2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is selectively toxic to primary dopaminergic neurons in vitro

scientific article

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is selectively toxic to primary dopaminergic neurons in vitro is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/TOXSCI/KFU060
P932PMC publication ID4133585
P698PubMed publication ID24718704
P5875ResearchGate publication ID261520638

P50authorZeynep Sena AgimQ59695544
Mitali A TambeQ64667671
Jason R CannonQ81199022
P2093author name stringAlison E Director-Myska
Jean-Christophe Rochet
George P McCabe
Kenneth W Turteltaub
Amy M Griggs
Vartika R Mishra
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Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease modelQ47852570
3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and other heterocyclic amines as inhibitors of mitochondrial monoamine oxidases separated from human brain synaptosomesQ49139251
Synthesis and decomposition of an ester derivative of the procarcinogen and promutagen, PhIP, 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine: unusual nitrenium ion chemistryQ50071506
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The identification of [2-(14)C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humansQ77386018
Development and validation of a liquid chromatography-tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) inQ84738101
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Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremorQ24656692
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Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's diseaseQ30573637
A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approachQ31097755
Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s diseaseQ33625539
Neurotoxic in vivo models of Parkinson's disease recent advances.Q33708283
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Eat to live, not live to eat.Q33921521
Blood harmane, blood lead, and severity of hand tremor: evidence of additive effectsQ34024964
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Mapping serum albumin adducts of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by data-dependent tandem mass spectrometryQ34349900
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Single-cell redox imaging demonstrates a distinctive response of dopaminergic neurons to oxidative insultsQ35102002
Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple negative breast tumors in nude miceQ35217821
The role of environmental exposures in neurodegeneration and neurodegenerative diseasesQ35551001
The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's diseaseQ35628604
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Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.Q36553302
The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanismsQ37418038
Modulation of cognition and behavior in aged animals: role for antioxidant- and essential fatty acid-rich plant foodsQ37429328
Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in Parkinson's diseaseQ37559961
Glutamatergic medications for the treatment of drug and behavioral addictionsQ37871133
Dietary pattern analysis and biomarkers of low-grade inflammation: a systematic literature reviewQ38122431
The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).Q38477507
Isolation and characterization of new mutagens from fried ground beefQ38479983
P433issue1
P921main subjectdopamineQ170304
P304page(s)179-189
P577publication date2014-04-09
P1433published inToxicological SciencesQ2446966
P1476title2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is selectively toxic to primary dopaminergic neurons in vitro
P478volume140

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cites work (P2860)
Q49602475Alterations in the nigrostriatal dopamine system after acute systemic PhIP exposure
Q34389874Analysis of Statistical Methods Currently used in Toxicology Journals.
Q28085390Dietary factors in the etiology of Parkinson's disease
Q46274831Harmane-induced selective dopaminergic neurotoxicity in C. elegans
Q38658733Health effects of carbon-containing particulate matter: focus on sources and recent research program results
Q40506281Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana).
Q41535306In vitro exposure of simulated meat-cooking fumes to assess adverse biological effects.
Q90342160Neuromelanin Modulates Heterocyclic Aromatic Amine-Induced Dopaminergic Neurotoxicity
Q90312509PhIP exposure in rodents produces neuropathology potentially relevant to Alzheimer's disease
Q50167571Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons.

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