The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

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The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors is …
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scholarly articleQ13442814

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P356DOI10.1172/JCI1269
P932PMC publication ID508566
P698PubMed publication ID9435299
P5875ResearchGate publication ID13795775

P2093author name stringD M Roden
G R Wilkinson
B Leake
M F Fromm
R B Kim
A J Wood
C Wandel
P2860cites workAntiviral properties of Ro 31-8959, an inhibitor of human immunodeficiency virus (HIV) proteinaseQ28325776
Biochemistry of multidrug resistance mediated by the multidrug transporterQ29616476
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sitesQ33832954
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugsQ34059522
Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833Q34065489
P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cellsQ34538994
Expression of a multidrug-resistance gene in human tumors and tissuesQ34586576
Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytesQ35608569
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestineQ36031211
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugsQ37355653
P-glycoprotein and pharmacokineticsQ40532601
The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applicationsQ40947744
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Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisersQ41078148
Clinical trials of P-glycoprotein reversal in solid tumoursQ41078214
HIV-1 protease inhibitors. A review for cliniciansQ41303053
Transmembrane P-glycoprotein (P-gp/P-170) in HIV infection: analysis of lymphocyte surface expression and drug-unrelated function.Q41322435
Inhibition of human immunodeficiency virus type 1 replication in cytokine-stimulated monocytes/macrophages by combination therapyQ42275470
Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoproteinQ42552510
Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.Q42930123
Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. AIDS Clinical Trials GroupQ45771512
Brain viral burden in HIV infection.Q46003548
Measurement of CNS HIV burden and its association with neurologic damageQ48228478
A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir).Q52306238
Decreased biotolerability for ivermectin and cyclosporin a in mice exposed to potent P‐glycoprotein inhibitorsQ52537121
Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohistochemistryQ71467046
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectHIVQ15787
P304page(s)289-294
P577publication date1998-01-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleThe drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
P478volume101