A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies (scientific article)

Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody

Q33707416

Competition--a common motif for the imprinting mechanism?

Q33887777

Characterization of the RNA content of chromatin

Q33940935

Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming.

Q34037100

Chromosomal silencing and localization are mediated by different domains of Xist RNA.

Q34108304

The proliferating role of insulin and insulin-like growth factors in cancer

Q34172625

X chromosome inactivation is mediated by Xist RNA stabilization

Q34439255

Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum

Q34599474

In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin

Q34606712

Insulin-like growth factor system and sporadic malignant melanoma.

Q34756364

The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus

Q34776140

Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II.

Q34918219

The emerging role of RNA in the regulation of gene transcription in human cells

Q35089611

The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA.

Q35098579

Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation.

Q35120698

Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming

Q35130964

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

Q35208383

Regulation of insulin preRNA splicing by glucose

Q36130429

Two distinct mechanisms of silencing by the KvDMR1 imprinting control region

Q36392021

Imprinting of the mouse Igf2r gene depends on an intronic CpG island.

Q52184971

Imprinted expression of the Igf2r gene depends on an intronic CpG island.

Q52192434

Phase I study of the anti insulin-like growth factor 1 receptor (IGF-1R) monoclonal antibody, AVE1642, as single agent and in combination with bortezomib in patients with relapsed multiple myeloma

Q62016691

α-Amanitin: A specific inhibitor of one of two DNA-dependent RNA polymerase activities from calf thymus

Q69901208

Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin

Q69917178

The insulin-like growth factor 1 receptor gene is normally biallelically expressed in human juvenile tissue and tumours

Q72250018

Human insulin-like growth factor type I and type II receptors are not imprinted

Q72250045

Insulin-like growth factor I is a dual effector of multiple myeloma cell growth

Q73053018

Increased expression of insulin-like growth factor i is associated with Ara-C resistance in leukemia

Q79734958

Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing

Q85652146

A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele

Q36710170

Long noncoding RNAs: cellular address codes in development and disease

Q36837377

The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility

Q36931989

Higher order chromatin structure at the X-inactivation center via looping DNA.

Q36936154

CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop

Q36959918

Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts

Q37158599

The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor

Q37215171

Genomic imprinting: employing and avoiding epigenetic processes

Q37362832

Expression of insulin receptor isoform A and insulin-like growth factor-1 receptor in human acute myelogenous leukemia: effect of the dual-receptor inhibitor BMS-536924 in vitro

Q37389178

Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus.

Q37441308

Targeting the insulin-like growth factor network in cancer therapy

Q37839580

Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer

Q37859024

No-nonsense functions for long noncoding RNAs

Q37865710

Blockade of insulin-like growth factor type-1 receptor with cixutumumab (IMC-A12): a novel approach to treatment for multiple cancers

Q37903356

Plasma and tissue insulin-like growth factor-I receptor (IGF-IR) as a prognostic marker for prostate cancer and anti-IGF-IR agents as novel therapeutic strategy for refractory cases: a review

Q37904188

Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy

Q37975246

The insulin and insulin-like growth factor receptor family in neoplasia: an update

Q37984217

Targeting insulin-like growth factor in breast cancer therapeutics

Q37994382

The role of the insulin-like growth factor-I receptor in malignancy: an update

Q38055534

Structure and function of long noncoding RNAs in epigenetic regulation

Q38086776

Epigenetic reprogramming reverses the malignant epigenotype of the MMP/TIMP axis genes in tumor cells

Q39084351

Transcriptional silencing by hairpin RNAs complementary to a gene promoter

Q39330560

Inducible packaging cells for large-scale production of lentiviral vectors in serum-free suspension culture

Q40027528

Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway

Q40117414

Gametic imprinting in mammals

Q40383353

Epigenetic regulation of the taxol resistance-associated gene TRAG-3 in human tumors

Q40560633

Lack of reciprocal genomic imprinting of sense and antisense RNA of mouse insulin-like growth factor II receptor in the central nervous system

Q41645080

Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops

Q42632085

Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs

Q42677869

Survival of acute myeloid leukemia cells requires PI3 kinase activation

Q44408364

PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

Q45259661

Differential biallelic activation of three insulin-like growth factor II promoters in the mouse central nervous system.

Q45962552

Promoter-specific modulation of insulin-like growth factor II genomic imprinting by inhibitors of DNA methylation.

Q45985336

Tissue-specific imprinting of the mouse insulin-like growth factor II receptor gene correlates with differential allele-specific DNA methylation

Q46044781

Allele-specific histone acetylation accompanies genomic imprinting of the insulin-like growth factor II receptor gene

Q46986615

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal.

Q48125063

A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencer

Q48262708

P275

Creative Commons Attribution 4.0 International

copyrighted

issue

language of work or name

English

Q1860

P304

page(s)

9588-9601

P577

publication date

2014-08-04

P1433

published in

Nucleic Acids Research

Q135122

P1476

title

A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies

P478

volume

Reverse relations

cites work (P2860)

