Current status of pH-sensitive liposomes in drug delivery

scientific article

Current status of pH-sensitive liposomes in drug delivery is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0163-7827(00)00011-4
P698PubMed publication ID11082506

P2093author name stringLeroux J
Drummond DC
Zignani M
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Formation and intracellular transport of a heterodimeric viral spike protein complexQ27485688
The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolutionQ27730234
Interactions of serum proteins with small unilamellar liposomes composed of dioleoylphosphatidylethanolamine and oleic acid: high-density lipoprotein, apolipoprotein A1, and amphipathic peptides stabilize liposomesQ28329353
pH-sensitive, plasma-stable liposomes with relatively prolonged residence in circulationQ28334431
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Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levelsQ33600489
Surface aggregation and membrane penetration by peptides: relation to pore formation and fusionQ33637965
Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumorsQ33649082
Poly(ethylenimine) and its role in gene deliveryQ33698747
Solubilization and reconstitution of vesicular stomatitis virus envelope using octylglucosideQ33915275
Role of the N-terminal peptides of viral envelope proteins in membrane fusion.Q33933461
Biological barriers to cellular delivery of lipid-based DNA carriersQ33933468
Effect of cholesterol and charge on pore formation in bilayer vesicles by a pH-sensitive peptideQ34041314
Formation of virosomes from influenza subunits and liposomesQ34053696
Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cellsQ34151692
Orientation of the pore-forming peptide GALA in POPC vesicles determined by a BODIPY-avidin/biotin binding assayQ34170259
Fusion of phosphatidylethanolamine-containing liposomes and mechanism of the L alpha-HII phase transitionQ34189125
H+- and Ca2+-induced fusion and destabilization of liposomes.Q34199456
Viral and cellular membrane fusion proteinsQ34208540
Membrane fusion and molecular segregation in phospholipid vesiclesQ34220149
Polyamidoamine cascade polymers mediate efficient transfection of cells in cultureQ34347285
Measurement of endosome pH following folate receptor-mediated endocytosis.Q34388863
Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycolQ34433380
Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agentsQ34556950
Development of anti-p185HER2 immunoliposomes for cancer therapyQ34607767
Diphtheria toxin fragment forms large pores in phospholipid bilayer membranesQ35461718
Immunopotentiating reconstituted influenza virus virosome vaccine delivery system for immunization against hepatitis AQ35613832
Immunopotentiating reconstituted influenza virosomes (IRIVs) and other adjuvants for improved presentation of small antigensQ35624905
Phosphatidylethanolamine liposomes: drug delivery, gene transfer and immunodiagnostic applicationsQ35756732
Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporationQ35989488
Membrane fusion mutants of Semliki Forest virusQ36209563
Efficient cytoplasmic delivery of a fluorescent dye by pH-sensitive immunoliposomesQ36212534
pH-induced alterations in the fusogenic spike protein of Semliki Forest virusQ36214003
Anti-peptide antibodies detect steps in a protein conformational change: low-pH activation of the influenza virus hemagglutininQ36217109
Macrophages possess probenecid-inhibitable organic anion transporters that remove fluorescent dyes from the cytoplasmic matrixQ36217291
A view of acidic intracellular compartmentsQ36218662
A prelysosomal compartment sequesters membrane-impermeant fluorescent dyes from the cytoplasmic matrix of J774 macrophagesQ36219515
The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathwayQ36222686
pH-sensitive liposomes: acid-induced liposome fusionQ36255409
Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusionQ36281287
Structural and functional comparisons of pH-sensitive liposomes composed of phosphatidylethanolamine and three different diacylsuccinylglycerolsQ41730384
Endocytosis of liposomes by macrophages: binding, acidification and leakage of liposomes monitored by a new fluorescence assayQ41733888
Mechanisms of delivery of liposome-encapsulated cytosine arabinoside to CV-1 cells in vitro. Fluorescence-microscopic and cytotoxicity studiesQ41736738
Immunoliposomes with different acid sensitivities as probes for the cellular endocytic pathwayQ41758406
Reconstitution of the fusogenic activity of vesicular stomatitis virus.Q41827323
pH-sensitive liposomes mediate cytoplasmic delivery of encapsulated macromoleculesQ41918013
Effects of ammonium chloride and chloroquine on endocytic uptake of liposomes by Kupffer cells in vitroQ41919239
