Secreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions

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Secreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions is …
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scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...625678A
P356DOI10.1371/JOURNAL.PONE.0025678
P932PMC publication ID3198733
P698PubMed publication ID22031818
P5875ResearchGate publication ID51749569

P50authorMehrdad ArjomandiQ57321043
P2093author name stringHofer Wong
Amritha Yellamilli
Aneesh Donde
Wilfred Raymond
Jessica Frelinger
P2860cites workPost-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implicationsQ24534917
Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritisQ24632662
The cDNA and derived amino acid sequence for human osteopontinQ24635888
Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cellsQ24651037
Osteopontin prevents monocyte recirculation and apoptosisQ24653039
Role of osteopontin in neutrophil functionQ24655335
OsteopontinQ28140484
Osteopontin, a substrate for transglutaminase and Factor XIII activityQ46850555
Post-translational modification and proteolytic processing of urinary osteopontinQ46855720
Structural requirements for alpha 9 beta 1-mediated adhesion and migration to thrombin-cleaved osteopontinQ47838161
Osteopontin is involved in migration of eosinophils in asthmaQ47923303
Osteopontin: its transglutaminase-catalyzed posttranslational modifications and cross-linking to fibronectin.Q52217585
Gender difference in airway hyperresponsiveness in smokers with mild COPD. The Lung Health Study.Q52369865
Osteopontin function in pathology: lessons from osteopontin-deficient mice.Q52534780
Osteopontin is expressed and functional in human eosinophils.Q54462126
Osteopontin inhibits nitric oxide production and cytotoxicity by activated RAW264.7 macrophages.Q54581979
Exaggerated Left Ventricular Dilation and Reduced Collagen Deposition After Myocardial Infarction in Mice Lacking OsteopontinQ61632678
Differential effects of osteopontin on the cytotoxic activity of macrophages from young and old miceQ71707176
Identification of two phosphorylation motifs in bovine osteopontinQ72733067
Single cell analysis of intracellular osteopontin in osteogenic cultures of fetal rat calvarial cellsQ73023706
Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunityQ73406029
Identification of dual alpha 4beta1 integrin binding sites within a 38 amino acid domain in the N-terminal thrombin fragment of human osteopontinQ73694096
Enhanced local production of osteopontin in rheumatoid jointsQ78359917
Osteopontin upregulation and polymerization by transglutaminase 2 in calcified arteries of Matrix Gla protein-deficient miceQ79451630
Osteopontin promotes integrin activation through outside-in and inside-out mechanisms: OPN-CD44V interaction enhances survival in gastrointestinal cancer cellsQ79856285
Osteopontin induces airway remodeling and lung fibroblast activation in a murine model of asthmaQ83200070
The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating diseaseQ28207482
Autoantibodies to osteopontin in patients with osteoarthritis and rheumatoid arthritisQ28208310
The Role of osteopontin in lung diseaseQ28210480
Expression of osteopontin at sites of bone erosion in a murine experimental arthritis model of collagen-induced arthritis: possible involvement of osteopontin in bone destruction in arthritisQ28214727
Osteopontin deficiency protects against airway remodeling and hyperresponsiveness in chronic asthmaQ28235926
Role of osteopontin in hepatic neutrophil infiltration during alcoholic steatohepatitisQ28249677
Osteopontin expression and relation to disease severity in human asthmaQ28285703
Higher neutrophil infiltration mediated by osteopontin is a likely contributing factor to the increased susceptibility of females to alcoholic liver diseaseQ28294082
Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsetsQ28298064
Protective effects of monoclonal antibody to VLA-4 on leukocyte adhesion and course of disease in adjuvant arthritis in ratsQ28299757
Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1.Q28509843
Tissue transglutaminase and its substrates in boneQ28573074
The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1Q28647112
The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontinQ28647119
Polymeric osteopontin employs integrin alpha9beta1 as a receptor and attracts neutrophils by presenting a de novo binding siteQ30487764
Cross-linking of osteopontin by tissue transglutaminase increases its collagen binding propertiesQ31937983
Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypesQ33522235
Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaquesQ33904134
Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesisQ34325799
The mouse osteopontin gene. Expression in monocytic lineages and complete nucleotide sequenceQ34859278
Essential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritisQ35140465
Polymorphism in Osteopontin Gene (SPP1) Is Associated with Asthma and Related Phenotypes in a Puerto Rican PopulationQ35664965
Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivoQ35763795
Osteopontin and cardiovascular systemQ36669169
Altered wound healing in mice lacking a functional osteopontin gene (spp1).Q37380282
Osteopontin and allergic disease: pathophysiology and implications for diagnostics and therapyQ37821498
Physiological properties and differential glycosylation of phosphorylated and nonphosphorylated forms of osteopontin secreted by normal rat kidney cellsQ38338606
Enhanced osteopontin expression in a murine model of allergen-induced airway remodellingQ40078043
Enhanced biological activity of polymeric osteopontinQ40127298
Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation.Q40697813
Molecular and cellular basis of genetic resistance to bacterial infection: the role of the early T-lymphocyte activation-1/osteopontin gene.Q40716057
Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontinQ40864152
Analysis of the alpha4beta1 integrin-osteopontin interactionQ40868329
In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expressionQ41136343
The immunology of Eta-1/osteopontinQ41276481
Asthma: a dynamic disease of inflammation and repair.Q41562664
Localization of transglutaminase-reactive glutamine residues in bovine osteopontin.Q41770359
Increased levels of osteopontin in sputum supernatant in severe refractory asthmaQ42921926
Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitroQ43422643
Sputum induction and bronchoscopy for assessment of ozone-induced airway inflammation in asthmaQ46839848
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P4510describes a project that usesImageJQ1659584
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectasthmaQ35869
P304page(s)e25678
P577publication date2011-10-21
P1433published inPLOS OneQ564954
P1476titleSecreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions
P478volume6

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cites work (P2860)
Q37439142A holistic approach to dissecting SPARC family protein complexity reveals FSTL-1 as an inhibitor of pancreatic cancer cell growth
Q35650058Inflammatory and repair pathways induced in human bronchoalveolar lavage cells with ozone inhalation
Q92421743Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight
Q89489925Osteopontin contributes to late-onset asthma phenotypes in adult asthma patients
Q38095807RNA interference in the treatment of colon cancer
Q48177889Sodium butyrate has anti-proliferative, pro-differentiating, and immunomodulatory effects in osteosarcoma cells and counteracts the TNFα-induced low-grade inflammation.
Q37406648Transglutaminse 2 and EGGL, the protein cross-link formed by transglutaminse 2, as therapeutic targets for disabilities of old age.

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