A mitochondrial DNA clone is associated with increased risk for Alzheimer disease

scientific article

A mitochondrial DNA clone is associated with increased risk for Alzheimer disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1995PNAS...92.6892H
P356DOI10.1073/PNAS.92.15.6892
P932PMC publication ID41436
P698PubMed publication ID7624338
P5875ResearchGate publication ID15575485

P2093author name stringG Cortopassi
T Hutchin
P2860cites workAfrican Populations and the Evolution of Human Mitochondrial DNAQ22065576
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer diseaseQ22248076
Leber hereditary optic neuropathy: identification of the same mitochondrial ND1 mutation in six pedigreesQ24678456
The neighbor-joining method: a new method for reconstructing phylogenetic treesQ25939010
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset familiesQ27860677
Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14Q28156208
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseQ28241772
Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathyQ28292821
Construction of phylogenetic treesQ29547497
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's diseaseQ29614952
Alzheimer's disease and senile dementia: loss of neurons in the basal forebrainQ34714755
A molecular basis for human hypersensitivity to aminoglycoside antibioticsQ35000709
Epidemiology of Alzheimer's DiseaseQ35188935
Multiple etiologies for Alzheimer disease are revealed by segregation analysis.Q35889556
Branching pattern in the evolutionary tree for human mitochondrial DNA.Q37410666
Familial Alzheimer's disease: progress and problemsQ38715582
NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH–ubiquinone reductase preparationQ39273179
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondriaQ41829151
NADH- and NADPH-dependent lipid peroxidation in bovine heart submitochondrial particles. Dependence on the rate of electron flow in the respiratory chain and an antioxidant role of ubiquinolQ41986067
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.Q43597292
Is the prevalence of dementia changing?Q44490404
Prevalence of Alzheimer's disease in a retirement communityQ44854737
Mitochondrial ribosomal RNA mutation associated with both antibiotic–induced and non–syndromic deafnessQ46157086
Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported.Q52112673
Mitochondrial respiratory chain inhibitors induce apoptosis.Q52544710
Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3Q53178836
A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene.Q53178841
Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients.Q53206553
Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham StudyQ53295392
Linkage of late-onset Alzheimer's disease with apolipoprotein E type 4 on chromosome 19.Q53316369
Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvementQ67724128
1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particlesQ68474033
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
mitochondrial DNAQ27075
P304page(s)6892-6895
P577publication date1995-07-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleA mitochondrial DNA clone is associated with increased risk for Alzheimer disease
P478volume92

