of pancreatic fibrosis in miceQ44796893
The non-thiol angiotensin-converting enzyme inhibitor quinapril suppresses inflammatory arthritisQ45048879
The renin-angiotensin system and the developing retinal vasculatureQ45280910
Angiotensin II stimulates the autocrine production of transforming growth factor-beta 1 in adult rat cardiac fibroblastsQ46052970
Suppression of experimental autoimmune uveitis by angiotensin II type 1 receptor blocker telmisartanQ46167652
Angiotensin receptor blockers suppress antigen-specific T cell responses and ameliorate collagen-induced arthritis in miceQ46525969
Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditionsQ46822097
Angiotensin II type 1 receptor expression on human leukocyte subsets: a flow cytometric and RT-PCR study.Q46986151
Angiotensin II induces hypertrophy of human airway smooth muscle cells: expression of transcription factors and transforming growth factor-beta1.Q47999476
Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-beta 1Q48655440
Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injuryQ48840754
Participation of thrombospondin-1 in the activation of latent transforming growth factor-beta in malignant glioma cellsQ48853907
Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse.Q52519170
Evidence that macrophages in atherosclerotic lesions contain angiotensin IIQ77198552
Angiotensin II, transforming growth factor-beta1 and repair in the infarcted heartQ77299992
The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-betaQ77388281
TGF-beta 1 production in radiation nephropathy: role of angiotensin IIQ77759932
Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokinesQ81072711
Role of transforming growth factor beta in human diseaseQ28143408
Regulation of immune responses by TGF-betaQ28271433
TGF-beta: a master of all T cell tradesQ28290413
Thrombospondin-1 is a major activator of TGF-beta1 in vivoQ28513856
Characterisation of a thymic renin-angiotensin system in the transgenic m(Ren-2)27 ratQ28575221
Highly sensitive and specific bioassay for measuring bioactive TGF-betaQ33237082
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.Q33319975
Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infectionQ33843007
Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-betaQ33902166
Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cellsQ34150690
Regulation of blood pressure by the type 1A angiotensin II receptor geneQ34451124
Recent progress towards a molecular understanding of Marfan syndromeQ34465738
The logic of TGFbeta signaling.Q34522372
Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic statesQ35110459
Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegenerationQ35722374
Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animalsQ35820693
Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis.Q36088936
Reversal of acute and chronic synovial inflammation by anti-transforming growth factor betaQ36361126
Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis.Q36370963
T(H)-17 cells in the circle of immunity and autoimmunityQ36765453
Regulation of the renin-angiotensin system in coronary atherosclerosis: a review of the literatureQ37058920
Regulation of T-cell function by endogenously produced angiotensin II.Q37100479
Update on tissue renin-angiotensin systemsQ37139367
Involvement of endogenous tumor necrosis factor alpha and transforming growth factor beta during induction of collagen type II arthritis in miceQ37147228
Deficiency of thrombospondin-1 reduces Th17 differentiation and attenuates experimental autoimmune encephalomyelitisQ37327995
Role of the renin-angiotensin system in autoimmune inflammation of the central nervous systemQ37329566
Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity.Q37329670
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
encephalitisQ199615
P304page(s)2782-2794
P577publication date2010-07-12
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleAngiotensin II sustains brain inflammation in mice via TGF-beta
P478volume120

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cites work (P2860)
Q480118776-Hydroxydopamine induces brain vascular endothelial inflammation
Q24306614A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme
Q41701311A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information.