Endocytosis of liposomes and intracellular fate of encapsulated molecules: encounter with a low pH compartment after internalization in coated vesiclesQ41921571
Inhibition of Semliki forest virus penetration by lysosomotropic weak basesQ41923695
Acidic pH triggers LCMV membrane fusion activity and conformational change in the glycoprotein spikeQ41935856
Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cellsQ41942524
Lipid interaction of Pseudomonas aeruginosa exotoxin A. Acid-triggered permeabilization and aggregation of lipid vesiclesQ42036139
Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivoQ42042312
Specificity of amphiphilic anionic peptides for fusion of phospholipid vesiclesQ42184772
Small, but not large, unilamellar liposomes composed of dioleoylphosphatidylethanolamine and oleic acid can be stabilized by human plasmaQ42193508
Destabilization of phosphatidylethanolamine-containing liposomes: hexagonal phase and asymmetric membranesQ42219112
Biodistribution of pH-sensitive immunoliposomesQ42222822
Pharmacokinetic behavior of vincristine sulfate following administration of vincristine sulfate liposome injectionQ42674865
Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitroQ42746832
Conformation of membrane fusion-active 20-residue peptides with or without lipid bilayers. Implication of alpha-helix formation for membrane fusionQ43579771
Photolabeling identifies a putative fusion domain in the envelope glycoprotein of rabies and vesicular stomatitis virusesQ43631145
pH-dependent membrane fusion activity of a synthetic twenty amino acid peptide with the same sequence as that of the hydrophobic segment of influenza virus hemagglutininQ44047893
Immunogenicity and adverse effects of inactivated virosome versus alum-adsorbed hepatitis A vaccine: a randomized controlled trialQ44048281
Effect of lysolecithin on the structure and permeability of lecithin bilayer vesiclesQ44093181
Interaction of influenza hemagglutinin amino-terminal peptide with phospholipid vesicles: a fluorescence studyQ44111720
Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA.Q44282173
Application of membrane-active peptides for nonviral gene deliveryQ44320484
An improved method of loading pH-sensitive liposomes with soluble proteins for class I restricted antigen presentationQ44458932
Targeted delivery of hygromycin B using reconstituted Sendai viral envelopes lacking hemagglutinin-neuraminidaseQ44496637
Peptides and membrane fusion: towards an understanding of the molecular mechanism of protein-induced fusionQ44600727
pH sensitive liposomes provide an efficient means of sensitizing target cells to class I restricted CTL recognition of a soluble proteinQ44624457
Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly(ethylene glycol)-phospholipid conjugates for efficient in vivo gene deliveryQ45090289
Membrane Fusion by Peptide Analogues of Influenza Virus HaemagglutininQ45154024
Mutational analysis of the fusion peptide of the human immunodeficiency virus type 1: identification of critical glycine residues.Q45771113
Preparation, properties, and applications of reconstituted influenza virus envelopes (virosomes).Q45776156
Structure and topology of the influenza virus fusion peptide in lipid bilayersQ45790260
Virosomes constructed from lipid and purified Friend leukaemia virus glycoproteinQ45794133
Mouse mammary tumor virus can mediate cell fusion at reduced pHQ45796741
Glycoprotein micelles isolated from vesicular stomatitis virus spontaneously partition into sonicated phosphatidylcholine vesiclesQ45802698
Virosomes reconstituted from human immunodeficiency virus proteins and lipidsQ45849443
Membrane fusion activity of the influenza virus hemagglutinin: interaction of HA2 N-terminal peptides with phospholipid vesiclesQ45854072
Gene transfer mediated by fusion protein hemagglutinin reconstituted in cationic lipid vesiclesQ45862556
Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or pH-sensitive peptidesQ45864035
Enhanced folate receptor mediated gene therapy using a novel pH-sensitive lipid formulationQ45864705
Cationic liposome-mediated intravenous gene deliveryQ45866771
Cellular and Molecular Barriers to Gene Transfer by a Cationic LipidQ45868044
Pore-forming peptides induce rapid phospholipid flip-flop in membranes.Q46016360
The acid-triggered entry pathway of Pseudomonas exotoxin A.Q46067010
Systemic Gene Expression After Intravenous DNA Delivery into Adult MiceQ46128630
Efficiency of cytoplasmic delivery by pH-sensitive liposomes to cells in cultureQ46140381
Copolymers of N-isopropylacrylamide can trigger pH sensitivity to stable liposomesQ46169436
Association of a pH-sensitive peptide with membrane vesicles: role of amino acid sequenceQ46362467
