Frameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract

scientific article

Frameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/IAI.00386-10
P932PMC publication ID2937465
P698PubMed publication ID20547745

P2093author name stringHarlan D Caldwell
Morgan M Goheen
Craig Martens
Laszlo Kari
Norma Olivares-Zavaleta
William M Whitmire
Donald J Gardner
Gail L Sturdevant
John H Carlson
Linnell B Randall
Elizabeth M Selleck
P2860cites workIFN-gamma-inducible Irga6 mediates host resistance against Chlamydia trachomatis via autophagyQ21562514
Comparative Genomic Analysis of Chlamydia trachomatis Oculotropic and Genitotropic StrainsQ22065493
Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatisQ22065557
Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39.Q22065998
The Chlamydia trachomatis plasmid is a transcriptional regulator of chromosomal genes and a virulence factorQ24642084
Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolatesQ24675697
A novel method for accurate operon predictions in all sequenced prokaryotesQ24791071
"Rapid-impact interventions": how a policy of integrated control for Africa's neglected tropical diseases could benefit the poorQ24810845
Co-evolution of genomes and plasmids within Chlamydia trachomatis and the emergence in Sweden of a new variant strainQ33449883
Plaque formation by and plaque cloning of Chlamydia trachomatis biovar trachomaQ33679270
Chlamydial IFN-gamma immune evasion is linked to host infection tropismQ33906721
Comparison of gamma interferon-mediated antichlamydial defense mechanisms in human and mouse cellsQ34301109
Transcriptome analysis of chlamydial growth during IFN-gamma-mediated persistence and reactivationQ34793962
The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in miceQ35080460
Nucleotide and deduced amino acid sequences for the four variable domains of the major outer membrane proteins of the 15 Chlamydia trachomatis serovars.Q35093651
Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatisQ35168447
Gene knockout mice establish a primary protective role for major histocompatibility complex class II-restricted responses in Chlamydia trachomatis genital tract infectionQ35454753
Mouse strain-dependent variation in the course and outcome of chlamydial genital tract infection is associated with differences in host response.Q35552064
Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolatesQ36259301
Black holes, antivirulence genes, and gene inactivation in the evolution of bacterial pathogensQ36711515
Identification of concomitant infection with Chlamydia trachomatis IncA-negative mutant and wild-type strains by genomic, transcriptional, and biological characterizationsQ36974505
Strain and virulence diversity in the mouse pathogen Chlamydia muridarumQ37274906
Pathogenic diversity among Chlamydia trachomatis ocular strains in nonhuman primates is affected by subtle genomic variationsQ37858264
Molecular basis defining human Chlamydia trachomatis tissue tropism. A possible role for tryptophan synthaseQ37871952
Differential sensitivity of distinct Chlamydia trachomatis isolates to IFN-gamma-mediated inhibitionQ37878818
Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort studyQ37891788
Mutation detection using a novel plant endonucleaseQ39725311
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectChlamydia trachomatisQ131065
P304page(s)3660-3668
P577publication date2010-06-14
P1433published inInfection and ImmunityQ6029193
P1476titleFrameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract
P478volume78

