Blood-Brain Barrier: Penetration of Morphine, Codeine, Heroin, and Methadone after Carotid Injection

scientific article published on December 1, 1972

Blood-Brain Barrier: Penetration of Morphine, Codeine, Heroin, and Methadone after Carotid Injection is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCIENCE.178.4064.984
P953full work available at URLhttps://syndication.highwire.org/content/doi/10.1126/science.178.4064.984
P698PubMed publication ID5084666

P2093author name stringW. H. Oldendorf
L. Braun
S. Hyman
S. Z. Oldendorf
P2860cites workTransactions of the American Neurological AssociationQ692195
Archivos de biologia y medicina experimentalesQ27709097
Measurement of brain uptake of radiolabeled substances using a tritiated water internal standardQ34053885
Methadone binding to human plasma albuminQ43873575
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injectionQ51116341
Regional blood flow by fractional distribution of indicatorsQ74847408
P433issue4064
P407language of work or nameEnglishQ1860
P921main subjectmorphineQ81225
blood–brain barrierQ221694
P304page(s)984-986
P577publication date1972-12-01
P1433published inScienceQ192864
P1476titleBlood-brain barrier: penetration of morphine, codeine, heroin, and methadone after carotid injection
Blood-Brain Barrier: Penetration of Morphine, Codeine, Heroin, and Methadone after Carotid Injection
P478volume178