Q37202385AAV8-Mediated Angiotensin-Converting Enzyme 2 Gene Delivery Prevents Experimental Autoimmune Uveitis by Regulating MAPK, NF-κB and STAT3 Pathways
Q36098738AGTR1 gene variation: association with depression and frontotemporal morphology
Q35173719AT1 receptor antagonism does not influence early radiation-induced changes in microglial activation or neurogenesis in the normal rat brain
Q36148314Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders
Q42697695Acute hypertensive response in patients with intracerebral hemorrhage pathophysiology and treatment
Q103034460Altered astrocytic function in experimental neuroinflammation and multiple sclerosis
Q35827935Angiotensin II AT(1) receptor blockers ameliorate inflammatory stress: a beneficial effect for the treatment of brain disorders
Q36410269Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders
Q43239444Angiotensin II drives the production of tumor-promoting macrophages
Q48546748Angiotensin II type 1 receptor expression in astrocytes is upregulated leading to increased mortality in mice with myocardial infarction-induced heart failure
Q87935400Angiotensin IV is induced in experimental autoimmune encephalomyelitis but fails to influence the disease
Q52342055Angiotensin-converting enzyme in innate and adaptive immunity.
Q58085056Angiotensinogen rs5050 germline genetic variant as potential biomarker of poor prognosis in astrocytoma
Q53653853Anti-inflammatory effects of fimasartan via Akt, ERK, and NFκB pathways on astrocytes stimulated by hemolysate.
Q88956304Astrocytes and the Renin Angiotensin System: Relevance in Disease Pathogenesis
Q33769818Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice
Q22306336Autonomic-Immune-Vascular Interaction: An Emerging Concept for Neurogenic Hypertension
Q34390088Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications
Q38100285Brain and retinal microglia in health and disease: an unrecognized target of the renin-angiotensin system
Q92097275Brain angiotensin type-1 and type-2 receptors: cellular locations under normal and hypertensive conditions
Q47842158Candesartan ameliorates brain inflammation associated with Alzheimer's disease.
Q30528431Candesartan, an angiotensin II AT₁-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice.
Q38461657Cerebroprotective effects of RAS inhibitors: Beyond their cardio-renal actions.
Q37620176Cerebrospinal fluid protein carbonylation identifies oxidative damage in autoimmune demyelination
Q42700774Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression
Q104486531Chronically infused angiotensin II induces depressive-like behavior via microglia activation
Q38781945Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension.
Q50194649Coagulation factors and multiple sclerosis : Key factors in the pathogenesis?
Q35195660Combined renin inhibition/(pro)renin receptor blockade in diabetic retinopathy--a study in transgenic (mREN2)27 rats
Q36699626Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus
Q38116974Current status of renin-aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease
Q38207555Development of therapies for autoimmune disease at Stanford: a tale of multiple shots and one goal
Q58794337Differential effects of angiotensin II type I receptor blockers on reducing intraocular pressure and TGFβ signaling in the mouse retina
Q48643095Direct angiotensin type 2 receptor (AT2R) stimulation attenuates T-cell and microglia activation and prevents demyelination in experimental autoimmune encephalomyelitis in mice
Q34323132Direct pro-inflammatory effects of prorenin on microglia
Q50104275Do statins, ACE inhibitors or sartans improve outcome in primary glioblastoma?
Q26783348Dopamine Receptors and Neurodegeneration
Q99711187Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis
Q93115512ECMO attenuates inflammation response and increases ATPase activity in brain of swine model with cardiac arrest compared with CCPR
Q38021079Effect of angiotensin II type 2 receptor on stroke, cognitive impairment and neurodegenerative diseases
Q49016420Effect of dietary β carotene on cerebral aneurysm and subarachnoid haemorrhage in the brain apo E-/- mice.
Q55516350Effects of Systolic Blood Pressure on Brain Integrity in Multiple Sclerosis.
Q38603674Enalapril treatment discloses an early role of angiotensin II in inflammation- and oxidative stress-related muscle damage in dystrophic mdx mice
Q38781028Evidence to Consider Angiotensin II Receptor Blockers for the Treatment of Early Alzheimer's Disease
Q35878979Exacerbation of autoimmune neuroinflammation by dietary sodium is genetically controlled and sex specific
Q41847076Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats
Q46336800Expression of angiotensin II and its receptors in activated microglia in experimentally induced cerebral ischemia in the adult rats
Q36632049Expression of angiotensinogen and receptors for angiotensin and prorenin in the monkey and human substantia nigra: an intracellular renin-angiotensin system in the nigra
Q36270869Expression of angiotensinogen and receptors for angiotensin and prorenin in the rat and monkey striatal neurons and glial cells.
