Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions

scientific article

Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/ANIE.201105901
P698PubMed publication ID22095772

P50authorGisbert SchneiderQ51615601
Petra SchneiderQ110029671
P2093author name stringZoe Waibler
Stefanie Bauer
Jan A Hiss
Karl-Heinz Altmann
Bernhard Pfeiffer
Michael Reutlinger
Tim Geppert
Martin Weisel
Elea Conrad
P2860cites workThe Protein Data BankQ24515306
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The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solutionQ27748770
The overlap of small molecule and protein binding sites within families of protein structuresQ28472769
Inhibitors of Helicobacter pylori protease HtrA found by 'virtual ligand' screening combat bacterial invasion of epitheliaQ28477589
Ligand efficiency: a useful metric for lead selectionQ29617403
PocketPicker: analysis of ligand binding-sites with shape descriptors.Q30364721
Spatial chemical conservation of hot spot interactions in protein-protein complexesQ33302062
Small molecular weight protein-protein interaction antagonists: an insurmountable challenge?Q33337530
Fragment-Based Drug DesignQ33730346
The type I interferon receptor: structure, function, and evolution of a family business.Q33765617
Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2.Q33862977
ANCHOR: a web server and database for analysis of protein-protein interaction binding pockets for drug discoveryQ33957616
Autoimmune disease complicating antiviral therapy for hepatitis C virus infectionQ35045126
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Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and toleranceQ36426325
Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complexQ36458100
Targeting protein-protein interactions with small molecules: challenges and perspectives for computational binding epitope detection and ligand findingQ36611966
Type I interferon as a stimulus for cross-primingQ37027815
Endogenous type I interferon inducers in autoimmune diseasesQ37610432
Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and hostQ37721131
Structural biology in fragment-based drug designQ37752790
HotPoint: hot spot prediction server for protein interfacesQ38373749
Matrix protein mediated shutdown of host cell metabolism limits vesicular stomatitis virus-induced interferon-alpha responses to plasmacytoid dendritic cellsQ40034481
Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cellsQ42142515
Modified vaccinia virus Ankara induces Toll-like receptor-independent type I interferon responsesQ42910554
Molecular recognition of receptor sites using a genetic algorithm with a description of desolvationQ43987901
Context-based identification of protein-protein interfaces and "hot-spot" residues.Q51585524
Side-chain flexibility in proteins upon ligand binding.Q52080522
Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-α responses by pDCQ57339899
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectprotein-protein interactionQ896177
virtual screeningQ4112105
P304page(s)258-261
P577publication date2011-11-16
P1433published inAngewandte Chemie International EditionQ62023953
P1476titleImmunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions
P478volume51

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cites work (P2860)
Q50243911A metal-based inhibitor of tumor necrosis factor-α.
Q34331745Does chemistry have a future in therapeutic innovations?
Q58697064Evolution of In Silico Strategies for Protein-Protein Interaction Drug Discovery
Q35214824Hierarchical virtual screening approaches in small molecule drug discovery
Q34135430In silico identification of an interferon inhibitor
Q34481459Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions
Q27674529Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α
Q35738960State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors
Q35103944Structure-based design of small-molecule protein-protein interaction modulators: the story so far.

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