Reverse relations

cites work (P2860)
Q94697463Q94697463
Q344354783-Methoxynaltrexone, a selective heroin/morphine-6beta-glucuronide antagonist
Q58601391A computational strategy for finding novel targets and therapeutic compounds for opioid dependence
Q35126056A vaccine strategy that induces protective immunity against heroin
Q90433914Abuse liability of mitragynine assessed with a self-administration procedure in rats
Q36768732Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors
Q43557580Agonists determine the pattern of G-protein activation in mu-opioid receptor-mediated supraspinal analgesia.
Q72961537An analog of ACTH/MSH (4–9), ORG-2766, reduces cerebral uptake of morphine
Q49092610An intravenous technique for the measurement of cerebral vascular extraction fraction in the rat.
Q48831383Attenuation of heroin reward in rats by disruption of the mesolimbic dopamine system
Q58854577Biovector nanoparticles improve antinociceptive efficacy of nasal morphine
Q48469492Blood-brain barrier equilibration of codeine in rats studied with microdialysis
Q48716218Blood-to-brain transfer of various oxicams: effects of plasma binding on their brain delivery
Q48656199Central administration of morphine inhibits brain and liver ornithine decarboxylase activity in neonatal rats: involvement of transcription- and non-transcription-dependent mechanisms
Q52139401Chemical Screening Identifies EUrd as a Novel Inhibitor Against Temozolomide-Resistant Glioblastoma-Initiating Cells.
Q46003086Clonidine transport at the mouse blood-brain barrier by a new H+ antiporter that interacts with addictive drugs.
Q39765636Conditioned taste aversion induced by self-administered drugs: paradox revisited
Q39417530Confirmation of recent heroin abuse: Accepting the challenge
Q52579808Current Challenges and Opportunities in Treating Glioblastoma.
Q43075987Designing Safer Analgesics via μ-Opioid Receptor Pathways
Q38001793Designing prodrugs for the treatment of Parkinson's disease.
Q35892296Developing a vaccine against multiple psychoactive targets: a case study of heroin
Q45060547Development of a Clinically Viable Heroin Vaccine.
Q35161471Differentiating the rapid actions of cocaine
Q37238136Drug disposition in the mammalian eye and brain: a comparison of mechanisms
Q57677287Drug transport across the blood-brain barrier
Q44394303Effects of heroin and its metabolites on schedule-controlled responding and thermal nociception in rhesus monkeys: sensitivity to antagonism by quadazocine, naltrindole and beta-funaltrexamine
Q69542868Effects of methadone-HCl on dorsal root ganglia in organotypic culture
Q34495190Effects of morphine on human pancreatic secretion: studies on pure pancreatic juice
Q39667475Effects of the neuropeptide DG-AVP on morphine and food self-administration by dependent rhesus monkey
Q60451057Efficacy of D,L-methadone in the treatment of glioblastoma in vitro
Q37196317Evidence for the nucleus accumbens as a neural substrate of heroin-induced immune alterations
Q39540769Evidence of active transport involvement in morphine transport via MDCKII and MDCK-PGP cell lines
Q40327837Excretion of drugs in human breast milk
Q36942846First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo
Q39358193Fundamental reaction pathway and free energy profile for butyrylcholinesterase-catalyzed hydrolysis of heroin
Q52291826Heroin and morphine: Aversive and analgesic effects in rats
Q45340080Heroin-assisted treatment in the Netherlands: History, findings, and international context
Q50672428Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties.
Q44856527Impact of environmental and genetic factors on codeine analgesia
Q42555336Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake
Q37960529Improving the transport of chemotherapeutic drugs across the blood-brain barrier
Q35782792In vitro blood-brain barrier models: current and perspective technologies
Q48454791Independent blood-brain barrier transport systems for nucleic acid precursors
Q34352413Influence of hydrocortisone on the mechanical properties of the cerebral endothelium in vitro
Q36479824Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance
Q48148305LAT1-mediated prodrug uptake: a way to breach the blood-brain barrier?
Q37219079Levels of heroin and its metabolites in blood and brain extracellular fluid after i.v. heroin administration to freely moving rats
Q61813333Management of Opioid Addiction With Opioid Substitution Treatments: Beyond Methadone and Buprenorphine
Q30427348Microbubbles coupled to methotrexate-loaded liposomes for ultrasound-mediated delivery of methotrexate across the blood-brain barrier
Q33783467Microinjection of codeine into the region of the caudal ventral respiratory column suppresses cough in anesthetized cats
Q69602745Morphine Concentrations and Survival Periods in Acute Heroin Fatalities
Q39811218Morphine and 5-hydroxytryptamine interactions in rat hypothalamus and pineal body
Q72413542Morphine, but not diacetyl morphine (heroin), possesses opiate antagonist activity in the mouse vas deferens
Q30385033Multiple sessions of liposomal doxorubicin delivery via focused ultrasound mediated blood-brain barrier disruption: a safety study.
Q37028008Nicotine Increases Codeine Analgesia Through the Induction of Brain CYP2D and Central Activation of Codeine to Morphine.
Q48793216On the partition of ampholytes: application to blood-brain distribution
Q37364459Opiate-agonist induced taste aversion learning in the Fischer 344 and Lewis inbred rat strains: evidence for differential mu opioid receptor activation
Q92626719Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids
Q39285381Opioids and the blood-brain barrier: a dynamic interaction with consequences on drug disposition in brain.
Q48098914P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells
Q43537321PHARMACOKINETICS In the rat of the hallucinogenic alkaloids harmine and harmaline
Q55022470Pain Therapy Guided by Purpose and Perspective in Light of the Opioid Epidemic.
Q26852773Pathways and progress in improving drug delivery through the intestinal mucosa and blood-brain barriers
Q33783748Pathways for small molecule delivery to the central nervous system across the blood-brain barrier
Q34489836Peptide drug modifications to enhance bioavailability and blood-brain barrier permeability.
Q57374255Peripheral inflammatory hyperalgesia modulates morphine delivery to the brain: a role for P-glycoprotein
Q33999749Permeability changes in the blood-brain barrier: causes and consequences
Q38353145Permeability of the Blood-Brain Barrier: Molecular Mechanism of Transport of Drugs and Physiologically Important Compounds
Q37264538Pharmacogenetic insights into codeine analgesia: implications to pediatric codeine use.
Q44302066Pharmacokinetic modeling of subcutaneous heroin and its metabolites in blood and brain of mice
Q49108658Pharmacokinetic-pharmacodynamic modelling of morphine transport across the blood-brain barrier as a cause of the antinociceptive effect delay in rats--a microdialysis study
Q57677413Pharmacokinetics of [3H]Biotin Bound to Different Avidin Analogues
Q48716326Pharmacological Effects of a Monoclonal Antibody against 6-Monoacetylmorphine upon Heroin-Induced Locomotor Activity and Pharmacokinetics in Mice.
Q48638229Pharmacological Implications of the Conformation of the Methadone Base
Q40139437Pharmacosexology Update: Heroin and Sexual Function
Q73605651Phenotypic and functional assessments of immune status in the rat spleen following acute heroin treatment
Q52289054Population pharmacokinetics of heroin and its major metabolites.
Q44247350Possible mechanism involved in the anticonvulsant action of butorphanol in mice
Q36383315Post heroin dose tissue distribution of 6-monoacetylmorphine (6-MAM) with MALDI imaging
Q34129781Prescription drug abuse: insight into the epidemic.
Q37150860Prodrug approaches for CNS delivery
Q37193593Progress in drug delivery to the central nervous system by the prodrug approach.
Q39238906Reaction pathways and free energy profiles for cholinesterase-catalyzed hydrolysis of 6-monoacetylmorphine
Q52534596Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1.
Q35580984Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids
Q37103059Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats
Q48482517Selective changes in the permeability of the blood‐brain barrier after pharmacological or surgical deafferentation
Q35681802Street drug abuse leading to critical illness
Q52317568Structurally-Related Kappa Opioid Receptor Agonists with Substantial Differential Signaling Bias: Neuroendocrine and Behavioral Effects in C57BL6 Mice.
Q49172338Study with positron emission tomography of the osmotic opening of the dog blood-brain barrier for quinidine and morphine
Q35688659Supplemental morphine infusion into the posterior ventral tegmentum extends the satiating effects of self-administered intravenous heroin
Q90264061Synthesis and Evaluations of Novel Apocynin Derivatives as Anti-Glioma Agents
Q53275431Tandem DART™ MS Methods for Methadone Analysis in Unprocessed Urine.
Q40373095The acute disposition of (R)- and (s)-methadone in brain and lung of sheep
Q66884851The blood-brain barrier
Q48394325The effect of methadone on fetal brain function
Q39433076The influence of active transport systems on morphine -6-glucuronide transport in MDCKII and MDCK-PGP cells
Q41823871The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice.
Q36329172The scientific basis for analgesic use in dentistry
Q38478413Transporter-Mediated Disposition of Opioids: Implications for Clinical Drug Interactions
Q28539271Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system
Q33827984Vector-mediated delivery of 125I-labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer disease amyloid of the A beta 1-40/vector complex
Q34239620Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo
Q81093454[The role of morphine-6-glucuronide during longterm administration of morphine.].

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