An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma

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An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1042000771
P356DOI10.1038/MI.2014.6
P932PMC publication ID4130801
P698PubMed publication ID24518246
P5875ResearchGate publication ID260148827

P50authorNaftali KaminskiQ41048454
Jadranka MilosevicQ42414852
Eugene R BleeckerQ65560413
Serpil C. ErzurumQ99561107
P2093author name stringJ Zhao
A Ray
D A Meyers
P Ray
M T Gladwin
W W Busse
S E Wenzel
J R Tedrow
J B Trudeau
A U Contreras
N Voraphani
P2860cites workCloning of two human thyroid cDNAs encoding new members of the NADPH oxidase familyQ22254073
Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epitheliumQ24316416
15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cellsQ24321415
Oxidative epithelial host defense is regulated by infectious and inflammatory stimuliQ24648460
Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defenseQ28181893
Regulated hydrogen peroxide production by Duox in human airway epithelial cellsQ28304734
Nitrite as a substrate and inhibitor of myeloperoxidase. Implications for nitration and hypochlorous acid production at sites of inflammationQ28376896
Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injuryQ30322719
NO chemical events in the human airway during the immediate and late antigen-induced asthmatic responseQ30454236
Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivationQ33240235
Biological aspects of reactive nitrogen speciesQ33631360
Redox control of asthma: molecular mechanisms and therapeutic opportunitiesQ33668491
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research ProgramQ33725032
EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerizationQ33996985
Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivoQ34009376
The nature of heme/iron-induced protein tyrosine nitrationQ35021938
Oxidative and nitrosative events in asthmaQ35186733
Molecular cloning of the complementary deoxyribonucleic acid for human thyroid peroxidaseQ36434971
Profibrotic role of miR-154 in pulmonary fibrosisQ36539603
Nitric oxide and related enzymes in asthma: relation to severity, enzyme function and inflammationQ36832237
Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators.Q37371096
Asthma phenotypes: the evolution from clinical to molecular approachesQ38007831
Functional consequences of dual oxidase-thyroperoxidase interaction at the plasma membraneQ38341016
Whence nitrotyrosine?Q39737940
Nitration of respiratory epithelial cells by myeloperoxidase depends on extracellular nitriteQ40012404
Inactivation of neuregulin-1 by nitration.Q40230876
Duox2 exhibits potent heme peroxidase activity in human respiratory tract epithelium.Q40232490
Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitrationQ40580109
Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesisQ40764411
Interleukin-13 is a more potent inhibitor of the expression of inducible nitric oxide synthase in smooth muscle cells than in macrophages: a comparison with interleukin-4 and interleukin-10.Q41072796
Effect of IL-4 and IL-13 on IFN-gamma-induced production of nitric oxide in mouse macrophages infected with herpes simplex virus type 2.Q41090130
Association of duoxes with thyroid peroxidase and its regulation in thyrocytes.Q43232723
Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen speciesQ43582913
Eosinophil peroxidase mediates protein nitration in allergic airway inflammation in miceQ43774786
Peroxidase- and nitrite-dependent metabolism of the anthracycline anticancer agents daunorubicin and doxorubicinQ43817034
A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen speciesQ43904660
Spatial mapping of pulmonary and vascular nitrotyrosine reveals the pivotal role of myeloperoxidase as a catalyst for tyrosine nitration in inflammatory diseasesQ44166458
Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen depositionQ44304303
Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite. A potential additional mechanism of nitric oxide-dependent toxicityQ46316617
IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cellsQ46667941
Tyrosine modification by reactive nitrogen species: a closer lookQ46738125
Nitrative stress in refractory asthmaQ46834038
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophilsQ46943421
Increasing diversity of human thyroperoxidase generated by alternative splicing. Characterized by molecular cloning of new transcripts with single- and multispliced mRNAs.Q48271969
Combined Use of Exhaled Hydrogen Peroxide and Nitric Oxide in Monitoring AsthmaQ60221712
Condensed expirate nitrite as a home marker for acute asthmaQ71520271
Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic SocietyQ73286389
Effect of superoxide dismutase on a rabbit model of chronic allergic asthmaQ74416785
Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studiesQ81471173
A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthmaQ82430863
P433issue5
P921main subjectasthmaQ35869
P304page(s)1175-1185
P577publication date2014-02-12
P1433published inMucosal ImmunologyQ15817743
P1476titleAn airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma
P478volume7