MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers.

scientific article

MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1044099172
P356DOI10.1038/ONC.2010.233
P8608Fatcat IDrelease_b4d6hlfsqzf2pa6zxn5knv2kem
P698PubMed publication ID20603620
P5875ResearchGate publication ID45094653

P50authorJ Saadi ImamQ52581225
P2093author name stringY Chen
K Buddavarapu
M K Rao
S Ganapathy
C Camosy
J S Lee-Chang
P2860cites workThe Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1Q24564859
Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesisQ24644884
Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transitionQ24685187
Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesisQ28185761
The role of Six1 in mammalian auditory system developmentQ28188638
Six1 is required for the early organogenesis of mammalian kidneyQ28510085
Six1 controls patterning of the mouse otic vesicleQ28589213
Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryoQ28593548
Neutral red uptake assay for the estimation of cell viability/cytotoxicityQ30047632
Gene expression changes during HPV-mediated carcinogenesis: a comparison between an in vitro cell model and cervical cancerQ33860352
Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy.Q34390964
The role of microRNAs in normal and malignant hematopoiesisQ35002076
TRAIL and apoptosis induction by TNF-family death receptors.Q35591708
Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinomaQ36612365
Defining a role for the homeoprotein Six1 in EMT and mammary tumorigenesisQ37328411
Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transitionQ37328450
The tumorigenicity diversification in human embryonic kidney 293 cell line cultured in vitroQ39996786
Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival.Q40149403
Gene amplification is a mechanism of Six1 overexpression in breast cancerQ40439862
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulatorsQ40602477
Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformationQ42814954
Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient miceQ43860748
Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracilQ45064015
The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis.Q53349168
P433issue35
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
P304page(s)4971-4979
P577publication date2010-07-05
P1433published inOncogeneQ1568657
P1476titleMicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers
P478volume29