Sterically stabilized pH-sensitive liposomes. Intracellular delivery of aqueous contents and prolonged circulation in vivoQ46380222
Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface-grafted poly(ethylene glycol).Q46391939
Membrane contact, fusion, and hexagonal (HII) transitions in phosphatidylethanolamine liposomesQ46543012
Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networksQ46601538
Interaction of diphtheria toxin with model membranesQ68342920
Tissue specific opsonins for phagocytic cells and their different affinity for cholesterol-rich liposomesQ68412199
Orientation into the lipid bilayer of an asymmetric amphipathic helical peptide located at the N-terminus of viral fusion proteinsQ68610948
31P- and 1H-NMR investigations of the effect of n-alcohols on the hydrolysis by phospholipase A2 of phospholipid vesicular membranesQ68640673
Low pH induced membrane fusion of lipid vesicles containing proton-sensitive polymerQ68686250
Effect of exogenous lysolecithin on liposomal membranes. Its relation to membrane fluidityQ68710167
Fate of protein-containing liposomes injected into rats. An approach to the treatment of storage diseasesQ68990458
Chimerasome-mediated gene transfer in vitro and in vivoQ69363191
pH-dependent stability and fusion of liposomes combining protonatable double-chain amphiphiles with phosphatidylethanolamineQ69394027
Light-induced fusion of liposomes with release of trapped marker dye is sensitised by photochromic phospholipidQ69417473
Large unilamellar liposomes with low uptake into the reticuloendothelial systemQ69422002
Novel preparation of functional Sindbis virosomesQ69613600
Polylysine induces pH-dependent fusion of acidic phospholipid vesicles: a model for polycation-induced fusionQ69613633
pH-dependent bilayer destabilization and fusion of phospholipidic large unilamellar vesicles induced by diphtheria toxin and its fragments A and BQ69647867
pH sensitization of phospholipid vesicles via complexation with synthetic poly(carboxylic acid)sQ69840851
Membrane fusionQ69915796
Role of cholesterol in membranes. Effects on phospholipid-protein interactions, membrane permeability and enzymatic activityQ70004463
Rotary dialysis: its application to the preparation of large liposomes and large proteoliposomes (protein-lipid vesicles) with high encapsulation efficiency and efficient reconstitution of membrane proteinsQ70099604
Conformational studies of amphipathic alpha-helical peptides containing an amino acid with a long alkyl chain and their anchoring to lipid bilayer liposomesQ70135123
beta-Galactosidase-induced destabilization of liposome composed of phosphatidylethanolamine and ganglioside GM1Q70383661
Role of lipid phase separations and membrane hydration in phospholipid vesicle fusionQ70423005
Stability of small unilamellar liposomes in serum and clearance from the circulation: the effect of the phospholipid and cholesterol componentsQ70434011
Effect of lipoprotein-free plasma on the interaction of human plasma high density lipoprotein with egg yolk phosphatidylcholine liposomesQ70652977
Leakage of the fluorescent Ca2+ indicator fura-2 in smooth muscleQ70683343
A study of phospholipid interactions between high-density lipoproteins and small unilamellar vesiclesQ70720803
Fusion activity of an amphiphilic polypeptide having acidic amino acid residues: generation of fusion activity by alpha-helix formation and charge neutralizationQ70779196
Virosomes as carriers for combined vaccinesQ70961248
Transfer and exchange of phospholipid between small unilamellar liposomes and rat plasma high density lipoproteins Dependence on cholesterol content and phospholipid compositionQ70968141
Influence of cholesterol on the association of plasma proteins with liposomesQ71028970
Poly(ethylene glycol)--lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserineQ71028995
Kinetics of membrane micellization by the hydrophobic polyelectrolyte poly(2-ethylacrylic acid)Q71029184
Control of membrane fusion by phospholipid head groups. II. The role of phosphatidylethanolamine in mixtures with phosphatidate and phosphatidylinositolQ71033529
Triggerable plasmalogen liposomes: improvement of system efficiencyQ71065353
Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfectionQ71099227
Cholesterol content of small unilamellar liposomes controls phospholipid loss to high density lipoproteins in the presence of serumQ71142092
Interaction of fusogenic synthetic peptide with phospholipid bilayers: orientation of the peptide alpha-helix and binding isothermQ71145605
Oxidation of sulfhydryl groups of ribonuclease inhibitor in epithelial cells is sufficient for its intracellular degradationQ71245530
pH-induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contactQ71348420
pH-sensitive liposomes: possible clinical implicationsQ71379883
