B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21

scientific article

B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/INTIMM/DXU001
P932PMC publication ID4133571
P698PubMed publication ID24497611

P50authorJoseph A. TrapaniQ46248485
Constantine S. TamQ55445006
George J WeinerQ61983045
Paul NeesonQ41627173
P2093author name stringHubert Schrezenmeier
Thomas Simmet
Bernd Jahrsdörfer
Magdalena Hagn
Stefanie Lindner
Dorit Fabricius
Thamara Beyer
Sue E Blackwell
Stefan Stilgenbauer
Verena Ebel
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CD86 and CD80 differentially modulate the suppressive function of human regulatory T cellsQ47192084
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Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus.Q51976160
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Allogeneic dendritic cells pulsed with tumor lysates or apoptotic bodies as immunotherapy for patients with early-stage B-cell chronic lymphocytic leukemia.Q54656167
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T-cell responses against chronic lymphocytic leukemia cells: implications for immunotherapyQ74314281
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B-cell lymphomas differ in their responsiveness to CpG oligodeoxynucleotidesQ81474815
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Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion.Q30496008
CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemiaQ33334835
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Perforin and the granule exocytosis cytotoxicity pathwayQ35538157
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Phase I clinical trial of CpG oligonucleotide 7909 (PF-03512676) in patients with previously treated chronic lymphocytic leukemiaQ36222910
Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells.Q36229384
Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunityQ36375304
IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitroQ36591370
From normal to clonal B cells: Chronic lymphocytic leukemia (CLL) at the crossroad between neoplasia and autoimmunityQ37012539
The paradox of CD5-expressing B cells in systemic lupus erythematosusQ37012556
Immunogenic cancer cell death: a key-lock paradigmQ37198125
Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I.Q37225614
IL-21: an executor of B cell fateQ37388253
Immunostimulatory oligodeoxynucleotides induce apoptosis of B cell chronic lymphocytic leukemia cells.Q38333437
Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities.Q39281392
Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cellsQ39501063
A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells.Q39516978
Acute lymphoblastic leukemia cells treated with CpG oligodeoxynucleotides, IL-4 and CD40 ligand facilitate enhanced anti-leukemic CTL responses.Q39551385
Monocyte derived dendritic cells generated by IFN-alpha acquire mature dendritic and natural killer cell properties as shown by gene expression analysisQ39755645
Granzyme B: evidence for a role in the origin of myasthenia gravisQ39954776
Interferon-producing killer dendritic cells provide a link between innate and adaptive immunityQ40323654
Good prognosis cytogenetics in B-cell chronic lymphocytic leukemia is associated in vitro with low susceptibility to apoptosis and enhanced immunogenicityQ40439092
Advances in the biology and treatment of B-cell chronic lymphocytic leukemiaQ40563440
Apoptotic pancreatic tumor cells are superior to cell lysates in promoting cross-priming of cytotoxic T cells and activate NK and gammadelta T cells.Q40737940
B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation.Q42742024
IFN-α enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing.Q43047480
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.Q43517682
Activation-induced cell death of human T-cell subsets is mediated by Fas and granzyme B but is independent of TNF-alpha.Q43792305
P433issue7
P921main subjectB-cell chronic lymphocytic leukemiaQ11829285
P304page(s)383-395
P577publication date2014-02-04
P1433published inInternational ImmunologyQ15710043
P1476titleB-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21
P478volume26

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cites work (P2860)
Q36140670CpG oligodeoxynucleotide CpG-685 upregulates functional interleukin-21 receptor on chronic lymphocytic leukemia B cells through an NF-κB mediated pathway
Q36842259GIFT4 fusokine converts leukemic B cells into immune helper cells
Q38471387IL-21: a pleiotropic cytokine with potential applications in oncology
Q94476088Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment
Q38984569Modeling the chronic lymphocytic leukemia microenvironment in vitro
Q38911219Regulatory B lymphocyte functions should be considered in chronic lymphocytic leukemia
Q28078919The Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses in Organ Transplantation

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