Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury

scientific article

Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/JCBFM.2014.105
P8608Fatcat IDrelease_kbhmdclgmjh6vhycccafiglojq
P932PMC publication ID4158661
P698PubMed publication ID24917042
P5875ResearchGate publication ID263014867

P50authorKevin K W WangQ37837051
P2093author name stringClaudia S Robertson
Fan Lin
Zhihui Yang
P2860cites workThe cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injuryQ24601910
Structural insights into TDP-43 in nucleic-acid binding and domain interactionsQ24647225
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosisQ28131672
The pathobiology of blast injuries and blast-induced neurotrauma as identified using a new experimental model of injury in miceQ33448563
A Drosophila model for TDP-43 proteinopathyQ33733651
The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanismQ33786698
Calpain and caspase: can you tell the difference?Q33815206
Comparison of assessment of pigeon sperm viability by contrast-phase microscope (eosin-nigrosin staining) and flow cytometry (SYBR-14/propidium iodide (PI) staining) [evaluation of pigeon sperm viability].Q34067776
TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.Q34131994
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in miceQ34519947
TDP-43 in aging and Alzheimer's disease - a reviewQ34566756
Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tanglesQ34869120
Clinicopathological characterization of Pick's disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusionsQ34937742
Gains or losses: molecular mechanisms of TDP43-mediated neurodegenerationQ35773678
Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosisQ36734898
TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degenerationQ36766654
Amyloid-β Peptides and Tau Protein as Biomarkers in Cerebrospinal and Interstitial Fluid Following Traumatic Brain Injury: A Review of Experimental and Clinical StudiesQ36955963
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicityQ37164410
TDP-43: a novel neurodegenerative proteinopathyQ37183193
TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicityQ37339064
Calpain as a therapeutic target in traumatic brain injuryQ37686765
Acute and chronically increased immunoreactivity to phosphorylation-independent but not pathological TDP-43 after a single traumatic brain injury in humansQ37691547
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulinQ39838808
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.Q39839659
Prion-like disorders: blurring the divide between transmissibility and infectivityQ39863503
Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's diseaseQ39960293
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.Q40075711
Caspase-cleaved TAR DNA-binding protein-43 in Pick's diseaseQ40098657
Calpain as a novel target for treating acute neurodegenerative disordersQ40369892
Multiple alphaII-spectrin breakdown products distinguish calpain and caspase dominated necrotic and apoptotic cell death pathwaysQ43273248
Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in miceQ44261064
Biomarkers in the clinical diagnosis and management of traumatic brain injuryQ45061432
Alzheimer CSF biomarkers in routine clinical settingQ45205291
Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington diseaseQ45291590
Regional distribution of TDP-43 inclusions in Alzheimer disease (AD) brains: their relation to AD common pathologyQ47861971
Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injuryQ48233639
A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathologyQ48249180
Traumatic brain injury and time to onset of Alzheimer's disease: a population-based studyQ48308861
The cognitive profile and CSF biomarkers in dementia with Lewy bodies and Parkinson's disease dementia.Q51027167
Systems biomarkers as acute diagnostics and chronic monitoring tools for traumatic brain injuryQ58114628
P4510describes a project that usesImageJQ1659584
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectproteolysisQ33123
traumatic brain injuryQ1995526
neurotoxicityQ3338704
P304page(s)1444-1452
P577publication date2014-06-11
P1433published inJournal of Cerebral Blood Flow & MetabolismQ14663525
P1476titleDual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury
P478volume34

Reverse relations

cites work (P2860)
Q966908583,6'-Dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation
Q30361334Acute death of astrocytes in blast-exposed rat organotypic hippocampal slice cultures
Q91670748Ammonia induces calpain-dependent cleavage of CRMP-2 during neurite degeneration in primary cultured neurons
Q47862152An update on diagnostic and prognostic biomarkers for traumatic brain injury.
Q91705054Biological links between traumatic brain injury and Parkinson's disease
Q104134973Chronic traumatic encephalopathy-a blueprint for the bridge between neurological and psychiatric disorders
Q37662585Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.
Q38784171Degradomics in Neurotrauma: Profiling Traumatic Brain Injury
Q64069747Effect of poly-arginine R18 on neurocyte cell growth via autophagy in traumatic brain injury
Q42409526Examining the Neural and Astroglial Protective Effects of Cellular Prion Protein Expression and Cell Death Protease Inhibition in Mouse Cerebrocortical Mixed Cultures
Q41480053Overexpression of CRF in the BNST diminishes dysphoria but not anxiety-like behavior in nicotine withdrawing rats.
Q37061236Plasma Anti-Glial Fibrillary Acidic Protein Autoantibody Levels during the Acute and Chronic Phases of Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot Study
Q91955777Prospective clinical biomarkers of caspase-mediated apoptosis associated with neuronal and neurovascular damage following stroke and other severe brain injuries: Implications for chronic neurodegeneration
Q45327759Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction.
Q58726656Subarachnoid hemorrhage enhances the expression of TDP-43 in the brain of experimental rats and human subjects
Q35234677TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies
Q92113086TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response
Q33740999TDP-43 suppresses tau expression via promoting its mRNA instability
Q35709639Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model
Q64054884The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD
Q91971334The Role of TDP-43 in Military-Relevant TBI and Chronic Neurodegeneration
Q41873070The functional and structural changes in the basilar artery due to overpressure blast injury.
Q47693846The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration
Q47951993Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease.
Q36373142Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant
Q55710510What triggers tauopathy in chronic traumatic encephalopathy?

Search more.