Effect of liposomal composition on photoactivated liposome fusionQ71506669
Transmembrane gradient driven phase transitions within vesicles: lessons for drug deliveryQ71561923
On the relationship between the probenecid-sensitive transport of daunorubicin or calcein and the glutathione status of cells overexpressing the multidrug resistance-associated protein (MRP)Q71628024
Liposome longevity and stability in circulation: effects on the in vivo delivery to tumors and therapeutic efficacy of encapsulated anthracyclinesQ71674724
Polyamines. Biological modulators of membrane fusionQ71787213
Mechanism of liposome destabilization by polycationic amino acidsQ71788662
Liposome fusion and lipid exchange on ultraviolet irradiation of liposomes containing a photochromic phospholipidQ71966875
Interactions of liposome bilayers composed of 1,2-diacyl-3-succinylglycerol with protons and divalent cationsQ72031842
Novel pH-sensitive liposomes: liposomes bearing a poly(ethylene glycol) derivative with carboxyl groupsQ72076933
Synthesis and characterization of N-acylated, pH-sensitive ‘caged’ aminophospholipidsQ72112886
Characterization of putative polyphosphoinositide binding motifs from phospholipase C beta 2Q72143207
Interaction of the HIV-1 fusion peptide with phospholipid vesicles: different structural requirements for fusion and leakageQ72311722
Membrane interaction and conformational properties of the putative fusion peptide of PH-30, a protein active in sperm-egg fusionQ72371465
Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitroQ72567988
Design of a short membrane-destabilizing peptide covalently bound to liposomesQ72773899
Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak basesQ72927459
Polycation-induced fusion of negatively-charged vesiclesQ72956614
Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlationQ73034285
Acid-catalyzed plasmenylcholine hydrolysis and its effect on bilayer permeability: a quantitative studyQ73202077
pH-induced destabilization of lipid bilayers by a lipopeptide derived from influenza hemagglutininQ73202087
Preparation and characterization of pH-responsive polymeric micelles for the delivery of photosensitizing anticancer drugsQ73423000
In vitro characterization of a novel polymeric-based pH-sensitive liposome systemQ73450378
Interactions between poly(2-ethylacrylic acid) and lipid bilayer membranes: effects of cholesterol and grafted poly(ethylene glycol)Q73816862
Controlling liposome blood clearance by surface-grafted polymersQ73850384
Enhancement of the in vivo circulation lifetime of L-alpha-distearoylphosphatidylcholine liposomes: importance of liposomal aggregation versus complement opsonizationQ73883734
Poly(amidoamine)s as potential endosomolytic polymers: evaluation in vitro and body distribution in normal and tumour-bearing animalsQ74149975
Membrane fusion induced by 11-mer anionic and cationic peptides: a structure-function studyQ74252250
Temperature-dependent associating property of liposomes modified with a thermosensitive polymerQ74520358
Phase I study of liposomal vincristineQ74611898
Transfection of human macrophages by lipoplexes via the combined use of transferrin and pH-sensitive peptidesQ74628170
Triggerable liposomal fusion by enzyme cleavage of a novel peptide-lipid conjugateQ74746687
Comparison of different hydrophobic anchors conjugated to poly(ethylene glycol): effects on the pharmacokinetics of liposomal vincristineQ74801955
Adjuvant activity of immunopotentiating reconstituted influenza virosomes (IRIVs)Q77295244
Acid- and calcium-induced structural changes in phosphatidylethanolamine membranes stabilized by cholesteryl hemisuccinateQ93569078
Generation of pH-sensitive liposomes: use of large unilamellar vesicles containing N-succinyldioleoylphosphatidylethanolamineQ93669688
Site-specific gene delivery in vivo through engineered Sendai viral envelopesQ36324500
Tetanus toxin fragment forms channels in lipid vesicles at low pHQ36325692
pH-dependent perforation of macrophage phagosomes by listeriolysin O from Listeria monocytogenes.Q36380649
Rapid acidification of endocytic vesicles containing alpha 2-macroglobulinQ36590519
Preparation of influenza virosome vaccine with muramyldipeptide derivative B30-MDP.Q36841888
Cytoplasmic delivery of calcein mediated by liposomes modified with a pH-sensitive poly(ethylene glycol) derivativeQ36863146
Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cellsQ36947229
Characterization of the insertion of Pseudomonas exotoxin A into membranesQ37031247
High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.Q37093747
Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicleQ37171224
Adenovirus enhancement of transferrin-polylysine-mediated gene deliveryQ37603166
Antibody-targeted liposomes: increase in specific toxicity of methotrexate-gamma-aspartateQ37605346
Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacyQ37650345
Delivery to cancer cells of antisense L-myc oligonucleotides incorporated in fusogenic, cationic-lipid-reconstituted influenza-virus envelopes (cationic virosomes).Q38334893
Anti-HER2 immunoliposomes for targeted therapy of human tumors.Q38340086
Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers.Q38347812
Proton-induced fusion of oleic acid-phosphatidylethanolamine liposomesQ38590583
Catecholamine uptake and concentration by liposomes maintaining pH gradientsQ39121313
Use of reconstituted influenza virus virosomes as an immunopotentiating delivery system for a peptide-based vaccineQ39372910
Lipid intermolecular hydrogen bonding: influence on structural organization and membrane functionQ39668638
Lipid polymorphism and the functional roles of lipids in biological membranesQ39840976
Vesicular stomatitis virus glycoprotein mutations that affect membrane fusion activity and abolish virus infectivity.Q39869009
Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradientsQ40027855
A physicochemical approach for predicting the effectiveness of peptide-based gene delivery systems for use in plasmid-based gene therapyQ40121811
Membrane fusion proteins of enveloped animal virusesQ40164521
Disintegration of phosphatidylcholine liposomes in plasma as a result of interaction with high-density lipoproteinsQ40169960
Interaction between unilamellar egg yolk lecithin vesicles and human high density lipoproteinQ40208485
Amphiphilic peptides enhance the efficiency of liposome-mediated DNA transfectionQ40226407
Phase transitions and phase separations in phospholipid membranes induced by changes in temperature, pH, and concentration of bivalent cationsQ40303683
Preferred conformation and molecular packing of phosphatidylethanolamine and phosphatidylcholineQ40310846
The folate receptor works in tandem with a probenecid-sensitive carrier in MA104 cells in vitroQ40340486
Liposome-mediated cytoplasmic delivery of proteins: an effective means of accessing the MHC class I-restricted antigen presentation pathwayQ40568770
Cytosine arabinoside influx and nucleoside transport sites in acute leukemiaQ40684781
Stability of liposomal doxorubicin formulations: problems and prospectsQ40840462
Design of Liposomes for Enhanced Local Release of Drugs by HyperthermiaQ40872200
A chimeric fusion protein containing transforming growth factor-alpha mediates gene transfer via binding to the EGF receptorQ41036764
Cellular retention of liposome-delivered anionic compounds modulated by a probenecid-sensitive anion transporterQ41084509
Membrane destabilization by N-terminal peptides of viral envelope proteinsQ41085283
Non-bilayer lipids and biological fusion intermediatesQ41114315
Influence of membrane-active peptides on lipospermine/DNA complex mediated gene transfer.Q41123524
Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipidsQ41170129
Interaction of tetanus toxin with lipid vesicles. Effects of pH, surface charge, and transmembrane potential on the kinetics of channel formationQ41194770
Homodimeric Association of the Spike Glycoproteins G1 and G2 of Uukuniemi VirusQ41316923
Engineered liposomes and virosomes for delivery of macromoleculesQ41328034
Cellular cytoplasmic delivery of a polypeptide toxin by reconstituted influenza virus envelopes (virosomes).Q41449059
Immunoliposomes for Cancer TreatmentQ41526933
In vitro cytotoxicity of liposome-encapsulated doxorubicin: dependence on liposome composition and drug releaseQ41607838
Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesiclesQ41608176
Fusion activity of flaviviruses: comparison of mature and immature (prM-containing) tick-borne encephalitis virionsQ41682471
New detachable poly(ethylene glycol) conjugates: cysteine-cleavable lipopolymers regenerating natural phospholipid, diacyl phosphatidylethanolamineQ41692785
Thermosensitive sterically stabilized liposomes: formulation and in vitro studies on mechanism of doxorubicin release by bovine serum and human plasmaQ46763113
N-succinyldioleoylphosphatidylethanolamine: structural preferences in pure and mixed model membranesQ47591096
Evidence for the modulation of Pseudomonas aeruginosa exotoxin A-induced pore formation by membrane surface charge densityQ47650205
pH-dependent fusion of liposomes using titratable polycationsQ48552920
The fusion of artificial lipid membranes induced by the synthetic arenavirus 'fusion peptide'Q50240173
pH-dependent membrane fusion and vesiculation of phospholipid large unilamellar vesicles induced by amphiphilic anionic and cationic peptides.Q50795412
pH-dependent bilayer destabilization by an amphipathic peptide.Q50902539
The accumulation of drugs within large unilamellar vesicles exhibiting a proton gradient: a survey.Q51739405
