Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice

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Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JOCA.2014.06.033
P932PMC publication ID4150746
P698PubMed publication ID25008209
P5875ResearchGate publication ID263815969

P50authorAngela CaiQ86455067
William E. SonntagQ56980500
P2093author name stringA Singh
H Matsumoto
R E Anderson
Y Kawashima
J Hudson
N Komori
T M Griffin
E Hutchison
R S Brush
P2860cites workGPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effectsQ24630455
The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseasesQ28276397
Biomechanical signals suppress TAK1 activation to inhibit NF-kappaB transcriptional activation in fibrochondrocytesQ28578466
Femur EPA and DHA are correlated with femur biomechanical strength in young fat-1 mice.Q33360673
Polyunsaturated fatty acids and inflammatory processes: New twists in an old taleQ33448682
Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphyQ33565653
Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritisQ33691146
Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritisQ33729300
Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund's Adjuvant-induced knee arthritisQ33765435
The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the guinea pigQ34168273
Identification of a central role for complement in osteoarthritisQ34230334
Regulation of osteoarthritis by omega-3 (n-3) polyunsaturated fatty acids in a naturally occurring model of diseaseQ35223640
Resolvins and protectins in inflammation resolution.Q35332873
High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injuryQ35907775
Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammationQ35999712
The role of synovitis in osteoarthritis pathogenesisQ36024641
Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine modelQ36198434
Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST studyQ36318320
Aging processes and the development of osteoarthritisQ37019846
The opposing effects of n-3 and n-6 fatty acidsQ37058217
High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degenerationQ37151815
Dietary fatty acid intake affects the risk of developing bone marrow lesions in healthy middle-aged adults without clinical knee osteoarthritis: a prospective cohort studyQ37270750
The relationship between longitudinal serum leptin measures and measures of magnetic resonance imaging-assessed knee joint damage in a population of mid-life women.Q37446504
Inflammation in osteoarthritisQ37608903
Post-traumatic osteoarthritis: improved understanding and opportunities for early interventionQ37869050
Inflammation and lipid signaling in the etiology of insulin resistanceQ38007632
Mouse models of osteoarthritis: modelling risk factors and assessing outcomes.Q38198901
Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice.Q39384907
Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritisQ39784181
Ligands for retinoic acid receptors are elevated in osteoarthritis and may contribute to pathologic processes in the osteoarthritic jointQ39845547
Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acidQ40069286
Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation.Q41897050
The growing array of innate inflammatory ignition switches in osteoarthritisQ43091252
Osteoarthritis induction leads to early and temporal subchondral plate porosity in the tibial plateau of mice: an in vivo microfocal computed tomography study.Q43713332
Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized miceQ44509153
Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.Q46122084
Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compressionQ46546640
Effect of fish oil on bone mineral density in aging C57BL/6 female mice.Q51786952
Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.Q53848758
Identification of molecular markers for articular cartilageQ54406376
Effect of fatty acids on bone marrow lesions and knee cartilage in healthy, middle-aged subjects without clinical knee osteoarthritisQ57265719
Fat-1 mice convert n-6 to n-3 fatty acidsQ59062098
n-3 Fatty acids are positively associated with peak bone mineral density and bone accrual in healthy men: the NO2 StudyQ79896849
Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in miceQ82240120
Endogenously produced n-3 fatty acids protect against ovariectomy induced bone loss in fat-1 transgenic miceQ84067042
P433issue9
P921main subjectknee osteoarthritisQ1777118
fatty acidQ61476
osteoarthritisQ62736
P304page(s)1301-1309
P577publication date2014-07-04
P1433published inOsteoarthritis and CartilageQ7107605
P1476titleMetabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice
P478volume22

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cites work (P2860)
Q42319037Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis
Q35146980Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis
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Q26771893Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria
Q50921433Profibrotic Infrapatellar Fat Pad Remodeling Without M1 Macrophage Polarization Precedes Knee Osteoarthritis in Mice With Diet-Induced Obesity.
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Q36247299Sunflower Oil but Not Fish Oil Resembles Positive Effects of Virgin Olive Oil on Aged Pancreas after Life-Long Coenzyme Q Addition
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Q91967629Transgenic conversion of ω-6 to ω-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis

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