Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH

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Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH is …
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scholarly articleQ13442814

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P819ADS bibcode2002PNAS...99.8330K
P356DOI10.1073/PNAS.102055799
P932PMC publication ID123067
P698PubMed publication ID12060776
P5875ResearchGate publication ID11313167

P50authorWilliam BishaiQ75994202
P2093author name stringSandeep Tyagi
Deepak Kaushal
Robert D Fleischmann
Yukari C Manabe
Jyoti Mehrotra
Tetsuyuki Yoshimatsu
Chiew Ko
Benjamin G Schroeder
Cherise Scott
Liane Carpenter
P2860cites workDeciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceQ22122411
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Pentoxifylline treatment of mice with chronic pulmonary tuberculosis accelerates the development of destructive pathologyQ28361050
Mycobacterium tuberculosis catalase and peroxidase activities and resistance to oxidative killing in human monocytes in vitroQ28369434
Differential expression of 10 sigma factor genes in Mycobacterium tuberculosisQ28486484
The Mycobacterium tuberculosis ECF sigma factor sigmaE: role in global gene expression and survival in macrophagesQ28486647
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyaseQ28486974
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosisQ28487225
Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediatesQ28487325
Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosisQ28487409
Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallinQ28487527
The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosisQ28487558
Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth.Q28487575
Mutational analysis of RsrA, a zinc-binding anti-sigma factor with a thiol-disulphide redox switchQ28504065
sigmaR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2).Q28504075
RsrA, an anti-sigma factor regulated by redox changeQ28504098
Comparative genomics of BCG vaccines by whole-genome DNA microarrayQ29618558
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A mycobacterial extracytoplasmic sigma factor involved in survival following heat shock and oxidative stressQ33992555
Early emergence of CD8(+) T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected miceQ34001403
Roles of the glutathione- and thioredoxin-dependent reduction systems in the Escherichia coli and saccharomyces cerevisiae responses to oxidative stress.Q34052736
Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteriaQ34146531
Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidationQ34207376
Analysis of the Streptomyces coelicolor sigE gene reveals the existence of a subfamily of eubacterial RNA polymerase sigma factors involved in the regulation of extracytoplasmic functionsQ35648817
Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS)Q35656072
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Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridizationQ36558993
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Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infectionQ37347705
Site-specific integration of mycobacteriophage L5: integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette-GuérinQ37477073
Growth of Mycobacterium tuberculosis in a defined medium is very restricted by acid pH and Mg(2+) levelsQ39520439
T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigensQ41141434
Loss of oxyR in Mycobacterium tuberculosisQ41592975
Genetic control of susceptibility to infection with Mycobacterium tuberculosis in miceQ43601029
Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies.Q44729936
Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor/human thioredoxinQ45906743
Progression of chronic pulmonary tuberculosis in mice aerogenically infected with virulent Mycobacterium tuberculosisQ46629613
Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.Q48063219
An outbreak involving extensive transmission of a virulent strain of Mycobacterium tuberculosisQ64133339
Persistent infection with virulent but not avirulent Mycobacterium tuberculosis in the lungs of mice causes progressive pathologyQ71198372
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Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosisQ77399349
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectMycobacterium tuberculosisQ130971
P304page(s)8330-8335
P577publication date2002-06-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleReduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH
P478volume99