Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: a phase II Consortium study

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Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: a phase II Consortium study is …
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scholarly articleQ13442814

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P356DOI10.1200/JCO.2010.28.4075
P932PMC publication ID2917213
P698PubMed publication ID20530271

P50authorHenry C PitotQ107054204
Michelle R. MahoneyQ112326955
P2093author name stringJoel Picus
Philip A Philip
Lisa Horvath
Noelle K Loconte
George P Kim
Kyle D Holen
Sam J Lubner
Wei-Peng Yong
Guy Van Hazel
Charles E Erlichman
Jill L Kolesar
P2860cites workPhase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lunQ45309210
Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21.Q46484712
Gallbladder cancer, a different disease that needs individual trialsQ46761599
Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancerQ46972019
The clinicopathologic significance of the expression of vascular endothelial growth factor-C in intrahepatic cholangiocarcinoma.Q53600008
Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cellsQ57424613
One-sample multiple testing procedure for phase II clinical trialsQ70365924
Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse modelQ74086906
Evaluation of VEGF A expression and microvascular density as prognostic factors in extrahepatic cholangiocarcinomaQ80075002
K-ras mutations and benefit from cetuximab in advanced colorectal cancer.Q27851454
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancerQ27860681
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of CanadaQ27860904
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Gemcitabine combined with oxaliplatin (GEMOX) in advanced biliary tract adenocarcinoma: a GERCOR studyQ33362191
Combining gemcitabine and capecitabine in patients with advanced biliary cancer: a phase II trialQ33365628
Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma.Q33382749
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Gemcitabine alone or in combination with cisplatin in patients with advanced or metastatic cholangiocarcinomas or other biliary tract tumours: a multicentre randomised phase II study - The UK ABC-01 StudyQ33385766
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Biliary tract cancers.Q33760399
Phase II study of erlotinib in patients with advanced biliary cancerQ33997258
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Chemotherapy in advanced biliary tract carcinoma: a pooled analysis of clinical trialsQ34576456
Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancerQ34618537
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancerQ36509678
Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptorsQ36623600
A phase II trial of erlotinib in combination with bevacizumab in patients with metastatic breast cancerQ37357251
A phase II study of gemcitabine in combination with oxaliplatin as first-line chemotherapy in patients with inoperable biliary tract cancerQ38496967
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude miceQ40971116
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectpatientQ181600
multicenter clinical trialQ6934595
bevacizumabQ413299
erlotinibQ418369
phase II clinical trialQ42824440
P304page(s)3491-3497
P577publication date2010-06-07
P1433published inJournal of Clinical OncologyQ400292
P1476titleReport of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: a phase II Consortium study
P478volume28

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