The effect of surface charge on the hydrolysis kinetics of partially hydrogenated egg phosphatidylcholine and egg phosphatidylglycerol in aqueous liposome dispersions.Q52399110
Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand.Q52478451
Application of membrane-active peptides for drug and gene delivery across cellular membranes.Q52539463
Polyhistidine mediates an acid-dependent fusion of negatively charged liposomes.Q52688338
Phase transitions in phospholipid vesicles Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterolQ52938610
Aggregation and fusion of lipid vesicles induced by diphtheria toxin at low pH: possible involvement of the P site and the NAD+ binding site.Q53758098
Role of cholesterol in the stability of pH-sensitive, large unilamellar liposomes prepared by the detergent-dialysis method.Q54351564
Transfer of condensed viral DNA into eukaryotic cells using proteoliposomes.Q54386892
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomesQ56386325
Elastase activated liposomal delivery to nucleated cellsQ57188971
Poly(ethylene glycol)-lipid conjugates promote bilayer formation in mixtures of non-bilayer-forming lipidsQ57189551
Effects of lysophosphatidylcholines on phosphatidylcholine and phosphatidylcholine/cholesterol liposome systems as revealed by 31P-NMR, electron microscopy and permeability studiesQ57190655
Interactions of liposomes and hydrophobically-modified poly-(N-isopropylacrylamides): an attempt to model the cytoskeletonQ57355988
Temperature-controlled release property of phospholipid vesicles bearing a thermo-sensitive polymerQ57355991
Temperature-sensitive liposomes: liposomes bearing poly (N-isopropylacrylamide)Q57356621
Destabilization of cationic lipid vesicles by an anionic hydrophobically modified poly(N-isopropylacrylamide) copolymer: a solid-state 31P NMR and 2H NMR studyQ57357663
Modification of liposomes with N-substituted polyacrylamides: identification of proteins adsorbed from plasmaQ57357669
Contribution of Hydrogen Bonding to the Association of Liposomes and an Anionic Hydrophobically Modified Poly(N-isopropylacrylamide)†Q57361306
Synthesis and Characterization of a Hydrophobically Modified Copolymer ofN-Isopropylacrylamide and Glycinyl AcrylamideQ57362716
Temperature-Sensitivity of Liposomal Lipid Bilayers Mixed with Poly(N-Isopropylacrylamide-co-acrylic Acid)Q57369929
Enzyme replacement via liposomes variations in lipid composition determine liposomal integrity in biological fluidsQ57731319
Interactions of colicin A domains with phospholipid monolayers and liposomes relevance to the mechanism of actionQ58197694
Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pHQ59049627
Solution Properties of Poly(N-isopropylacrylamide)Q60670598
Targeting of Drugs to Solid Tumors Using Anti-Her2 ImmunoliposomesQ62101006
Targeting of Liposomes to Solid Tumors: The Case of Sterically Stabilized Anti-Her2 ImmunoliposomesQ62101032
Diphtheria toxin induces leakage of acidic liposomesQ62140008
A Polymer-Triton X-100 Conjugate Capable of PH-Dependent Red Blood Cell Lysis: A Model System Illustrating the Possibility of Drug Delivery Within Acidic Intracellular CompartmentsQ63413797
Poly(amidoamine)s with potential as drug carriers: degradation and cellular toxicityQ63413812
Effects of membrane-active agents in gene deliveryQ64381942
Stability of liposomes invivo and invitro is promoted by their cholesterol content and the presence of blood cellsQ66954982
Interaction between oleic acid-containing pH-sensitive and plain liposomes. Fluorescent spectroscopy studiesQ67480772
Membrane fusionQ67584890
Triggered release of hydrophilic agents from plasmalogen liposomes using visible light or acidQ68017325
Versatility in lipid compositions showing prolonged circulation with sterically stabilized liposomesQ68126326
Some negatively charged phospholipid derivatives prolong the liposome circulation in vivoQ68222160
P433issue5
P921main subjectdrug deliveryQ1392806
P304page(s)409-460
P577publication date2000-09-01
P1433published inProgress in Lipid ResearchQ15757018
P1476titleCurrent status of pH-sensitive liposomes in drug delivery
P478volume39

Reverse relations

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Q35916173Endosomal escape and transfection efficiency of PEGylated cationic liposome-DNA complexes prepared with an acid-labile PEG-lipid.
Q45856593Enhanced protein internalization and efficient endosomal escape using polyampholyte-modified liposomes and freeze concentration
Q37520625Enhanced transfection efficiency of a systemically delivered tumor-targeting immunolipoplex by inclusion of a pH-sensitive histidylated oligolysine peptide
Q37799614Enzyme-triggered nanomedicine: drug release strategies in cancer therapy.