Reverse relations

cites work (P2860)
Q31133163A Bayesian integrative approach for multi-platform genomic data: A kidney cancer case study
Q52562647A step-by-step microRNA guide to cancer development and metastasis.
Q90163704Age-Related Alterations in Immune Contexture Are Associated with Aggressiveness in Rhabdomyosarcoma
Q30425832Androgen-responsive microRNAs in mouse Sertoli cells.
Q38268088Antisense therapeutics in oncology: current status
Q35310856Autoregulatory suppression of c-Myc by miR-185-3p
Q38559338Biomarkers to detect Wilms tumors in pediatric patients: where are we now?
Q38500323Cholinesterase-Targeting microRNAs Identified in silico Affect Specific Biological Processes
Q92787282Circular RNA circNHSL1 promotes gastric cancer progression through the miR-1306-3p/SIX1/vimentin axis
Q31009969DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs
Q39273744Differential expression of miRNAs in rhabdomyosarcoma and malignant rhabdoid tumor.
Q55115788Downregulation of miR-1266-5P, miR-185-5P and miR-30c-2 in prostatic cancer tissue and cell lines.
Q54322646Elevated microRNA-185 is associated with high vascular endothelial growth factor receptor 2 expression levels and high microvessel density in clear cell renal cell carcinoma.
Q36216208Epigenetic effects of selenium and their implications for health
Q36557328Exposure to airborne PM2.5 suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells
Q38868233Expression of somatostatin receptor subtype 2 in growth hormone-secreting pituitary adenoma and the regulation of miR-185.
Q34533814Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization
Q38206779Homeobox Gene Deregulation: Impact on the Hallmarks of Cancer
Q34737713Hormone-induced and DNA demethylation-induced relief of a tissue-specific and developmentally regulated block in transcriptional elongation.
Q59798393Huayu Tongmai Granules protects against vascular endothelial dysfunction via up-regulating miR-185 and down-regulating RAGE
Q39762235Human cancer classification: a systems biology- based model integrating morphology, cancer stem cells, proteomics, and genomics
Q35082591Identification and validation of miRNAs as endogenous controls for RQ-PCR in blood specimens for breast cancer studies
Q39051113Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake
Q33684857Increased Six1 expression is associated with poor prognosis in patients with osteosarcoma
Q37100069Inhibition of FoxM1-Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis
Q64964690Joint testing and false discovery rate control in high-dimensional multivariate regression.
Q99212569LncRNA-ROR/microRNA-185-3p/YAP1 axis exerts function in biological characteristics of osteosarcoma cells
Q55399851MiR-1180-5p regulates apoptosis of Wilms' tumor by targeting p73.
Q39210882MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine
Q42799144MiR-185 inhibits 3T3-L1 cell differentiation by targeting SREBP-1.
Q39472499MiR-384 regulated IRS1 expression and suppressed cell proliferation of human hepatocellular carcinoma
Q33598225MicroRNA-146a affects the chemotherapeutic sensitivity and prognosis of advanced gastric cancer through the regulation of LIN52
Q37726121MicroRNA-185 regulates chemotherapeutic sensitivity in gastric cancer by targeting apoptosis repressor with caspase recruitment domain
Q39192939MicroRNA-185 suppresses proliferation, invasion, migration, and tumorigenicity of human prostate cancer cells through targeting androgen receptor
Q35057752MicroRNA-185 targets SOCS3 to inhibit beta-cell dysfunction in diabetes
Q39766103MicroRNA-185-5p mediates regulation of SREBP2 expression by hepatitis C virus core protein
Q33613370MicroRNA-30a regulates zebrafish myogenesis through targeting the transcription factor Six1
Q38815056MicroRNA: a connecting road between apoptosis and cholesterol metabolism
Q34696427MicroRNAs and their applications in kidney diseases
Q34042888MicroRNAs associated with metastatic prostate cancer
Q39333266MicroRNAs in gynecological cancers: Small molecules with big implications
Q38118222MicroRNAs involved in skeletal muscle development and their roles in rhabdomyosarcoma pathogenesis.
Q38133419MicroRNAs: potential regulators of renal development genes that contribute to CAKUT.
Q37792874MicroRNAs: tiny targets for engineering CHO cell phenotypes?
Q35135678Minireview: The roles of small RNA pathways in reproductive medicine
Q39429443Mutual enrichment in aggregated ranked lists with applications to gene expression regulation
Q37837735New players in ovarian cancer
Q60958994Non-Coding RNAs in Breast Cancer: Intracellular and Intercellular Communication
Q35853714On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics
Q89852415Overexpression of microRNA-185 alleviates intervertebral disc degeneration through inactivation of the Wnt/β-catenin signaling pathway and downregulation of Galectin-3
Q37291394Potentials of the elevated circulating miR-185 level as a biomarker for early diagnosis of HBV-related liver fibrosis
Q33889489Regulation of cancer aggressive features in melanoma cells by microRNAs
Q36985088Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition
Q38230205Restoring TRAIL mediated signaling in ovarian cancer cells.
Q98771139Roles of microRNAs in Ovarian Cancer Tumorigenesis: Two Decades Later, What Have We Learned?
Q92542107SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1
Q36059882STIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer
Q33597712Six1 expression is associated with a poor prognosis in patients with glioma
Q34634833Six1 promotes proliferation of pancreatic cancer cells via upregulation of cyclin D1 expression
Q38184513Six1: a critical transcription factor in tumorigenesis
Q35854054TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185
Q38058733Targeting microRNAs to modulate TRAIL-induced apoptosis of cancer cells
Q54964308The Role of MicroRNAs in Kidney Disease.
Q35107900The SIX1-EYA transcriptional complex as a therapeutic target in cancer
Q36367578The impact of microRNA expression on cellular proliferation
Q26747218The retinal determination gene network: from developmental regulator to cancer therapeutic target
Q38658528The roles of microRNAs in Wilms' tumors
Q35173260The yin and yang of kidney development and Wilms' tumors
Q37234148Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1.
Q38066406While at Rome miRNA and TRAIL do whatever BCR-ABL commands to do.
Q58763916ZNF139 increases multidrug resistance in gastric cancer cells by inhibiting
Q35677296miR-1228 promotes the proliferation and metastasis of hepatoma cells through a p53 forward feedback loop
Q33597730miR-185 enhances the inhibition of proliferation and migration induced by ionizing radiation in melanoma
Q39041981miR-185 is an independent prognosis factor and suppresses tumor metastasis in gastric cancer
Q39376552miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms
Q49729843miR-204-5p suppresses hepatocellular cancer proliferation by regulating homeoprotein SIX1 expression.
Q64107786miR-483-5p Targets MKNK1 to Suppress Wilms' Tumor Cell Proliferation and Apoptosis In Vitro and In Vivo
Q37229470miR-99 inhibits cervical carcinoma cell proliferation by targeting TRIB2
Q64099326miR‑185‑5p targets ROCK2 and inhibits cell migration and invasion of hepatocellular carcinoma
Q34269240microRNA expression and biogenesis in cellular response to ionizing radiation

Search more.