An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration

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An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1016434087
P356DOI10.1038/NCB3026
P932PMC publication ID4150836
P698PubMed publication ID25150978
P5875ResearchGate publication ID264990287

P50authorMatthew L KutysQ58879875
P2093author name stringKenneth M Yamada
P2860cites workIntegrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.Q24292286
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturationQ24297812
FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodellingQ24297925
Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edgeQ24299723
PAK kinases are directly coupled to the PIX family of nucleotide exchange factorsQ24313368
Matrix crosslinking forces tumor progression by enhancing integrin signalingQ24646370
At the leading edge of three-dimensional cell migrationQ26823247
ECM-modulated cellular dynamics as a driving force for tissue morphogenesisQ26830415
Matrix elasticity directs stem cell lineage specificationQ27860761
Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathwayQ28201752
Basic fibroblast growth factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathwayQ28209505
GEFs and GAPs: critical elements in the control of small G proteinsQ28304540
Random versus directionally persistent cell migrationQ29616686
Cell migration: Rho GTPases lead the wayQ29616711
Integrin function: molecular hierarchies of cytoskeletal and signaling moleculesQ29618843
Plasticity of cell migration: a multiscale tuning modelQ29620332
Identification of phosphorylation sites in betaPIX and PAK1Q30370259
Integrins in cell migrationQ30417364
Collagen reorganization at the tumor-stromal interface facilitates local invasionQ30478870
The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently.Q30529262
Cadherins and Pak1 control contact inhibition of proliferation by Pak1-betaPIX-GIT complex-dependent regulation of cell-matrix signaling.Q33769261
Collagen density promotes mammary tumor initiation and progressionQ33845553
The extracellular matrix at a glanceQ34152843
Regulation of Rho family GTPases by cell-cell and cell-matrix adhesion.Q34988689
Development of an optimized backbone of FRET biosensors for kinases and GTPasesQ35579824
ROCK1-directed basement membrane positioning coordinates epithelial tissue polarityQ35624852
Nonpolarized signaling reveals two distinct modes of 3D cell migrationQ35925311
A Rac switch regulates random versus directionally persistent cell migrationQ36320639
Activity of Rho-family GTPases during cell division as visualized with FRET-based probesQ36323206
Dimensions in cell migration.Q37135420
Regulation of cell adhesion and migration by cell-derived matricesQ37191171
Rho protein crosstalk: another social network?Q37933751
Endothelin 1 induces beta 1Pix translocation and Cdc42 activation via protein kinase A-dependent pathway.Q40498665
Biosensors for characterizing the dynamics of rho family GTPases in living cellsQ41177591
Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migrationQ42448806
Coordination of Rho and Rac GTPase function via p190B RhoGAP.Q42723117
Analysis of activated GAPs and GEFs in cell lysatesQ42805250
A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.Q42823002
Beta1PIX, the PAK-interacting exchange factor, requires localization via a coiled-coil region to promote microvillus-like structures and membrane rufflesQ42823150
Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways.Q53673562
P433issue9
P921main subjectextracellular matrixQ193825
P304page(s)909-917
P577publication date2014-08-24
P1433published inNature Cell BiologyQ1574111
P1476titleAn extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration
P478volume16

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cites work (P2860)
Q26801184A Review of Cell Adhesion Studies for Biomedical and Biological Applications.
Q27305490Actin remodeling by Nck regulates endothelial lumen formation
Q26766248Cell polarity signaling in the plasticity of cancer cell invasiveness
Q33563348Contact guidance requires spatial control of leading-edge protrusion.
Q47386263EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration
Q91869885Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration
Q36236775Fibroblasts Lead the Way: A Unified View of 3D Cell Motility
Q90009199Fluorescence techniques in developmental biology
Q38840911Forces and mechanotransduction in 3D vascular biology.
Q51439316Functionalization, preparation and use of cell-laden gelatin methacryloyl-based hydrogels as modular tissue culture platforms.
Q37388516High-resolution Time-lapse Imaging and Automated Analysis of Microtubule Dynamics in Living Human Umbilical Vein Endothelial Cells
Q38737031Integrinβ1 modulates tumour resistance to gemcitabine and serves as an independent prognostic factor in pancreatic adenocarcinomas
Q37036429Lamellipodia are crucial for haptotactic sensing and response
Q35140517Measurement systems for cell adhesive forces.
Q28081571Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses
Q26777449Mechanosensing via cell-matrix adhesions in 3D microenvironments
Q46816570Mesenchymal Cell Invasion Requires Cooperative Regulation of Persistent Microtubule Growth by SLAIN2 and CLASP1.
Q47447885Mind the (sr)GAP - roles of Slit-Robo GAPs in neurons, brains and beyond.
Q38839147Minireview: Role of genetic changes of faciogenital dysplasia protein 1 in human disease
Q39183594Modular regulation of Rho family GTPases in development.
Q38715903Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts
Q27309249P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces
Q30360988PTP1B triggers integrin-mediated repression of myosin activity and modulates cell contractility.
Q47379112Regulated recruitment of SRGAP1 modulates RhoA signaling for contractility during epithelial junction maturation.
Q38865226Regulating Rho GTPases and their regulators
Q36147879Rho GEFs and GAPs: emerging integrators of extracellular matrix signaling
Q47301194Rho GTPase signaling complexes in cell migration and invasion
Q26781332Rho GTPase signalling in cell migration
Q58561130RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer
Q47221572SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis.
Q28834278Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics
Q27310361Statistical analysis of cell migration in 3D using the anisotropic persistent random walk model
Q90591291Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions
Q42098072Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1.
Q36171291Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen
Q50789406[Effects of RhoA silencing on proliferation of tongue squamous cancer cells].
Q30607901β-Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryo
Q103028451β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo

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