A novel mechanism of skin tumor promotion involving interferon-gamma (IFNγ)/signal transducer and activator of transcription-1 (Stat1) signaling

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A novel mechanism of skin tumor promotion involving interferon-gamma (IFNγ)/signal transducer and activator of transcription-1 (Stat1) signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/MC.22132
P932PMC publication ID4139479
P698PubMed publication ID24464587

P50authorErika L. AbelQ46619368
P2093author name stringJohn DiGiovanni
Everardo Macias
Linda Beltran
Tianyi Cheng
Ronald Bozeman
P2860cites workInterferon-γ: an overview of signals, mechanisms and functionsQ28207081
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STATs and gene regulationQ29547796
Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral diseaseQ29615967
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathwayQ29615968
IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicityQ29620119
Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiationQ33565458
Functional roles of STAT family proteins: lessons from knockout miceQ33643949
Targeted disruption of stat3 reveals a major role for follicular stem cells in skin tumor initiation.Q33705396
Rapamycin is a potent inhibitor of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetateQ33705425
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IL-10 elicits IFNγ-dependent tumor immune surveillance.Q34240935
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Down-regulation of protein kinase Cδ inhibits inducible nitric oxide synthase expression through IRF1Q34551021
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Cooperation between Stat3 and Akt signaling leads to prostate tumor development in transgenic mice.Q34633681
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Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaBQ35812229
Multistage carcinogenesis in mouse skinQ35853804
Energy balance modulates mouse skin tumor promotion through altered IGF-1R and EGFR crosstalkQ36351302
Role of interferon regulatory factor 1 in induction of nitric oxide synthaseQ36363736
Interferon regulatory factor (IRF)-1 and IRF-2 regulate interferon gamma-dependent cyclooxygenase 2 expressionQ36368615
Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytesQ36375547
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IFN-gamma-dependent type 1 immunity is crucial for immunosurveillance against squamous cell carcinoma in a novel mouse carcinogenesis model.Q45976146
IFNgamma promotes papilloma development by up-regulating Th17-associated inflammationQ46108789
Promoter independence as a feature of most skin papillomas in SENCAR mice.Q46156854
Involvement of prostaglandin E2 in ornithine decarboxylase induction by a tumor-promoting agent, 7-bromomethylbenz[a]anthracene, in mouse epidermisQ46227554
Activation of epidermal akt by diverse mouse skin tumor promotersQ46825762
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Structure-activity relationships for epidermal ornithine decarboxylase induction and skin tumor promotion by anthrones.Q53520961
Tumor promoting activity of 1,8-dihydroxy-3-methyl-9-anthrone (chrysarobin) in female SENCAR mice.Q53561593
Prognostic significance of phosphorylated STAT-1 expression in premenopausal and postmenopausal patients with invasive breast cancer.Q54530883
Characterization of skin tumor promotion and progression by chrysarobin in SENCAR miceQ70344347
[Dianthrones of pharmacologically important hydroxyanthraquinones]Q78780346
IFN-gamma primes macrophages for enhanced TNF-alpha expression in response to stimulatory and non-stimulatory amounts of microparticulate beta-glucanQ81574540
Steroid-like signalling by interferons: making sense of specific gene activation by cytokinesQ36431134
Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesisQ36459962
Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent miceQ36497106
IRF-1 is required for full NF-kappaB transcriptional activity at the human immunodeficiency virus type 1 long terminal repeat enhancerQ36498248
Unphosphorylated STAT1 promotes sarcoma development through repressing expression of Fas and bad and conferring apoptotic resistanceQ36588875
STAT1 as a key modulator of cell deathQ36644901
JAK-STAT signaling: from interferons to cytokinesQ36821751
Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseasesQ36865332
Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesisQ36869961
An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancerQ36985056
Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis.Q37104021
Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B.Q37108918
Roles of unphosphorylated STATs in signalingQ37118445
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Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genesQ37206449
IFNgamma signaling-does it mean JAK-STAT?Q37301934
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesisQ37486563
The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteinsQ37821935
Non-melanoma skin cancer: carcinogenesis and chemopreventionQ38088099
How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 geneQ38309989
Tumor-promoting role of signal transducer and activator of transcription (Stat)1 in late-stage melanoma growth.Q38507290
Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesionsQ39609105
Role of stat3 in skin carcinogenesis: insights gained from relevant mouse modelsQ39658067
Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesisQ40093549
STAT1 acts as a tumor promoter for leukemia developmentQ40255535
Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesisQ40262816
IFN-gamma and its receptor subunit IFNGR1 are recruited to the IFN-gamma-activated sequence element at the promoter site of IFN-gamma-activated genes: evidence of transactivational activity in IFNGR1.Q40265502
The effect of IFN-gamma and TNF-alpha on the NADPH oxidase system of human colostrum macrophages, blood monocytes, and THP-1 cellsQ40369589
An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cellsQ40517735
Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesisQ40687138
IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell lineQ40828168
IFN-gamma and IL-4 differently regulate inducible NO synthase gene expression through IRF-1 modulation.Q40869772
IFN-gamma induces IL-12 mRNA expression by a murine macrophage cell line, J774.Q41487690
The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs).Q41619482
IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient miceQ41841012
Multiple signaling pathways are responsible for prostaglandin E2-induced murine keratinocyte proliferationQ42142390
Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB.Q42439020
Molecular mechanisms of mouse skin tumor promotionQ42589687
Activation of multiple growth regulatory genes following inducible expression of IRF-1 or IRF/RelA fusion proteinsQ42835212
Nramp1 functionality increases inducible nitric oxide synthase transcription via stimulation of IFN regulatory factor 1 expressionQ43664582
Role of cytokines and Jak3/Stat3 signaling in the 1,2-dimethylhydrazine dihydrochloride-induced rat model of colon carcinogenesis: early target in the anticancer strategy.Q43829850
Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesisQ44826931
P433issue8
P921main subjectTumor promotionQ7852681
P304page(s)642-653
P577publication date2014-01-25
P1433published inMolecular CarcinogenesisQ15724597
P1476titleA novel mechanism of skin tumor promotion involving interferon-gamma (IFNγ)/signal transducer and activator of transcription-1 (Stat1) signaling
P478volume54

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cites work (P2860)
Q40073958A recombinant fusion protein consisting of West Nile virus envelope domain III fused in-frame with equine CD40 ligand induces antiviral immune responses in horses
Q36029673Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate
Q36629583Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
Q27304386Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review
Q91893710Overexpression of TC-PTP in murine epidermis attenuates skin tumor formation
Q36326865Twist1 regulates keratinocyte proliferation and skin tumor promotion

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