Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions.

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Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions. is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...626143W
P356DOI10.1371/JOURNAL.PONE.0026143
P8608Fatcat IDrelease_wvgjca3lmfaofiffnognibpjry
P932PMC publication ID3191176
P698PubMed publication ID22022540
P5875ResearchGate publication ID51737872

P50authorJinhai HuangQ61139401
Robert P. KimberlyQ41183568
P2093author name stringJeffrey C Edberg
Xiulong Xu
Jianming Wu
Fenglong Xie
Andrew W Gibson
Lena Al-Harthi
Maureen H Richards
Rui Lin
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Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammationQ28248826
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A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancerQ28271385
Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligandQ28513283
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Th1 CD4+ lymphocytes delete activated macrophages through the Fas/APO-1 antigen pathwayQ33766466
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TCF: Lady Justice casting the final verdict on the outcome of Wnt signallingQ34122210
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Fas ligand expression in primary colon adenocarcinomas: evidence that the Fas counterattack is a prevalent mechanism of immune evasion in human colon cancerQ59881664
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Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulationQ73046111
Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cellsQ73935008
The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survivalQ74286666
A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activationQ77115244
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Viral IFN-regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand promoterQ77522390
Induction of specific T cell tolerance by Fas ligand-expressing antigen-presenting cellsQ78109619
TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCR beta and TCR delta enhancersQ95815011
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Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivoQ34486226
Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell deathQ34795697
Fas ligand expression in colon cancer: a possible mechanism of tumor immune privilegeQ35045303
Expression of Fas ligand by human gastric adenocarcinomas: a potential mechanism of immune escape in stomach cancerQ35354010
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The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligandQ36367323
Fas ligand triggers pulmonary silicosisQ36369388
FASL -844C polymorphism is associated with increased activation-induced T cell death and risk of cervical cancer.Q36403535
Fas ligand mediates immune privilege and not inflammation in human colon cancer, irrespective of TGF-beta expression.Q36671108
Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?Q37364901
Lymphocyte apoptosis induced by Fas ligand- expressing ovarian carcinoma cells. Implications for altered expression of T cell receptor in tumor-associated lymphocytesQ37383034
Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver.Q37391035
FASLG polymorphism is associated with cancer riskQ37464413
Human lung carcinomas express Fas ligand.Q41120854
B cells in systemic autoimmune disease: recent insights from Fas-deficient mice and men.Q41312443
TCF/LEF factor earn their wingsQ41684115
Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory resQ42020354
A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patientsQ42434981
Transcriptional regulation of the human FasL promoter-enhancer regionQ42450959
The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structuresQ42459873
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation.Q42830166
Clincal, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosisQ44455328
Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the geneQ46906570
Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas.Q46925453
Polymorphisms of death pathway genes FAS and FASL in esophageal squamous-cell carcinomaQ47230945
A newly identified response element in the CD95 ligand promoter contributes to optimal inducibility in activated T lymphocytesQ47757477
The Fas counterattack in vivo: apoptotic depletion of tumor-infiltrating lymphocytes associated with Fas ligand expression by human esophageal carcinoma.Q48032094
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)e26143
P577publication date2011-10-11
P1433published inPLOS OneQ564954
P1476titleHuman FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions
P478volume6

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cites work (P2860)
Q87098038Association of genetic variants in apoptosis genes FAS and FASL with radiation-induced late toxicity after prostate cancer radiotherapy
Q42286900Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner
Q86882836LRP5 and plasma cholesterol levels modulate the canonical Wnt pathway in peripheral blood leukocytes
Q89248716T-cell factor (TCF/LEF1) binding elements (TBEs) of FasL (Fas ligand or CD95 ligand) bind and cluster Fas (CD95) and form complexes with the TCF-4 and b-catenin transcription factors in vitro and in vivo which result in triggering cell death and/or
Q36739216The Wnt/β-catenin/T-cell factor 4 pathway up-regulates high-mobility group A1 expression in colon cancer
Q43622589VEGFA rSNPs, transcriptional factor binding sites and human disease

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