Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment

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Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.79.22.14169-14178.2005
P932PMC publication ID1280210
P698PubMed publication ID16254352
P5875ResearchGate publication ID7513232

P50authorSteven G DeeksQ57425986
P2093author name stringDavid Favre
Joseph M McCune
Douglas F Nixon
Elizabeth Sinclair
Jeffrey N Martin
Priscilla Hsue
Brinda Emu
Rebecca Hoh
Walter J Moretto
P2860cites workTemporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndromeQ24648628
Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infectionQ24795912
Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsQ28146072
Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremiaQ28254584
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 geneQ28593669
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytesQ29616210
Putative immunodominant human immunodeficiency virus-specific CD8(+) T-cell responses cannot be predicted by major histocompatibility complex class I haplotypeQ33604661
Human immunodeficiency virus-specific circulating CD8 T lymphocytes have down-modulated CD3zeta and CD28, key signaling molecules for T-cell activationQ33809451
In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patientsQ33840429
Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infectionQ33869806
The role of CD4(+) T helper cells in the cytotoxic T lymphocyte response to HIV-1.Q33971012
IL-2-induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferationQ33977594
HIV-1-infected antiretroviral-treated patients with prolonged partial viral suppression: clinical, virologic, and immunologic courseQ79347477
T Cell Activation Is Associated with Lower CD4+T Cell Gains in Human Immunodeficiency Virus–Infected Patients with Sustained Viral Suppression during Antiretroviral TherapyQ34193786
Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cellsQ34289467
Discordant outcomes following failure of antiretroviral therapy are associated with substantial differences in human immunodeficiency virus-specific cellular immunityQ34976619
T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesisQ35543827
Treatment of antiretroviral-drug-resistant HIV-1 infectionQ35610798
HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic functionQ35834664
Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should knowQ35852348
Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules: effects of viral variation on cytotoxic T-lymphocyte recognitionQ35876884
Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomaticsQ36364647
HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacityQ36371562
Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and childrenQ36404594
Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4+T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2Q36474240
Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individualsQ36602397
Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progressionQ39602846
The prevalence of antiretroviral drug resistance in the United StatesQ39687529
Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occursQ41018351
The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responsesQ41870329
HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppressionQ43750477
Studies in subjects with long-term nonprogressive human immunodeficiency virus infectionQ44369963
Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functionsQ44443175
Use of overlapping peptide mixtures as antigens for cytokine flow cytometryQ45112956
Skewed maturation of memory HIV-specific CD8 T lymphocytesQ45284555
Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1.Q45699170
Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapyQ45721932
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infectionsQ45733084
Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivorsQ45747345
Quantitation of CD38 expression using QuantiBRITE beadsQ46490538
Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence.Q51995303
Immune control of HIV-1 after early treatment of acute infectionQ56961920
HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replicationQ61941182
Seventeen-colour flow cytometry: unravelling the immune systemQ62577376
Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progressionQ71803154
Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor betaQ72287439
Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDSQ73034306
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2Q74660381
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressorsQ78342521
Presence of HIV-1 Gag-specific IFN-gamma+IL-2+ and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infectionQ78551235
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
anti-retroviral agentQ50430310
P304page(s)14169-14178
P577publication date2005-11-01
P1433published inJournal of VirologyQ1251128
P1476titlePhenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment
P478volume79

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