Q35949121Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34
Q34620012Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor β1 in mice.
Q39485775Heterologous regulation of the cannabinoid type 1 receptor by angiotensin II in astrocytes of spontaneously hypertensive rats
Q54241919High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the Renin Angiotensin system.
Q39115238Immunologic Effects of the Renin-Angiotensin System
Q35819219Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease.
Q37921158LOX-1 and angiotensin receptors, and their interplay
Q43833906LPS antagonism of TGF-β signaling results in prolonged survival and activation of rat primary microglia
Q48267087Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death
Q33831494Losartan prevents acquired epilepsy via TGF-β signaling suppression
Q38965333Macrophages in neuroinflammation: role of the renin-angiotensin-system.
Q38969930Menopause and Parkinson's disease. Interaction between estrogens and brain renin-angiotensin system in dopaminergic degeneration.
Q51070174Modulation of the kallikrein/kinin system by the angiotensin-converting enzyme inhibitor alleviates experimental autoimmune encephalomyelitis.
Q38264237Neuroprotective effects of angiotensin receptor blockers.
Q48103115Neuroprotective mechanism of losartan and its interaction with nimesulide against chronic fatigue stress
Q26998948Neuroprotective mechanisms of the ACE2-angiotensin-(1-7)-Mas axis in stroke
Q37809435New insights into angiotensin receptor actions: from blood pressure to aging
Q35836666Nontraditional roles of angiotensin-converting enzyme
Q48414468Obesity-associated extracellular mtDNA activates central TGFβ pathway to cause blood pressure increase
Q30412966Pro-cognitive properties of T cells
Q37157311Protein kinase Cβ as a therapeutic target stabilizing blood-brain barrier disruption in experimental autoimmune encephalomyelitis
Q54356901Regulation of angiotensinogen by angiotensin II in mouse primary astrocyte cultures.
Q49947511Renin angiotensin system and its role in biomarkers and treatment in gliomas
Q42098043Renin-Angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction
Q27009109Review article: the pathophysiological roles of the renin-angiotensin system in the gastrointestinal tract
Q38260925Rho Kinase and Dopaminergic Degeneration: A Promising Therapeutic Target for Parkinson's Disease
Q57823452Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans
Q28081615Role of neurons and glia in the CNS actions of the renin-angiotensin system in cardiovascular control
Q43554936Role of thrombospondin-1 in the development of kidney diseases
Q36487749Roles of Brain Angiotensin II in Cognitive Function and Dementia
Q24297472Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L
Q37468713Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.
Q33967281TGF-β signaling initiated in dendritic cells instructs suppressive effects on Th17 differentiation at the site of neuroinflammation
Q33771600TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation
Q37316413TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells
Q55007046Targeting Renin-Angiotensin System Against Alzheimer's Disease.
Q36462348Targeting the TGFβ signalling pathway in disease
Q36019970Telmisartan Modulates Glial Activation: In Vitro and In Vivo Studies
Q36136825Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways
Q92069261The Effect of Candesartan Alone and Its Combination With Estrogen on Post-traumatic Brain Injury Outcomes in Female Rats
Q92213495The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis
Q36632900The gene expression profiles of induced pluripotent stem cells from individuals with childhood cerebral adrenoleukodystrophy are consistent with proposed mechanisms of pathogenesis
Q37857982The immunopathophysiology of multiple sclerosis
Q38187467The microfibril hypothesis of glaucoma: implications for treatment of elevated intraocular pressure
Q39250678Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstruction.
Q47243282Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease
Q26823508Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms
Q50104779Transforming growth factor-β in stem cells and tissue homeostasis
Q27468826Type-1 angiotensin receptor signaling in central nervous system myeloid cells is pathogenic during fatal alphavirus encephalitis in mice
Q36630037Wnt/β-catenin signaling and renin-angiotensin system in chronic kidney disease

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