Protein binding specificity versus promiscuity.

scientific article

Protein binding specificity versus promiscuity. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.SBI.2010.10.002
P932PMC publication ID3053118
P698PubMed publication ID21071205
P5875ResearchGate publication ID47755151

P50authorAmy KeatingQ28914832
P2093author name stringGideon Schreiber
P2860cites workPDZ domain binding selectivity is optimized across the mouse proteomeQ40191457
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Automated design of specificity in molecular recognitionQ46103643
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Computational redesign of a protein-protein interface for high affinity and binding specificity using modular architecture and naturally occurring template fragmentsQ46898850
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Cohen's Conjecture, Howard's Hypothesis, and Ptashne's Ptruth: an exploration of the relationship between affinity and specificity.Q51722298
The Structural Basis of Sirtuin Substrate Affinity†,‡Q58375361
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Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arraysQ24297419
Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramerQ24301745
Regulation of p53 activity through lysine methylationQ24311514
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A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 networkQ24600216
Diversity of protein-protein interactionsQ24681566
Structure of the negative regulatory domain of p53 bound to S100B(betabeta)Q27625154
Crystal structure and kinetic analysis of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamaseQ27635017
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin AQ27640246
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activationQ27643078
Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 familyQ27645935
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradationQ27649579
Structural plasticity underpins promiscuous binding of the prosurvival protein A1Q27650558
Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solutionQ27650851
Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1Q27651003
A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein–Protein InterfacesQ27651036
Analysis of coiled-coil interactions between core proteins of the spindle pole bodyQ27652493
Inhibition of Wnt signaling by Dishevelled PDZ peptidesQ27653983
Insights into positive and negative requirements for protein-protein interactions by crystallographic analysis of the beta-lactamase inhibitory proteins BLIP, BLIP-I, and BLPQ27654501
Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind LigandsQ27657282
Structural and Biochemical Characterization of the Interaction between KPC-2 β-Lactamase and β-Lactamase Inhibitor Protein,Q27657333
Following evolutionary paths to protein-protein interactions with high affinity and selectivityQ27657425
Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changesQ27658925
Structural Insight into p53 Recognition by the 53BP1 Tandem Tudor DomainQ27660302
What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of RafQ27660404
Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xLQ27660407
A Synthetic Coiled-Coil Interactome Provides Heterospecific Modules for Molecular EngineeringQ27660517
The structural and energetic basis for high selectivity in a high-affinity protein-protein interactionQ27661721
The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizerQ27662487
A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiaeQ27938148
Comprehensive identification of human bZIP interactions with coiled-coil arraysQ28178993
Beauty is in the eye of the beholder: proteins can recognize binding sites of homologous proteins in more than one wayQ28474495
Multi-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibilityQ28914723
Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding peptidesQ30163803
Conserved tertiary couplings stabilize elements in the PDZ fold, leading to characteristic patterns of domain conformational flexibility.Q30384111
Intrinsically disordered proteins in bcl-2 regulated apoptosis.Q30389323
Positive aspects of negative design: simultaneous selection of specificity and interaction stabilityQ33280817
Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partnersQ33325589
A specificity map for the PDZ domain familyQ33373127
Two-state selection of conformation-specific antibodiesQ33408112
Graphical models of protein-protein interaction specificity from correlated mutations and interaction dataQ33420576
Rapid evolution of functional complexity in a domain familyQ33500939
Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.Q33502518
Tradeoff between stability and multispecificity in the design of promiscuous proteinsQ33521300
The functional capacity of the natural amino acids for molecular recognitionQ33552368
Models of macromolecular crowding effects and the need for quantitative comparisons with experimentQ33788048
Laminin chain assembly is regulated by specific coiled-coil interactionsQ33882269
Effects of proteins on protein diffusion.Q33969533
Computational design of second-site suppressor mutations at protein-protein interfacesQ33991441
Enzyme promiscuity: a mechanistic and evolutionary perspectiveQ34021669
A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex.Q34375789
Design of protein-interaction specificity gives selective bZIP-binding peptides.Q34975999
It takes two to tango: the structure and function of LIM, RING, PHD and MYND domains.Q35013680
Entropic contributions and the influence of the hydrophobic environment in promiscuous protein-protein associationQ36667540
Predicting PDZ domain-peptide interactions from primary sequencesQ37127222
Protein-protein interaction networks: how can a hub protein bind so many different partners?Q37616866
Computer-aided design of functional protein interactionsQ37617943
Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: application to the Bim BH3 domainQ39639296
Rewiring the specificity of two-component signal transduction systemsQ39940178
P433issue1
P304page(s)50-61
P577publication date2010-11-09
P1433published inCurrent Opinion in Structural BiologyQ15758416
P1476titleProtein binding specificity versus promiscuity
P478volume21

Reverse relations

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