A hypervariable N-terminal region of Yersinia LcrV determines Toll-like receptor 2-mediated IL-10 induction and mouse virulence

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A hypervariable N-terminal region of Yersinia LcrV determines Toll-like receptor 2-mediated IL-10 induction and mouse virulence is …
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scholarly articleQ13442814

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P819ADS bibcode2005PNAS..10216049S
P356DOI10.1073/PNAS.0504728102
P932PMC publication ID1276055
P698PubMed publication ID16239347
P5875ResearchGate publication ID7527854

P50authorKaisa GranforsQ115858631
Andreas RoggenkampQ121133297
P2093author name stringJürgen Heesemann
Andreas Sing
Jim Hill
Dagmar Reithmeier-Rost
P2860cites workContribution of toll-like receptors 2 and 4 in an oral Yersinia enterocolitica mouse infection modelQ41464404
The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocationQ41482701
An antigen determining virulence in Pasteurella pestisQ41571363
Dissecting the structure of LcrV from Yersinia pestis, a truly unique virulence protein.Q47964555
LcrG-LcrV interaction is required for control of Yops secretion in Yersinia pestisQ24548891
Yersinia enterocolitica: the charisma continuesQ24683715
The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plagueQ27643133
Triggering the ExoS regulon of Pseudomonas aeruginosa: A GFP-reporter analysis of exoenzyme (Exo) S, ExoT and ExoU synthesisQ28492583
A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxRQ29615324
Development of rRNA-targeted PCR and in situ hybridization with fluorescently labelled oligonucleotides for detection of Yersinia speciesQ32038831
Antibody against V antigen prevents Yop-dependent growth of Yersinia pestisQ33716043
The tranquilizing injection of Yersinia proteins: a pathogen's strategy to resist host defenseQ33737241
LcrV plague vaccine with altered immunomodulatory propertiesQ33946882
Passive immunity to yersiniae mediated by anti-recombinant V antigen and protein A-V antigen fusion peptideQ34539663
The Yersinia Ysc-Yop 'type III' weaponryQ34931776
Interleukin-10 and inhibition of innate immunity to Yersiniae: roles of Yops and LcrV (V antigen)Q35159314
Active immunization with recombinant V antigen from Yersinia pestis protects mice against plagueQ35426559
Passive immunity to infection with Yersinia spp. mediated by anti-recombinant V antigen is dependent on polymorphism of V antigenQ35534751
Resistance to lipopolysaccharide mediated by the Yersinia pestis V antigen-polyhistidine fusion peptide: amplification of interleukin-10.Q35545012
Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunizationQ35557573
Evidence for two evolutionary lineages of highly pathogenic Yersinia speciesQ35583978
The Yersinia high-pathogenicity island (HPI): evolutionary and functional aspectsQ35922674
The Yersinia pestis V antigen is a regulatory protein necessary for Ca2(+)-dependent growth and maximal expression of low-Ca2+ response virulence genesQ36144953
Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppressionQ36371199
Substitution of two histidine residues in YadA protein of Yersinia enterocolitica abrogates collagen binding, cell adherence and mouse virulenceQ38294501
Transfer of the core region genes of the Yersinia enterocolitica WA-C serotype O:8 high-pathogenicity island to Y. enterocolitica MRS40, a strain with low levels of pathogenicity, confers a yersiniabactin biosynthesis phenotype and enhanced mouse viQ39654619
Differential contribution of Yersinia enterocolitica virulence factors to evasion of microbicidal action of neutrophils.Q39824291
Interaction of Yersinia enterocolitica with macrophages leads to macrophage cell death through apoptosisQ39831554
Immunochemical analysis of plasmid-encoded proteins released by enteropathogenic Yersinia sp. grown in calcium-deficient mediaQ40161831
Double immunofluorescence microscopic technique for accurate differentiation of extracellularly and intracellularly located bacteria in cell culture.Q40203819
Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient miceQ40756138
Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranesQ41458033
Yersinia V antigen induces both TLR homo- and heterotolerance in an IL-10-involving mannerQ41458250
P433issue44
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
P304page(s)16049-16054
P577publication date2005-10-20
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleA hypervariable N-terminal region of Yersinia LcrV determines Toll-like receptor 2-mediated IL-10 induction and mouse virulence
P478volume102