Capric acid inhibits NO production and STAT3 activation during LPS-induced osteoclastogenesis

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Capric acid inhibits NO production and STAT3 activation during LPS-induced osteoclastogenesis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...627739P
P356DOI10.1371/JOURNAL.PONE.0027739
P932PMC publication ID3218024
P698PubMed publication ID22110749
P5875ResearchGate publication ID51824288

P50authorEun-Jung ParkQ88848206
P2093author name stringSangdun Choi
Hyuk-Kwon Kwon
Gwang Lee
Sun A Kim
Yong-Min Choi
Wooyoung Shim
P2860cites workMCP-1-induced human osteoclast-like cells are tartrate-resistant acid phosphatase, NFATc1, and calcitonin receptor-positive but require receptor activator of NFkappaB ligand for bone resorptionQ81464707
Inhibitory effects of orally administrated liposomal bovine lactoferrin on the LPS-induced osteoclastogenesisQ84115705
STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteriaQ46082397
Modulation of osteoclastogenesis by fatty acidsQ46490345
A p38 mitogen-activated protein kinase inhibitor arrests active alveolar bone loss in a rat periodontitis modelQ46864205
Nitric oxide synthesis in endothelial cells: evidence for a pathway inducible by TNF-alpha.Q50800975
Decreased nitric oxide levels stimulate osteoclastogenesis and bone resorption both in vitro and in vivo on the chick chorioallantoic membrane in association with neoangiogenesis.Q51604397
Osteoporosis with increased osteoclastogenesis in hematopoietic cell-specific STAT3-deficient mice.Q52562535
Systemic bone loss and induction of coronary vessel disease in a rat model of chronic inflammation.Q53565120
Inhibition of Nitric Oxide Synthase Blocks Osteoclastic Bone Resorption in Adaptive Bone ModelingQ58145727
Low NO concentrations inhibit osteoclast formation in mouse marrow cultures by cGMP-dependent mechanismQ73191511
Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligandQ73211247
Ca2+ or phorbol ester but not inflammatory stimuli elevate inducible nitric oxide synthase messenger ribonucleic acid and nitric oxide (NO) release in avian osteoclasts: autocrine NO mediates Ca2+-inhibited bone resorptionQ73251559
Nitric oxide is a regulator of bone remodellingQ73718709
Essential fatty acids and osteoporosisQ73740493
Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)Q73907464
A p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone lossQ79240430
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandQ24653311
Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implicationsQ24806684
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteinsQ27860890
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTORQ28144113
Nitric oxide synthases: structure, function and inhibitionQ28207668
MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formationQ28236005
Functional interactions between Stat5 and the glucocorticoid receptorQ28294034
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systemsQ28294477
Nitric oxide and boneQ28343869
Osteoclast differentiation and activationQ29547556
The molecular basis of osteoclast differentiation and activationQ34201145
Jaks, STATs, Cytokines, and SepsisQ34987949
Inhibition of lipopolysaccharide‐inducible nitric oxide synthase, TNF‐α and COX‐2 expression by sauchinone effects on I‐κBα phosphorylation, C/EBP and AP‐1 activationQ35045262
Gene therapy targeting monocyte chemoattractant protein-1 for vascular diseaseQ35057480
Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorptionQ35174052
Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthaseQ35183474
Regulation of the expression of inducible nitric oxide synthase.Q35605774
Effects of interferon-gamma on nitric oxide synthase activity and endothelin-1 production by vascular endothelial cellsQ35821780
Modulation of osteoclast formationQ36032112
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthaseQ38311029
An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharideQ38349380
Interleukin-6 inhibits receptor activator of nuclear factor kappaB ligand-induced osteoclastogenesis by diverting cells into the macrophage lineage: key role of Serine727 phosphorylation of signal transducer and activator of transcription 3.Q39993181
Bacterial lipopolysaccharide induces osteoclast formation in RAW 264.7 macrophage cellsQ40114184
Molecular analysis of RANKL-independent cell fusion of osteoclast-like cells induced by TNF-alpha, lipopolysaccharide, or peptidoglycanQ40195873
Conjugated linoleic acid inhibits osteoclast differentiation of RAW264.7 cells by modulating RANKL signalingQ40279586
Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation.Q40809918
STATs: signal transducers and activators of transcriptionQ40974978
Differential use of CREB binding protein-coactivator complexesQ41064392
Regulation of expression of the human monocyte chemotactic protein-1 receptor (hCCR2) by cytokinesQ41120279
Osteoclast formation and activity in the pathogenesis of osteoporosis in rheumatoid arthritisQ44209334
Nitric oxide enhances osteoclastogenesis possibly by mediating cell fusionQ44341875
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e27739
P577publication date2011-11-16
P1433published inPLOS OneQ564954
P1476titleCapric acid inhibits NO production and STAT3 activation during LPS-induced osteoclastogenesis
P478volume6

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cites work (P2860)
Q34092086A medium-chain fatty acid, capric acid, inhibits RANKL-induced osteoclast differentiation via the suppression of NF-κB signaling and blocks cytoskeletal organization and survival in mature osteoclasts
Q21134602Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo
Q92354216Anti-osteoclastogenic effect of epigallocatechin gallate-functionalized gold nanoparticles in vitro and in vivo
Q35691436Canine mammary cancer cells direct macrophages toward an intermediate activation state between M1/M2.
Q92277418Diallyl disulfide alleviates inflammatory osteolysis by suppressing osteoclastogenesis via NF-κB-NFATc1 signal pathway
Q39304006Evidence for mitoxantrone-induced block of inwardly rectifying K(+) channels expressed in the osteoclast precursor RAW 264.7 cells differentiated with lipopolysaccharide
Q57074587Inflammatory mechanisms and oxidative stress in prostatitis: the possible role of antioxidant therapy
Q36543680Interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway is essential for macrophage infiltration and myoblast proliferation during muscle regeneration
Q50016514LC-MS-based serum metabolomics reveals a distinctive signature in patients with rheumatoid arthritis
Q40364616Mechanisms involved in enhancement of matrix metalloproteinase-9 expression in macrophages by interleukin-33.
Q92538377More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis
Q35548822Morphological and proteomic analyses reveal that unsaturated guluronate oligosaccharide modulates multiple functional pathways in murine macrophage RAW264.7 cells.
Q40309601Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways
Q34807106Photobiomodulation induced by 670 nm light ameliorates MOG35-55 induced EAE in female C57BL/6 mice: a role for remediation of nitrosative stress
Q91662693Therapeutic potentials and modulatory mechanisms of fatty acids in bone
Q42496287Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function.

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