| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2011PLoSO...627851A |
| P356 | DOI | 10.1371/JOURNAL.PONE.0027851 |
| P932 | PMC publication ID | 3225372 |
| P698 | PubMed publication ID | 22140473 |
| P5875 | ResearchGate publication ID | 51852599 |
| P50 | author | Ashley S Doane | Q56996411 |
| Hikmat Al-Ahmadie | Q42862200 | ||
| P2093 | author name string | William Gerald | |
| Kenneth Leslie | |||
| Qing Chang | |||
| Agnes Viale | |||
| David Lyden | |||
| Jacqueline Bromberg | |||
| Janeen Azare | |||
| Jennifer Nnoli | |||
| Marjan Berishaj | |||
| Kevin Mark | |||
| Mary Stracke | |||
| Maryam Hassimi | |||
| P2860 | cites work | Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein | Q24299154 |
| cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases | Q24309264 | ||
| Tumor self-seeding by circulating cancer cells | Q24658224 | ||
| IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland | Q24669531 | ||
| Global cancer statistics, 2002 | Q27860562 | ||
| Tumour invasion and metastasis initiated by microRNA-10b in breast cancer | Q28131829 | ||
| The emerging role of lysophosphatidic acid in cancer | Q28191543 | ||
| Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma | Q28208041 | ||
| Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis | Q28208182 | ||
| Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor | Q28216396 | ||
| Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells | Q28218904 | ||
| Expression, regulation and function of autotaxin in thyroid carcinomas | Q28251014 | ||
| Autotaxin is an exoenzyme possessing 5'-nucleotide phosphodiesterase/ATP pyrophosphatase and ATPase activities | Q28301252 | ||
| Genes that mediate breast cancer metastasis to lung | Q29547479 | ||
| Mesenchymal stem cells within tumour stroma promote breast cancer metastasis | Q29614303 | ||
| A multigenic program mediating breast cancer metastasis to bone | Q29614308 | ||
| Circulating tumor cells, disease progression, and survival in metastatic breast cancer | Q29619276 | ||
| Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts | Q30436718 | ||
| Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets | Q33212086 | ||
| Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors | Q33565565 | ||
| The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors | Q33613105 | ||
| Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression. | Q33740488 | ||
| Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases | Q34148745 | ||
| The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin | Q34476721 | ||
| Stat proteins and oncogenesis | Q34627064 | ||
| Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation | Q34989115 | ||
| Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. | Q52572763 | ||
| Repression of E-cadherin by SNAIL, ZEB1, and TWIST in invasive ductal carcinomas of the breast: a cooperative effort?☆ | Q60221834 | ||
| Expression of autotaxin mRNA in human hepatocellular carcinoma | Q74604992 | ||
| Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity | Q81752994 | ||
| The role of autotaxin and other motility stimulating factors in the regulation of tumor cell motility | Q41585651 | ||
| Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis | Q42679964 | ||
| Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity. | Q42819611 | ||
| Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. | Q42833476 | ||
| Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells | Q43649346 | ||
| A pooled analysis of bone marrow micrometastasis in breast cancer | Q44594123 | ||
| Microarray analysis identifies Autotaxin, a tumour cell motility and angiogenic factor with lysophospholipase D activity, as a specific target of cell transformation by v-Jun. | Q44703503 | ||
| Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers | Q44706680 | ||
| Mammary tumorigenesis through LPA receptor signaling. | Q45992125 | ||
| Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization | Q46822898 | ||
| Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression | Q46882515 | ||
| Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades | Q47855910 | ||
| Autotaxin, tumor motility-stimulating exophosphodiesterase | Q48055332 | ||
| Stat3 Controls Cell Movements during Zebrafish Gastrulation | Q48315175 | ||
| Dissecting the metastatic cascade | Q35788115 | ||
| Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB | Q35812229 | ||
| Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6 | Q35857048 | ||
| Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer. | Q35906313 | ||
| Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts | Q36080795 | ||
| Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance | Q36092560 | ||
| Exploring a new twist on tumor metastasis | Q36465194 | ||
| Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function | Q36662693 | ||
| Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells | Q36742070 | ||
| Regulation and biological activities of the autotaxin-LPA axis. | Q36801833 | ||
| Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression | Q36945006 | ||
| Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. | Q36986233 | ||
| Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis | Q37088041 | ||
| Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis | Q37119757 | ||
| Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis | Q37486563 | ||
| Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis | Q38290076 | ||
| Is autotaxin (ENPP2) the link between hepatitis C and hepatocellular cancer? | Q38297778 | ||
| Evaluation of potential Stat3-regulated genes in human breast cancer | Q38322580 | ||
| Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors | Q38324882 | ||
| Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells | Q38326221 | ||
| Stat3 regulates genes common to both wound healing and cancer | Q38329956 | ||
| Reciprocal effects of STAT5 and STAT3 in breast cancer | Q38353556 | ||
| Signal transducer and activator of transcription 3 upregulates interleukin-8 expression at the level of transcription in human melanoma cells. | Q39798930 | ||
| Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. | Q39828317 | ||
| MDA-MB-435 and M14 cell lines: identical but not M14 melanoma? | Q39834203 | ||
| Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. | Q39975221 | ||
| Concordant correlation of LIV-1 and E-cadherin expression in human breast cancer cell MCF-7. | Q40004151 | ||
| Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line | Q40071039 | ||
| Amino acid residues required for physical and cooperative transcriptional interaction of STAT3 and AP-1 proteins c-Jun and c-Fos | Q40106192 | ||
| MDA-MB-435 cells are derived from M14 melanoma cells--a loss for breast cancer, but a boon for melanoma research | Q40227151 | ||
| Identifying site-specific metastasis genes and functions. | Q40251368 | ||
| Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid | Q40289797 | ||
| Identification of large-scale molecular changes of Autotaxin(ENPP2) knock-down by small interfering RNA in breast cancer cells | Q40294655 | ||
| Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation | Q40298486 | ||
| Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein | Q40302630 | ||
| Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. | Q40309855 | ||
| An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen | Q40313659 | ||
| Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells | Q40333333 | ||
| Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice | Q40439895 | ||
| Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy | Q40508006 | ||
| Lineage infidelity of MDA-MB-435 cells: expression of melanocyte proteins in a breast cancer cell line | Q40554428 | ||
| Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer | Q40558625 | ||
| Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. | Q40577570 | ||
| Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells | Q40739267 | ||
| Autotaxin expression in non-small-cell lung cancer | Q40939277 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | e27851 | |
| P577 | publication date | 2011-11-28 | |
| P1433 | published in | PLOS One | Q564954 |
| P1476 | title | Stat3 mediates expression of autotaxin in breast cancer | |
| P478 | volume | 6 |
| Q47710637 | Aberrant lipid metabolism in cancer cells - the role of oncolipid-activated signaling |
| Q47866372 | Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3. |
| Q45920167 | An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis. |
| Q37702227 | Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy |
| Q55420502 | Autotaxin in Pathophysiology and Pulmonary Fibrosis. |
| Q57818887 | Autotaxin upregulated by STAT3 activation contributes to invasion in pancreatic neuroendocrine neoplasms |
| Q48126105 | Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity |
| Q37042617 | Combination treatment with flavonoid morin and telomerase inhibitor MST‑312 reduces cancer stem cell traits by targeting STAT3 and telomerase |
| Q35080781 | Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells |
| Q35733734 | Constitutive phosphorylated STAT3-associated gene signature is predictive for trastuzumab resistance in primary HER2-positive breast cancer |
| Q34916123 | Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling. |
| Q95267139 | Dihydroartemisinin Prevents Progression and Metastasis of Head and Neck Squamous Cell Carcinoma by Inhibiting Polarization of Macrophages in Tumor Microenvironment |
| Q92703023 | Energy Metabolism in Cancer: The Roles of STAT3 and STAT5 in the Regulation of Metabolism-Related Genes |
| Q28482954 | Exocrine pancreatic carcinogenesis and autotaxin expression |
| Q92909892 | Expression of proteins related to autotaxin-lysophosphatidate signaling in thyroid tumors |
| Q55446160 | GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling. |
| Q42323384 | Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies |
| Q42209269 | Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro. |
| Q38614760 | Interleukin 6 induces M2 macrophage differentiation by STAT3 activation that correlates with gastric cancer progression |
| Q38878851 | JAK-STAT signaling in cancer: From cytokines to non-coding genome. |
| Q36343400 | Multiple regulation pathways and pivotal biological functions of STAT3 in cancer. |
| Q35754295 | Persistent activation of STAT3 by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer |
| Q35894524 | Prognostic value of protein inhibitor of activated STAT3 in breast cancer patients receiving hormone therapy. |
| Q36677847 | Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells |
| Q38742218 | Stat3 modulates chloride channel accessory protein expression in normal and neoplastic mammary tissue |
| Q49449555 | TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration |
| Q90613341 | Targeting Angiogenesis in Pancreatic Neuroendocrine Tumors: Resistance Mechanisms |
| Q26825658 | Targeting the tumor microenvironment: JAK-STAT3 signaling |
| Q36945956 | The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis |
| Q38246634 | The role and therapeutic potential of the autotaxin-lysophosphatidate signalling axis in breast cancer |
| Q35000231 | Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma |
| Q47328912 | p-STAT3 in luminal breast cancer: Integrated RNA-protein pooled analysis and results from the BIG 2-98 phase III trial. |
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