CD8(+)-T-cell immunity against Toxoplasma gondii can be induced but not maintained in mice lacking conventional CD4(+) T cells

scientific article

CD8(+)-T-cell immunity against Toxoplasma gondii can be induced but not maintained in mice lacking conventional CD4(+) T cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.70.2.434-443.2002
P932PMC publication ID127655
P698PubMed publication ID11796568

P2093author name stringImtiaz A Khan
Kenneth H Ely
Lori Casciotti
Martha E Williams
P2860cites workCD8+ T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cellsQ44000881
IFN-gamma and CD8+ T cells restore host defenses against Pneumocystis carinii in mice depleted of CD4+ T cellsQ44825785
Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.Q46315215
Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondiiQ48464908
Expression of intracellular IFN-gamma in HSV-1-specific CD8+ T cells identifies distinct responding subpopulations during the primary response to infection.Q52025483
IL-15 augments CD8+ T cell-mediated immunity against Toxoplasma gondii infection in mice.Q52046728
TCR alpha beta+ CD4- CD8- T cells differentiate extrathymically in an lck-independent manner and participate in early response against Listeria monocytogenes infection through interferon-gamma production.Q52193069
Murine CD8+ cytotoxic T lymphocytes lyse Toxoplasma gondii-infected cells.Q54283162
CD8+ T cells are the major lymphocyte subpopulation involved in the protective immune response to Toxoplasma gondii in mice.Q54297083
Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivoQ59054431
Kinetics and Regulation of NK Activity by Interleukin-2 and Interferon in Acute ToxoplasmosisQ67703866
Dual regulation of resistance against Toxoplasma gondii infection by Lyt-2+ and Lyt-1+, L3T4+ T cells in miceQ68093960
CD4+ alpha beta T cell and gamma delta T cell responses to Mycobacterium tuberculosis. Similarities and differences in Ag recognition, cytotoxic effector function, and cytokine productionQ72467836
Antigen-specific CD8+ T cell clone protects against acute Toxoplasma gondii infection in miceQ72670278
IL-15 prolongs the duration of CD8+ T cell-mediated immunity in mice infected with a vaccine strain of Toxoplasma gondiiQ73050590
Measurement of the efficacy of vaccines and antimicrobial therapy against infection with Toxoplasma gondiiQ73515059
Augmentation of the CD8+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infectionQ77399380
IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferationQ77658417
The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogensQ28198712
IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii modelQ33867200
Serodiagnosis of recently acquired Toxoplasma gondii infection with a recombinant antigenQ33974763
Lack of CD4(+) T cells does not affect induction of CD8(+) T-cell immunity against Encephalitozoon cuniculi infectionQ34004978
Requirement of non-T cells that produce gamma interferon for prevention of reactivation of Toxoplasma gondii infection in the brainQ34007181
IL-2 knockout recipient mice reject islet cell allograftsQ34299248
Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alphaQ34529654
Community study of toxoplasma antibodies in urban and rural schoolchildren aged 4 to 18 yearsQ35257302
Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosisQ35406362
Interleukin-12 enhances murine survival against acute toxoplasmosisQ35778829
Toxoplasmic encephalitis in AIDS.Q35810946
Toxoplasmosis in immunoglobulin M-suppressed mice.Q36336142
Emergence of NK1.1+ cells as effectors of IFN-gamma dependent immunity to Toxoplasma gondii in MHC class I-deficient miceQ36362549
A role for CD4+ NK1.1+ T lymphocytes as major histocompatibility complex class II independent helper cells in the generation of CD8+ effector function against intracellular infectionQ36366985
Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondiiQ36367127
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infectionQ36637922
Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.Q36641930
SCID mouse models of acute and relapsing chronic Toxoplasma gondii infectionsQ36950623
Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction.Q37178327
Constructing polycompetitor cDNAs for quantitative PCR.Q38315767
CD8+ T-cell interactions with Toxoplasma gondii: implications for processing of antigen for class-I-restricted recognition.Q40708644
Induction and regulation of host cell-mediated immunity by Toxoplasma gondiiQ41047837
From naive to memory T cellsQ41091863
Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccineQ41133376
Studies in listeriosis show the strong symbiosis between the innate cellular system and the T-cell responseQ41603380
The role of gammadelta T cells in induction of bacterial antigen-specific protective CD8+ cytotoxic T cells in immune response against the intracellular bacteria Listeria monocytogenesQ43426354
Helper T cells without CD4: control of leishmaniasis in CD4-deficient miceQ43806211
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectToxoplasma gondiiQ131003
P304page(s)434-443
P577publication date2002-02-01
P1433published inInfection and ImmunityQ6029193
P1476titleCD8(+)-T-cell immunity against Toxoplasma gondii can be induced but not maintained in mice lacking conventional CD4(+) T cells
P478volume70

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cites work (P2860)
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