Reverse relations

cites work (P2860)
Q36111865A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production.
Q38738769A Primer on Infectious Disease Bacterial Genomics
Q35441545A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates
Q27014318A path forward for the chlamydial virulence factor CPAF
Q44059216Advances and Obstacles in the Genetic Dissection of Chlamydial Virulence
Q37123840Animal models for studying female genital tract infection with Chlamydia trachomatis
Q34056674Benzylidene acylhydrazides inhibit chlamydial growth in a type III secretion- and iron chelation-independent manner.
Q36950621CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract.
Q49387187Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract - A Two-Hit Hypothesis
Q91996568Chlamydia muridarum Induces Pathology in the Female Upper Genital Tract via Distinct Mechanisms
Q35465997Chlamydia psittaci genetic variants differ in virulence by modulation of host immunity
Q37834520Chlamydia trachomatis ChxR is a transcriptional regulator of virulence factors that function in in vivo host-pathogen interactions.
Q35710313Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors
Q33899758Chlamydia trachomatis polymorphic membrane protein D is a virulence factor involved in early host-cell interactions
Q36855079Chlamydia trachomatis virulence factor CT135 is stable in vivo but highly polymorphic in vitro
Q37835613Chlamydial Plasmid-Dependent Pathogenicity
Q35833861Chlamydial variants differ in ability to ascend the genital tract in the guinea pig model of chlamydial genital infection
Q37622035Comparison of Murine Cervicovaginal Infection by Chlamydial Strains: Identification of Extrusions Shed In vivo
Q34811021Culture-independent sequence analysis of Chlamydia trachomatis in urogenital specimens identifies regions of recombination and in-patient sequence mutations
Q37834533Demonstration of Persistent Infections and Genome Stability by Whole-Genome Sequencing of Repeat-Positive, Same-Serovar Chlamydia trachomatis Collected From the Female Genital Tract
Q90001369Development of Transposon Mutagenesis for Chlamydia muridarum
Q36108441Development of a pigtail macaque model of sexually transmitted infection/HIV coinfection using Chlamydia trachomatis, Trichomonas vaginalis, and SHIV(SF162P3)
Q37845073Development of a rectal sexually transmitted infection--HIV coinfection model utilizing Chlamydia trachomatis and SHIVSF162p3.
Q36698167Differences in infectivity and induction of infertility: a comparative study of Chlamydia trachomatis strains in the murine model
Q33815065Early microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection
Q35689483Effect of inflammatory response on in vivo competition between two chlamydial variants in the guinea pig model of inclusion conjunctivitis
Q36281361Expression and localization of predicted inclusion membrane proteins in Chlamydia trachomatis
Q34879947Generation of targeted Chlamydia trachomatis null mutants.
Q36159375Genomic stability of genotyping markers in Chlamydia trachomatis
Q35444634Genomic variant representation in a Chlamydia population is dynamic and adaptive with dependence on in vitro and in vivo passage
Q37836040Immunopathogenesis of Chlamydial Infections
Q35947374In Vivo and Ex Vivo Imaging Reveals a Long-Lasting Chlamydial Infection in the Mouse Gastrointestinal Tract following Genital Tract Inoculation
Q35439847In vitro passage selects for Chlamydia muridarum with enhanced infectivity in cultured cells but attenuated pathogenicity in mouse upper genital tract
Q37834302Infection of Hysterectomized Mice with Chlamydia muridarum and Chlamydia trachomatis
Q34484739Infectivity acts as in vivo selection for maintenance of the chlamydial cryptic plasmid
Q33723211Infectivity of urogenital Chlamydia trachomatis plasmid-deficient, CT135-null, and double-deficient strains in female mice
Q29032025Innate immunity is sufficient for the clearance ofChlamydia trachomatisfrom the female mouse genital tract
Q35609287Intrauterine infection with plasmid-free Chlamydia muridarum reveals a critical role of the plasmid in chlamydial ascension and establishes a model for evaluating plasmid-independent pathogenicity.
Q37546980MicroRNAs Modulate Pathogenesis Resulting from Chlamydial Infection in Mice
Q34743290Murine Chlamydia trachomatis genital infection is unaltered by depletion of CD4+ T cells and diminished adaptive immunity
Q35745572Mutational Analysis of the Chlamydia muridarum Plasticity Zone
Q44059220National Institute of Allergy and Infectious Diseases workshop report: "Chlamydia vaccines: The way forward".
Q54254256Oral Chlamydia vaccination induces transmucosal protection in the airway.
Q34146357Plasmid-cured Chlamydia caviae activates TLR2-dependent signaling and retains virulence in the guinea pig model of genital tract infection
Q36387327Population genomics of Chlamydia trachomatis: insights on drift, selection, recombination, and population structure.
Q37643910Reduced live organism recovery and lack of hydrosalpinx in mice infected with plasmid-free Chlamydia muridarum
Q36940236TLR2, TLR4 and TLR9 genotypes and haplotypes in the susceptibility to and clinical course of Chlamydia trachomatis infections in Dutch women.
Q36021473The Chlamydia muridarum Organisms Fail to Auto-Inoculate the Mouse Genital Tract after Colonization in the Gastrointestinal Tract for 70 days
Q49791375The Chlamydia trachomatis Plasmid and CT135 Virulence Factors Are Not Essential for Genital Tract Infection or Pathology in Female Pig-Tailed Macaques
Q37199905The Chlamydia-Secreted Protease CPAF Promotes Chlamydial Survival in the Mouse Lower Genital Tract
Q36513495The Chromosome-Encoded Hypothetical Protein TC0668 Is an Upper Genital Tract Pathogenicity Factor of Chlamydia muridarum
Q90138180The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg
Q60920017Therapeutic effect of a Chlamydia pecorum recombinant major outer membrane protein vaccine on ocular disease in koalas (Phascolarctos cinereus)
Q37834874Update on Chlamydia trachomatis Vaccinology
Q34739969Vaccination againstChlamydiaGenital Infection Utilizing the MurineC. muridarumModel

Search more.