Reverse relations

cites work (P2860)
Q51737097A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease.
Q34211127A mitochondrial etiology of Alzheimer and Parkinson disease
Q29547303A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
Q38469487A new approach to the genetic analysis of nervous system diseases: retrospective genotyping of archival brains.
Q34144436A novel homoplasmic mutation in mtDNA with a single evolutionary origin as a risk factor for cardiomyopathy
Q48458709A unifying hypothesis of Alzheimer's disease. III. Risk factors
Q36986848Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication
Q34725635Amyloid-Beta interaction with mitochondria
Q28396290Analysis of mitochondrial DNA variations in Indian patients with congenital cataract
Q36833616Ancient mtDNA sequences in the human nuclear genome: a potential source of errors in identifying pathogenic mutations
Q35510313Bioenergetic origins of complexity and disease
Q24533221Classification of European mtDNAs from an analysis of three European populations
Q92939847Codon optimization is an essential parameter for the efficient allotopic expression of mtDNA genes
Q36573774Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases
Q53232811Effect of aluminium-induced Alzheimer like condition on oxidative energy metabolism in rat liver, brain and heart mitochondria.
Q45107551Elevated levels of the Kearns-Sayre syndrome mitochondrial DNA deletion in temporal cortex of Alzheimer's patients
Q35131161Endonuclease III and endonuclease VIII conditionally targeted into mitochondria enhance mitochondrial DNA repair and cell survival following oxidative stress
Q50509552Enhanced mitochondrial DNA repair and cellular survival after oxidative stress by targeting the human 8-oxoguanine glycosylase repair enzyme to mitochondria
Q44452930Evidence for adaptive selection acting on the tRNA and rRNA genes of human mitochondrial DNA.
Q21136190Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease
Q34477829Expression profiles of mitochondrial genes in the frontal cortex and the caudate nucleus of developing humans and mice selectively bred for high and low fear
Q37172134Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease
Q33588353Genetic risk factors in Alzheimer's disease
Q34187826Human mitochondrial genetics
Q57624017Identification of Novel Genes in Late-Onset Alzheimer's Disease
Q33253241Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics
Q78241746Isolation and microinjection of somatic cell-derived mitochondria and germline heteroplasmy in transmitochondrial mice
Q28192185Laboratory approach to mitochondrial diseases
Q35881405Longitudinal study of a heteroplasmic 3460 Leber hereditary optic neuropathy family by multiplexed primer-extension analysis and nucleotide sequencing
Q47976401Mito-GSAAC: mitochondria prediction using genetic ensemble classifier and split amino acid composition
Q35898628Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer's disease
Q38932850Mitochondria, Cybrids, Aging, and Alzheimer's Disease
Q33698535Mitochondrial DNA analysis: polymorphisms and pathogenicity
Q58136336Mitochondrial DNA and Disease
Q33364885Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease
Q34214032Mitochondrial DNA in aging and degenerative disease
Q36855295Mitochondrial DNA polymorphisms in pathologically proven Parkinson's disease
Q33889143Mitochondrial DNA repair and association with aging--an update
Q36649957Mitochondrial DNA repair: a critical player in the response of cells of the CNS to genotoxic insults
Q33603868Mitochondrial DNA sequence associations with dementia and amyloid-β in elderly African Americans
Q34140769Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly
Q53238571Mitochondrial DNA variants in inclusion body myositis.
Q36223869Mitochondrial DNA, base excision repair and neurodegeneration
Q33780440Mitochondrial biogenesis dysfunction and metabolic dysfunction from a novel mitochondrial tRNAMet 4467 C>A mutation in a Han Chinese family with maternally inherited hypertension
Q28280353Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease
Q41547386Mitochondrial dysfunction in neurodegeneration
Q35557675Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease
Q36000745Mitochondrial failures in Alzheimer's disease
Q58105767Mitochondrial genetic medicine
Q33540918Mitochondrial involvement in Alzheimer's disease
Q36045522Mitochondrial mutations and polymorphisms in psychiatric disorders
Q35689426Mitochondrial ribosomal proteins: candidate genes for mitochondrial disease
Q41757587Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease.
Q33969627Multiple origins of a mitochondrial mutation conferring deafness.
Q39729622Nitric oxide-induced damage to mtDNA and its subsequent repair
Q38263132No evidence of association between common European mitochondrial DNA variants in Alzheimer, Parkinson, and migraine in the Spanish population
Q50864482No mitochondrial haplotype was found to increase risk for Alzheimer's disease.
Q77905916Phylogenetic analysis of the mitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population
Q47358251Prediction of mitochondrial proteins using support vector machine and hidden Markov model.
Q41725491Recent developments in the molecular genetics of mitochondrial disorders
Q24563892Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups
Q33932655Role of SCOX in determination of Drosophila melanogaster lifespan
Q35016920Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease
Q41748125Some remarks on biological markers of Alzheimer's disease
Q34246990Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia
Q46774788Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from 2-methoxyestradiol-induced-mitochondria-dependent apoptosis
Q37656554The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives
Q36235630The Role of Mitochondrial Non-Enzymatic Protein Acylation in Ageing
Q35080485The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific
Q34416941The other, forgotten genome: mitochondrial DNA and mental disorders
Q35174458The role of mitochondria in the life of the nematode, Caenorhabditis elegans
Q33678113The tRNA(Gln) 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before the age of 75 years.
Q28077056Triad of Risk for Late Onset Alzheimer's: Mitochondrial Haplotype, APOE Genotype and Chromosomal Sex
Q48482729mtDNA polymorphisms in Japanese sporadic Alzheimer's disease

Search more.