An evaluation of MSDC-0160, a prototype mTOT modulating insulin sensitizer, in patients with mild Alzheimer's disease.

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An evaluation of MSDC-0160, a prototype mTOT modulating insulin sensitizer, in patients with mild Alzheimer's disease. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2174/1567205011666140616113406
P932PMC publication ID4153084
P698PubMed publication ID24931567
P5875ResearchGate publication ID263130866

P50authorRaj C. ShahQ46413647
Ana W CapuanoQ104617620
P2093author name stringDebra A Fleischman
Jerry R Colca
Dawn C Matthews
Randolph D Andrews
James T VanderLugt
P2860cites workMitochondrial Aβ A potential cause of metabolic dysfunction in Alzheimer's diseaseQ22242986
Brain fuel metabolism, aging, and Alzheimer's diseaseQ24625859
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Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic interventionQ26865358
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's DiseaseQ27860795
Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's diseaseQ28259585
Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteinsQ28488095
Methylphenidate decreased the amount of glucose needed by the brain to perform a cognitive taskQ33328509
Microglial activation and amyloid deposition in mild cognitive impairment: a PET studyQ33634089
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Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI.Q33939971
Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia?Q34464761
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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive declineQ35858095
Mitoenergetic failure in Alzheimer diseaseQ36522646
Clinical proof-of-concept study with MSDC-0160, a prototype mTOT-modulating insulin sensitizerQ36705829
Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.Q36747796
Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's diseaseQ37219754
Food for thought: the importance of glucose and other energy substrates for sustaining brain function under varying levels of activityQ37826510
Rosiglitazone and pioglitazone for the treatment of Alzheimer's diseaseQ37949572
Altering mitochondrial dysfunction as an approach to treating Alzheimer's diseaseQ38030125
Mitochondrial target of thiazolidinedionesQ38207747
The perils of Alzheimer's drug developmentQ42560979
A multi-center randomized proof-of-concept clinical trial applying [¹⁸F]FDG-PET for evaluation of metabolic therapy with rosiglitazone XR in mild to moderate Alzheimer's diseaseQ42866942
The role of tumor necrosis factor-alpha in cognitive improvement after peroxisome proliferator-activator receptor gamma agonist pioglitazone treatment in Alzheimer's diseaseQ42932695
Insulin sensitizers in 2013: new insights for the development of novel therapeutic agents to treat metabolic diseasesQ44635317
Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitusQ46146314
Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's diseaseQ48218480
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Pioglitazone does not increase cerebral glucose utilisation in a murine model of Alzheimer's disease and decreases it in wild-type miceQ48475665
Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease.Q51411852
Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: two phase 3 studiesQ84140005
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P433issue6
P921main subjectAlzheimer's diseaseQ11081
preproinsulinQ7240673
P304page(s)564-573
P577publication date2014-01-01
P1433published inCurrent Alzheimer ResearchQ5195031
P1476titleAn evaluation of MSDC-0160, a prototype mTOT modulating insulin sensitizer, in patients with mild Alzheimer's disease
P478volume11

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cites work (P2860)
Q33808884Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets.
Q90679732Drug Repurposing in Parkinson's Disease
Q39022532Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends
Q48402725Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease
Q92743677Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer
Q38610829The TZD insulin sensitizer clue provides a new route into diabetes drug discovery
Q52699083Treating fatty liver disease by modulating mitochondrial pyruvate metabolism.

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