Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy

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Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/CIRCRESAHA.110.221481
P932PMC publication ID2930621
P698PubMed publication ID20595652
P5875ResearchGate publication ID44902147

P2093author name stringJie Zhang
Silvia G Priori
Nian Liu
Guoxin Kang
Glenn I Fishman
Fang-Yu Liu
Steven F Giovannone
P2860cites workFlecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humansQ24608179
Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cellsQ24653592
Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardiaQ28201561
A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from IsraelQ28204838
Disruption of calcium homeostasis and arrhythmogenesis induced by mutations in the cardiac ryanodine receptor and calsequestrinQ28257514
RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR)Q28278038
Catecholaminergic polymorphic ventricular tachycardiaQ28287523
Arrhythmogenic mechanisms in a mouse model of catecholaminergic polymorphic ventricular tachycardiaQ28595062
Ca(2+) transients and Ca(2+) waves in purkinje cells : role in action potential initiationQ30843462
Mapping and ablation of ventricular fibrillation associated with long-QT and Brugada syndromesQ33149255
Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor.Q33152686
Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardiaQ33551271
Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass.Q33618629
Diastolic intracellular calcium-membrane voltage coupling gain and postshock arrhythmias: role of purkinje fibers and triggered activity.Q33639479
Reduced intercellular coupling leads to paradoxical propagation across the Purkinje-ventricular junction and aberrant myocardial activation.Q33932684
Immunocytochemical analysis of connexin expression in the healthy and diseased cardiovascular systemQ34141781
Contactin-2 expression in the cardiac Purkinje fiber networkQ34747800
Induction and patterning of the cardiac conduction system.Q34969544
Calcium overload and cardiac functionQ35865477
Toward an understanding of the genetics of murine cardiac pacemaking and conduction system development.Q35887928
Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.Q37393446
Catecholaminergic polymorphic ventricular tachycardia: A paradigm to understand mechanisms of arrhythmias associated to impaired Ca(2+) regulationQ37625277
Enhanced basal activity of a cardiac Ca2+ release channel (ryanodine receptor) mutant associated with ventricular tachycardia and sudden deathQ40711729
Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.Q43191839
Role of left ventricular scar and Purkinje-like potentials during mapping and ablation of ventricular fibrillation in dilated cardiomyopathyQ46094843
Verapamil-sensitive left anterior fascicular ventricular tachycardia associated with a healed myocardial infarction: changes in the delayed Purkinje potential during sinus rhythmQ46502397
Unexpected structural and functional consequences of the R33Q homozygous mutation in cardiac calsequestrin: a complex arrhythmogenic cascade in a knock in mouse modelQ46516049
Architectural and functional asymmetry of the His-Purkinje system of the murine heart.Q47352047
Reduced calcium currents in subendocardial Purkinje myocytes that survive in the 24- and 48-hour infarcted heartQ48108255
Reduced inward rectifying and increased E-4031-sensitive K+ current density in arrhythmogenic subendocardial purkinje myocytes from the infarcted heartQ48485470
Reducing ryanodine receptor open probability as a means to abolish spontaneous Ca2+ release and increase Ca2+ transient amplitude in adult ventricular myocytes.Q48708332
Interrelationships Between Automaticity and Conduction in Purkinje FibersQ51204643
T-tubule profiles in Purkinje fibres of mammalian myocardium.Q51983091
Electrotonic suppression of early afterdepolarizations in isolated rabbit Purkinje myocytes.Q54044181
Electrophysiology and ultrastructure of canine subendocardial Purkinje cells isolated from control and 24-hour infarcted heartsQ69747792
Transient Outward Currents in Subendocardial Purkinje Myocytes Surviving in the Infarcted HeartQ71955998
Effects of mibefradil, a T-type calcium current antagonist, on electrophysiology of Purkinje fibers that survived in the infarcted canine heartQ73074377
Ionic remodeling of cardiac Purkinje cells by congestive heart failureQ74843560
Role of Purkinje conducting system in triggering of idiopathic ventricular fibrillationQ77731640
Comparison of ion-channel subunit expression in canine cardiac Purkinje fibers and ventricular muscleQ78460665
Role of Purkinje fibers in post-infarction ventricular tachycardiaQ79437836
Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse modelQ79851890
Novel mechanism of postinfarction ventricular tachycardia originating in surviving left posterior Purkinje fibersQ80022321
Role of subendocardial Purkinje network in triggering torsade de pointes arrhythmia in experimental long QT syndromeQ81896618
Variations in the functional electrical coupling between the subendocardial Purkinje and ventricular layers of the canine left ventricleQ93594367
P433issue4
P921main subjectPurkinje cellQ1570272
P304page(s)512-519
P577publication date2010-07-01
P1433published inCirculation ResearchQ2599020
P1476titlePurkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy
P478volume107

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cites work (P2860)
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