Q36555626Exploring the role of polymer structure on intracellular nucleic acid delivery via polymeric nanoparticles.
Q48168207Far infrared spectroscopy of hydrogen bonding collective motions in complex molecular systems.
Q36077599Formation of droplet networks that function in aqueous environments
Q57838410Formation, stability, and pH sensitivity of free-floating, giant unilamellar vesicles using palmitic acid–cholesterol mixtures
Q44709519Fourier transformed spectral bio-imaging for studying the intracellular fate of liposomes
Q37166374Functional lipids and lipoplexes for improved gene delivery.
Q38396298Functional liposomes in the cancer-targeted drug delivery.
Q41239588Glucosomes: Glycosylated Vesicle-in-Vesicle Aggregates in Water from pH-Responsive Microbial Glycolipid
Q35899936Hydrodynamic interactions of deformable polymeric nanocarriers and the effect of crosslinking
Q37167336Imaging characteristics of zinc sulfide shell, cadmium telluride core quantum dots
Q46629942Improved preparation of PEG-diortho ester-diacyl glycerol conjugates
Q30665894In situ formation of magnetopolymersomes via electroporation for MRI.
Q38004708In vivo gene delivery by nonviral vectors: overcoming hurdles?
Q36247075Influence of polymer size, liposomal composition, surface charge, and temperature on the permeability of pH-sensitive liposomes containing lipid-anchored poly(2-ethylacrylic acid).
Q46477273Interaction of pH-sensitive non-phospholipid liposomes with cellular mimetic membranes.
Q41629194Interactions between pH-sensitive liposomes and model membranes
Q40650255Intracellular delivery of ceramide lipids via liposomes enhances apoptosis in vitro
Q35157616Ligand-targeted liposomal anticancer drugs
Q36062119Lipid based particulate formulations for the delivery of antigen.
Q52725104Lipid-Based Particles: Versatile Delivery Systems for Mucosal Vaccination against Infection.
Q37670986Lipid-based nanotherapeutics for siRNA delivery
Q37668583Liposomal Nanoparticles Carrying anti-IL6R Antibody to the Tumour Microenvironment Inhibit Metastasis in Two Molecular Subtypes of Breast Cancer Mouse Models
Q37679954Liposomal cancer therapy: exploiting tumor characteristics
Q38806793Liposomal drug delivery systems for targeted cancer therapy: is active targeting the best choice?
Q42705145Liposome technology for industrial purposes
Q35595419Liposome-based approaches to overcome anticancer drug resistance
Q36554124Liposomes as targeted drug delivery systems in the treatment of breast cancer
Q93956736Literature alerts
Q92145740Loading and Releasing Ciprofloxacin in Photoactivatable Liposomes
Q38049024Mathematical modeling of vesicle drug delivery systems 1: vesicle formation and stability along with drug loading and release
Q92940334Mechanical Stability of Lipid Membranes Decorated with Dextran Sulfate
Q34180623Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid
Q50935948Mechanisms of Light-induced Liposome Permeabilization.
Q39388041Mesostructured chitosan-silica hybrid as a biodegradable carrier for a pH-responsive drug delivery system
Q64238127Modification of fliposomes with a polycation can enhance the control of pH-induced release
Q35116121Molecular-genetic imaging of cancer
Q36969145Multifunctional nanoparticulate polyelectrolyte complexes
Q37508725Nanocarriers' entry into the cell: relevance to drug delivery
Q36942446Nanogel-Conjugated Reverse Transcriptase Inhibitors and Their Combinations as Novel Antiviral Agents with Increased Efficacy against HIV-1 Infection
Q37426991Nanotechnology for delivery of drugs to the brain for epilepsy
Q37058812Nanovehicular intracellular delivery systems
Q85173990New pH-sensitive liposomes containing phosphatidylethanolamine and a bacterial dirhamnolipid
Q34003800Next generation delivery system for proteins and genes of therapeutic purpose: why and how?
Q28080632Nonenzymatic Reactions above Phospholipid Surfaces of Biological Membranes: Reactivity of Phospholipids and Their Oxidation Derivatives
Q40509566Novel cationic lipids incorporating an acid-sensitive acylhydrazone linker: synthesis and transfection properties
Q50497275One-step synthesis of small-sized and water-soluble NaREF4 upconversion nanoparticles for in vitro cell imaging and drug delivery.
Q38020769Particulate systems for targeting of macrophages: basic and therapeutic concepts.