Q36774935	A long non-coding RNA interacts with Gfra1 and maintains survival of mouse spermatogonial stem cells
Q60045651	A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1
Q36375083	A novel long noncoding RNA IRAIN regulates cell proliferation in non small cell lung cancer
Q94526828	Aberrant LncRNA Expression in Leukemia
Q99630180	Aberrant allelic-switch of antisense lncRNA IRAIN may be an early diagnostic marker in laryngeal cancer
Q35846233	Antitumor potential of a synthetic interferon-alpha/PLGF-2 positive charge peptide hybrid molecule in pancreatic cancer cells
Q33798311	CRISPR Cas9-guided chromatin immunoprecipitation identifies miR483 as an epigenetic modulator of IGF2 imprinting in tumors
Q26772020	Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity
Q26749533	Clinical significance of microRNAs in chronic and acute human leukemia
Q59125184	Combined RNA-seq and RAT-seq mapping of long noncoding RNAs in pluripotent reprogramming
Q38649121	Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes
Q37231371	DNA Methylation Profiling of Uniparental Disomy Subjects Provides a Map of Parental Epigenetic Bias in the Human Genome
Q48469386	DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition.
Q47599561	Downregulation of LncRNA-RP11-317J10.2 promotes cell proliferation and invasion and predicts poor prognosis in colorectal cancer
Q92435023	Emerging role of long non-coding RNAs in normal and malignant hematopoiesis
Q55017665	Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors.
Q36853857	Epigenetic suppression of the antitumor cytotoxicity of NK cells by histone deacetylase inhibitor valproic acid
Q55365672	Expression levels of long non-coding RNAs are prognostic for AML outcome.
Q53190281	Genome-wide characterization of lncRNAs in acute myeloid leukemia.
Q92424009	Genome-wide interaction target profiling reveals a novel Peblr20-eRNA activation pathway to control stem cell pluripotency
Q92709550	High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination
Q38860033	Histone deacetylase inhibitor valproic acid promotes the induction of pluripotency in mouse fibroblasts by suppressing reprogramming-induced senescence stress
Q92318158	Identification of a novel long non-coding RNA within RUNX1 intron 5
Q38363814	Imprinted genes in myeloid lineage commitment in normal and malignant hematopoiesis
Q35818520	Inhibition of HIV-1 Viral Infection by an Engineered CRISPR Csy4 RNA Endoribonuclease
Q33776671	Knockdown of COPS3 Inhibits Lung Cancer Tumor Growth in Nude Mice by Blocking Cell Cycle Progression
Q98943915	LINC00649 underexpression is an adverse prognostic marker in acute myeloid leukemia
Q64275121	Long Non-Coding RNA and Acute Leukemia
Q38450930	Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia
Q64922153	Long non-coding RNAs in hematopoietic regulation.
Q28070169	Long non-coding RNAs in normal and malignant hematopoiesis
Q91585001	Long noncoding RNA IRAIN acts as tumor suppressor via miR-125b in multiple myeloma
Q90566209	Long noncoding RNAs and their epigenetic function in hematological diseases
Q46191604	Long noncoding RNAs in hematopoietic malignancies
Q28077492	Long noncoding RNAs: pivotal regulators in acute myeloid leukemia
Q37588289	Loss of insulin-like growth factor II imprinting is a hallmark associated with enhanced chemo/radiotherapy resistance in cancer stem cells
Q55034610	Lost in translation: The 3'-UTR of IGF1R as an ancient long noncoding RNA.
Q38434466	Microarray profiling and co-expression network analysis of the lncRNAs and mRNAs associated with acute leukemia in adults.
Q33581843	Mitochondrial DNA Hypomethylation Is a Biomarker Associated with Induced Senescence in Human Fetal Heart Mesenchymal Stem Cells.
Q58573068	Molecular Moirai: Long Noncoding RNA Mediators of HSC Fate
Q92051398	Non-Coding RNAs in IGF-1R Signaling Regulation: The Underlying Pathophysiological Link between Diabetes and Cancer
Q97519235	Novel Approaches to Profile Functional Long Noncoding RNAs Associated with Stem Cell Pluripotency
Q47098649	Novel insights into chromosomal conformations in cancer.
Q89705407	Oplr16 serves as a novel chromatin factor to control stem cell fate by modulating pluripotency-specific chromosomal looping and TET2-mediated DNA demethylation
Q94601237	Osblr8 orchestrates intrachromosomal loop structure required for maintaining stem cell pluripotency
Q64929300	Overexpression of ZEB2-AS1 lncRNA is associated with poor clinical outcomes in acute myeloid leukemia.
Q58752176	Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions
Q38732979	Perspectives of long non-coding RNAs in cancer
Q93188516	Profiling the epigenetic interplay of lncRNA RUNXOR and oncogenic RUNX1 in breast cancer cells by gene in situ cis-activation
Q91966794	Profiling the long noncoding RNA interaction network in the regulatory elements of target genes by chromatin in situ reverse transcription sequencing
Q38832417	Restoration of IGF2 imprinting by polycomb repressive complex 2 docking factor SUZ12 in colon cancer cells
Q64284722	Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia
Q90274839	Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance
Q55438295	Targeting the IGF1R Pathway in Breast Cancer Using Antisense lncRNA-Mediated Promoter cis Competition.
Q92137481	The Regulatory Roles of Long Noncoding RNAs in Acute Myeloid Leukemia
Q97072562	The role of Long Non-Coding RNAs (lncRNAs) and downstream signaling pathways in Leukemia progression
Q90170774	Three-dimensional genome: developmental technologies and applications in precision medicine
Q37616010	Understanding of leukemic stem cells and their clinical implications.
Q38815636	Valproic Acid Enhances iPSC Induction From Human Bone Marrow-Derived Cells Through the Suppression of Reprogramming-Induced Senescence
Q89143778	lncRNA TNXA-PS1 Modulates Schwann Cells by Functioning As a Competing Endogenous RNA Following Nerve Injury