Glial cells suppress postencephalitic CD8+ T lymphocytes through PD-L1.

scientific article

Glial cells suppress postencephalitic CD8+ T lymphocytes through PD-L1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/GLIA.22701
P932PMC publication ID4141010
P698PubMed publication ID24890099

P2093author name stringJames R Lokensgard
Shuxian Hu
Wen S Sheng
Scott J Schachtele
Manohar B Mutnal
P2860cites workB7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretionQ22010866
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Reduced lymphocyte infiltration during cytomegalovirus brain infection of interleukin-10-deficient miceQ33925866
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Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity.Q34018474
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Two antigenic peptides from genes m123 and m164 of murine cytomegalovirus quantitatively dominate CD8 T-cell memory in the H-2d haplotypeQ34327234
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Memory T cells persisting in the brain following MCMV infection induce long-term microglial activation via interferon-γ.Q35476157
Dysregulated interferon-gamma responses during lethal cytomegalovirus brain infection of IL-10-deficient miceQ36259486
Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positiveQ36361537
Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis.Q36535632
Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungsQ36903040
CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunityQ36919192
PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cellsQ36986702
Prolonged microglial cell activation and lymphocyte infiltration following experimental herpes encephalitisQ37037960
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Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89.Q40130785
Bystander killing of neurons by cytotoxic T cells specific for a glial antigen.Q40339932
The central nervous system as an immunocompetent organ: role of glial cells in antigen presentationQ41075467
IFN-γ-induced increase in the mobility of MHC class II compartments in astrocytes depends on intermediate filamentsQ41894369
Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxicity in the mouse brainQ42461923
The majority of infiltrating CD8 T lymphocytes in multiple sclerosis lesions is insensitive to enhanced PD-L1 levels on CNS cells.Q42484597
Intracerebral infection with murine cytomegalovirus induces CXCL10 and is restricted by adoptive transfer of splenocytesQ47325477
Mouse resident microglia: isolation and characterization of immunoregulatory properties with naïve CD4+ and CD8+ T-cellsQ48501197
Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.Q48974951
Antigen presentation by astrocytes primes rat T lymphocytes for apoptotic cell death. A model for T-cell apoptosis in vivoQ49021926
Prolonged infection of mouse brain neurons with murine cytomegalovirus after pre- and perinatal infection.Q52212255
PD-L1 (B7-H1) regulation in zones of axonal degeneration.Q52923617
Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells comparedQ72169034
Astrocytes and central nervous system endothelial cells do not express B7-1 (CD80) or B7-2 (CD86) immunoreactivity during experimental autoimmune encephalomyelitisQ73056300
P433issue10
P921main subjectneurogliaQ177105
P304page(s)1582-1594
P577publication date2014-06-03
P1433published inGliaQ15716658
P1476titleGlial cells suppress postencephalitic CD8+ T lymphocytes through PD-L1.
P478volume62