Lutein inhibits the migration of retinal pigment epithelial cells via cytosolic and mitochondrial Akt pathways (lutein inhibits RPE cells migration).

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Lutein inhibits the migration of retinal pigment epithelial cells via cytosolic and mitochondrial Akt pathways (lutein inhibits RPE cells migration). is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/IJMS150813755
P932PMC publication ID4159823
P698PubMed publication ID25110866
P5875ResearchGate publication ID267756631

P2093author name stringHan-Min Chen
Victor Chia-Hsiang Lin
Chi-Feng Hung
Chia-Chun Wu
Ching-Chieh Su
Chi-Ming Chan
Chien-Yu Hsiao
Pei-Lan Lee
P2860cites workSignaling pathways involved in PDGF-evoked cellular responses in human RPE cellsQ83187768
Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioningQ83316180
The pathophysiology of proliferative vitreoretinopathy in its managementQ93588666
Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoidsQ28609442
Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activationQ31034955
The role of retinal pigment epithelium in the involution of subretinal neovascularization.Q31145223
A role of the retinal pigment epithelium in the involution of subretinal neovascularizationQ33257671
Platelet-derived growth factor plays a key role in proliferative vitreoretinopathyQ33875969
The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier--implications for the pathogenesis of diabetic retinopathy.Q34100527
Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye.Q34182531
Versatility of the mitochondrial protein import machineryQ34238028
Inhibitory effects of resveratrol on PDGF-BB-induced retinal pigment epithelial cell migration via PDGFRβ, PI3K/Akt and MAPK pathwaysQ34607101
Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophyQ35033113
A naturally occurring carotenoid, lutein, reduces PDGF and H₂O₂ signaling and compromised migration in cultured vascular smooth muscle cellsQ35799977
Mitochondrial Akt-regulated mitochondrial apoptosis signaling in cardiac muscle cellsQ35964963
Growth factors in retinal diseases: proliferative vitreoretinopathy, proliferative diabetic retinopathy, and retinal degenerationQ36015882
PI3K-Akt signaling and viral infectionQ37355200
Insulin stimulates Akt translocation to mitochondria: implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardiumQ37413593
Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardiumQ37413596
Carotenoids and their isomers: color pigments in fruits and vegetablesQ37845124
The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: role of H(2)O(2) in NF-kappaB activationQ38289319
Lutein protects retinal pigment epithelium from cytotoxic oxidative stressQ39124583
Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K/Akt and MAPK pathwaysQ39815234
Effects of (-)-epigallocatechin gallate on RPE cell migration and adhesion.Q39884097
Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell deathQ39961067
beta-Carotene conversion into vitamin A in human retinal pigment epithelial cellsQ40368582
PI3K and PLCgamma play a central role in experimental PVR.Q40753941
Pathogenic mechanisms in proliferative vitreoretinopathyQ41359208
Application of Lutein and Zeaxanthin in nonproliferative diabetic retinopathyQ42132173
Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53.Q42793339
An in vivo gene therapy approach for experimental proliferative vitreoretinopathy using the truncated platelet-derived growth factor alpha receptor.Q44046014
Platelet-derived growth factor receptor kinase inhibitor AG1295 and inhibition of experimental proliferative vitreoretinopathyQ44435061
Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cellsQ44457883
Insulin-like growth factor-1 prevents loss of electrochemical gradient in cardiac muscle mitochondria via activation of PI 3 kinase/Akt pathway.Q44532294
Effects of vitamin A on retinal pigment epithelial cells in vitroQ44975095
Pharmacological implications from the adhesion-induced signaling profiles in cultured human retinal pigment epithelial cellsQ45128721
Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytesQ48014037
Silk lutein extract and its combination with vitamin E reduce UVB-mediated oxidative damage to retinal pigment epithelial cellsQ50234905
Dietary supplementation of lutein reduces colon carcinogenesis in DMH-treated rats by modulating K-ras, PKB, and β-catenin proteins.Q54628946
Apoptosis in proliferative vitreoretinal disorders: possible involvement of TGF-beta-induced RPE cell apoptosis.Q64958004
Platelet-derived growth factor ligands and receptors immunolocalized in proliferative retinal diseasesQ72196215
Proliferative vitreoretinopathy: an overviewQ77144020
Carotenoids enhance phosphorylation of Akt and suppress tissue factor activity in human endothelial cellsQ82965951
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectcell migrationQ189092
P304page(s)13755-13767
P577publication date2014-08-08
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleLutein inhibits the migration of retinal pigment epithelial cells via cytosolic and mitochondrial Akt pathways (lutein inhibits RPE cells migration).
P478volume15

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cites work (P2860)
Q91640915Adjuvant Therapies in Diabetic Retinopathy as an Early Approach to Delay Its Progression: The Importance of Oxidative Stress and Inflammation
Q36980308Current results on the potential health benefits of lutein
Q37377481Development of an Advanced HPLC-MS/MS Method for the Determination of Carotenoids and Fat-Soluble Vitamins in Human Plasma.
Q47096013Effects of the Macular Carotenoid Lutein in Human Retinal Pigment Epithelial Cells
Q47114241Odorant Receptor 51E2 Agonist β-ionone Regulates RPE Cell Migration and Proliferation
Q90070032Oxidative Stress as the Main Target in Diabetic Retinopathy Pathophysiology
Q60306280Quercetin inhibits transforming growth factor β1-induced epithelial-mesenchymal transition in human retinal pigment epithelial cells via the Smad pathway
Q38864556The influences of purple sweet potato anthocyanin on the growth characteristics of human retinal pigment epithelial cells

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