Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain.

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Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain. is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.17-04-01226.1997
P932PMC publication ID6793739
P698PubMed publication ID9006968

P2093author name stringD Piomelli
E di Tomaso
H Cadas
P2860cites workIsotope dilution mass spectrometric measurements indicate that arachidonylethanolamide, the proposed endogenous ligand of the cannabinoid receptor, accumulates in rat brain tissue post mortem but is contained at low levels in or is absent from freshQ48962059
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Enzymatic synthesis of anandamide, an endogenous cannabinoid receptor ligand, through N-acylphosphatidylethanolamine pathway in testis: involvement of Ca(2+)-dependent transacylase and phosphodiesterase activitiesQ70929217
Strategy of glycerolipid separation and quantitation by complementary analytical techniques. Plenary lectureQ71231181
Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brainQ71583888
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Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent processQ71693466
Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamideQ71743278
Tumor lipids: Metabolic relationships derived from structural analyses of acyl, alkyl, and alk-1-enyl moieties of neutral glycerides and phosphoglyceridesQ72393705
The effect of long-chain N-acylethanolamines on some membrane-associated functions of neuroblastoma C1300 N18 cellsQ72551970
Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterizationQ72631582
Cannabinoid receptor localization in brainQ24558751
A simple method for the isolation and purification of total lipides from animal tissuesQ25939009
Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonistQ28262546
Isolation and structure of a brain constituent that binds to the cannabinoid receptorQ29547476
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic studyQ29615905
Formation and inactivation of endogenous cannabinoid anandamide in central neuronsQ29620558
Properties of rat liver N-acylethanolamine amidohydrolaseQ34200418
Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamideQ34309026
The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neuronsQ34380089
Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranesQ35592076
Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transductionQ36482564
Leukotrienes in the rat central nervous systemQ37571714
N-acylated glycerophospholipids and their derivativesQ37793330
Health aspects of cannabisQ39238279
Cannabinoid pharmacologyQ39741984
Regional distribution of substance P in the spinal cord and nerve roots of the cat and the effect of dorsal root sectionQ39923482
A method for concurrent measurement of picomole quantities of acetylcholine, choline, dopamine, norepinephrine, serotonin, 5-hydroxytryptophan, 5-hydroxyindoleacetic acid, tryptophan, tyrosine, glycine, aspartate, glutamate, alanine, and gamma-aminoQ40323950
Pharmacology of cannabinoid receptorsQ40437020
The N-acylation-phosphodiesterase pathway and cell signallingQ41016506
Distribution of vasoactive intestinal polypeptide in the rat and mouse brainQ41160101
Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells.Q41529589
α-Methyl-p-tyrosine inhibits the production of free arachidonic acid and diacylglycerols in brain after a single electroconvulsive shockQ41701096
Metabolism of unique diarachidonoyl and linoleoylarachidonoyl species of ethanolamine and choline phosphoglycerides in rat testesQ42225655
Localization of cannabinoid receptor mRNA in rat brainQ42510202
Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat.Q42553964
N-acylethanolamine phospholipid metabolism in normal and ischemic rat brainQ44269681
Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP.Q44596651
The pharmacological activity of anandamide, a putative endogenous cannabinoid, in miceQ45087565
The ATP- and CoA-independent synthesis of arachidonoylethanolamide. A novel mechanism underlying the synthesis of the endogenous ligand of the cannabinoid receptorQ48121956
Isolation and identification of lipoxygenase products from the rat central nervous systemQ48171621
Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclaseQ48251232
Primary culture of identified neurons from the visual cortex of postnatal rats.Q48292813
Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituentQ48332786
Cannabinoids modulate potassium current in cultured hippocampal neurons.Q48388103
Effects of ischemia on free fatty acids and diacylglycerols in developing rat brain.Q48537308
Identification of two molecular species of rat brain phosphatidylcholine that rapidly incorporate and turn over arachidonic acid in vivo.Q48909794
Membrane localization of N-acylphosphatidylethanolamine in central neurons: studies with exogenous phospholipases.Q48924656
Brain cannabinoids in chocolate.Q48940587
Transacylase-mediated and phosphodiesterase-mediated synthesis of N-arachidonoylethanolamine, an endogenous cannabinoid-receptor ligand, in rat brain microsomes. Comparison with synthesis from free arachidonic acid and ethanolamine.Q48942589
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcannabinoidsQ422936
P304page(s)1226-1242
P577publication date1997-02-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleOccurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain
P478volume17

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