Q36908719Pharmacokinetic, biodistribution and therapeutic efficacy of 5-fluorouracil-loaded pH-sensitive PEGylated liposomal nanoparticles in HCT-116 tumor bearing mouse
Q39043619Plasma stable, pH-sensitive fusogenic polymer-modified liposomes: A promising carrier for mitoxantrone.
Q39058091Plasma stable, pH-sensitive non-ionic surfactant vesicles simultaneously enhance antiproliferative effect and selectivity of Sirolimus
Q57378079Polyacrylic Acid Modifies Local and Lateral Mobilities in Lipid Membranes
Q40710913Polymer based pH-sensitive carriers as a means to improve the cytoplasmic delivery of drugs
Q64972321Preparation and Characterization of Electrostatically Crosslinked Polymer⁻Liposomes in Anticancer Therapy.
Q36442116Preparation and characterization of stable pH-sensitive vesicles composed of α-tocopherol hemisuccinate
Q42767195Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
Q37805491Properties, engineering and applications of lipid-based nanoparticle drug-delivery systems: current research and advances
Q43260853Quantitative high-performance thin-layer chromatography determination of common liposome components and critical parameters influencing the analysis results
Q33765349RODENT STROKE MODEL GUIDELINES FOR PRECLINICAL STROKE TRIALS (1ST EDITION).
Q36001035Rapid Light-Triggered Drug Release in Liposomes Containing Small Amounts of Unsaturated and Porphyrin-Phospholipids
Q34006151Rattle-type hollow CaWO4:Tb(3+)@SiO2 nanocapsules as carriers for drug delivery
Q36293288Recent advances in non-viral gene delivery
Q37197375Recent progress in tumor pH targeting nanotechnology
Q30456053Recent trends in multifunctional liposomal nanocarriers for enhanced tumor targeting
Q42939121Recombinant Immunotoxin Therapy of Solid Tumors: Challenges and Strategies
Q36771350Release mechanisms for polyelectrolyte capsules
Q44031108Self-assembled hydrogel nanoparticles responsive to tumor extracellular pH from pullulan derivative/sulfonamide conjugate: characterization, aggregation, and adriamycin release in vitro
Q80149584Sterically stabilized ph-sensitive liposomes
Q50060960Stimulus-responsive liposomes as smart nanoplatforms for drug delivery applications
Q38182668Strategies for drug delivery to the central nervous system by systemic route
Q38116638Strategies for triggered drug release from tumor targeted liposomes
Q58742505Strategies to Encapsulate the Bacteriophage phiIPLA-RODI
Q36988355Surface-active liposomes for targeted cancer therapy
Q35193987Synthesis and characterization of lipid-polymer hybrid nanoparticles with pH-triggered poly(ethylene glycol) shedding.
Q39263297TRAIL-NP hybrids for cancer therapy: a review.
Q51749858Targeted paclitaxel delivery to tumors using cleavable PEG-conjugated solid lipid nanoparticles.
Q37930418Targeting ischemic penumbra Part II: selective drug delivery using liposome technologies
Q43026319Temperature-controlled supramolecular vesicles modulated by p-sulfonatocalix[5]arene with pyrene.
Q39640316Templating synthesis of preloaded Doxorubicin in hollow mesoporous silica nanospheres for biomedical applications.
Q45280310Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers
Q37848296Topical and mucosal liposomes for vaccine delivery.
Q37972351Trigger release liposome systems: local and remote controlled delivery?
Q44133672Triggered release of doxorubicin following mixing of cationic and anionic liposomes
Q73124685Tumor-cell targeted epiderimal growth factor liposomes loaded with boronated acridine: uptake and processing
Q36293302What role can chemistry play in cationic liposome-based gene therapy research today?
Q39499046pDNA-lipoplexes engrafted with flagellin-related peptide induce potent immunity and anti-tumour effects
Q38794157pH sensitive coiled coils: a strategy for enhanced liposomal drug delivery
Q42953897pH-Triggered Release from Nonphospholipid LUVs Modulated by the pKa of the Included Fatty Acid
Q57363827pH-responsive mitoxantrone (MX) delivery using mesoporous silica nanoparticles (MSN)
Q38136240pH-sensitive liposomes for drug delivery in cancer treatment.
Q44650970pH-sensitive liposomes in nuclear targeting of macromolecules
Q36790100pH-sensitive liposomes--principle and application in cancer therapy
Q43774578pH-sensitive nanoparticles of poly(amino acid) dodecanoate complexes
Q41629181pH-sensitive paramagnetic liposomes for MRI: assessment of stability in blood
Q54724915γ-Amino acid mutated α-coiled coils as mild thermal triggers for liposome delivery.

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