Recommended design features of future clinical trials of antibacterial agents for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia

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Recommended design features of future clinical trials of antibacterial agents for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1086/653065
P932PMC publication ID2947853
P698PubMed publication ID20597666
P5875ResearchGate publication ID51444087

P2093author name stringGeorge Talbot
Brad Spellberg
American Thoracic Society (ATS)
Infectious Diseases Society of America (IDSA)
American College of Chest Physicians (ACCP)
Society of Critical Care Medicine (SCCM)
P2860cites workResistance in Nonfermenting Gram-Negative Bacteria: Multidrug Resistance to the MaximumQ21710731
Guidelines for the Management of Adults with Hospital-acquired, Ventilator-associated, and Healthcare-associated PneumoniaQ22241905
Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPEQ28276828
Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumoniaQ28286874
Inadequate treatment of ventilator-associated pneumonia: risk factors and impact on outcomesQ79917087
Safety and efficacy of colistin compared with imipenem in the treatment of ventilator-associated pneumonia: a matched case-control studyQ80387733
Antimicrobial agents for complicated skin and skin-structure infections: justification of noninferiority margins in the absence of placebo-controlled trialsQ28393128
Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of AmericaQ29616084
The "zero risk" concept for hospital-acquired infections: a risky business!Q30379162
Considerations unique to pediatrics for clinical trial design in hospital-acquired pneumonia and ventilator-associated pneumoniaQ33624059
Position paper: recommended design features of future clinical trials of antibacterial agents for community-acquired pneumoniaQ33684318
Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescriptionQ33912931
Blinded invasive diagnostic procedures in ventilator-associated pneumoniaQ33921198
Recommendations for treatment of hospital-acquired and ventilator-associated pneumonia: review of recent international guidelinesQ34123866
Nosocomial infections due to multidrug-resistant Pseudomonas aeruginosa: epidemiology and treatment optionsQ36268383
The epidemiological profile of infections with multidrug-resistant Pseudomonas aeruginosa and Acinetobacter speciesQ36559359
Parenteral and inhaled colistin for treatment of ventilator-associated pneumoniaQ36559388
The clinical pulmonary infection score poorly predicts pneumonia in patients with burnsQ36702692
Pandrug-resistant Gram-negative bacteria: the dawn of the post-antibiotic era?Q36738598
Does this patient have ventilator-associated pneumonia?Q36787675
Acinetobacter infectionQ37114411
Issues in noninferiority trials: the evidence in community-acquired pneumoniaQ37170063
Health care-associated pneumonia: identification and initial management in the ED.Q37207881
Executive summary: workshop on issues in the design and conduct of clinical trials of antibacterial drugs in the treatment of community-acquired pneumoniaQ37217221
Multidrug-resistant Acinetobacter infection mortality rate and length of hospitalizationQ37302581
Historical and regulatory perspectives on the treatment effect of antibacterial drugs for community-acquired pneumoniaQ37318215
Pharmacokinetic-pharmacodynamic considerations in the design of hospital-acquired or ventilator-associated bacterial pneumonia studies: look before you leap!Q37769530
End points in hospital-acquired pneumonia and/or ventilator-associated pneumonia clinical trials: food and drug administration perspectiveQ37769532
Hospital-acquired pneumonia, health care-associated pneumonia, ventilator-associated pneumonia, and ventilator-associated tracheobronchitis: definitions and challenges in trial designQ37769534
Surrogate markers and microbiologic end pointsQ37769536
Ventilator-associated pneumonia: the clinical pulmonary infection score as a surrogate for diagnostics and outcomeQ37769537
Considerations in undertaking a clinical development program for hospital-acquired bacterial pneumonia and/or ventilator-associated bacterial pneumoniaQ37769538
Registration trials of antibacterial drugs for the treatment of nosocomial pneumoniaQ37769540
Challenges in the design and conduct of clinical trials for hospital-acquired pneumonia and ventilator-associated pneumonia: an industry perspectiveQ37769541
Treatment guidelines and outcomes of hospital-acquired and ventilator-associated pneumoniaQ37769543
Other therapeutic modalities and practices: implications for clinical trials of hospital-acquired or ventilator-associated pneumoniaQ37769544
Ventilator-associated tracheobronchitis and pneumonia: thinking outside the box.Q37769545
Use of severity scoring and stratification factors in clinical trials of hospital-acquired and ventilator-associated pneumoniaQ37769546
Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumoniaQ37769547
Diagnostic techniques and procedures for establishing the microbial etiology of ventilator-associated pneumonia for clinical trials: the pros for quantitative culturesQ37769548
The argument against using quantitative cultures in clinical trials and for the management of ventilator-associated pneumoniaQ37769549
Pseudomonas aeruginosa susceptible only to colistin in intensive care unit patientsQ39211340
Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumoniaQ39608037
Impact of adequacy of initial antimicrobial therapy on the prognosis of patients with ventilator-associated pneumoniaQ39661220
Predictors of 30-day mortality and hospital costs in patients with ventilator-associated pneumonia attributed to potentially antibiotic-resistant gram-negative bacteriaQ39855993
Microscopic and bacteriological comparison of paired sputa and transtracheal aspiratesQ40237036
Correlates of clinical failure in ventilator-associated pneumonia: insights from a large, randomized trialQ40423921
Bacterial sputum cultures. A clinician's viewpointQ40870667
Infections with Acinetobacter calcoaceticus (Herellea vaginicola): clinical and laboratory studiesQ40892705
The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of AmericaQ41445493
High tigecycline resistance in multidrug-resistant Acinetobacter baumannii.Q42165253
Resolution of ventilator-associated pneumonia: prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcomeQ43521705
A step closer to extreme drug resistance (XDR) in gram-negative bacilliQ43876962
Combined endpoints: can we use them?Q44153771
Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluidQ44492283
Predictive value of broncho-alveolar lavage fluid Gram's stain in the diagnosis of ventilator-associated pneumonia: a prospective studyQ44590378
Nosocomial infections in medical intensive care units in the United States. National Nosocomial Infections Surveillance SystemQ44727502
The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory CommitteeQ45265404
Late onset ventilator-associated pneumonia due to multidrug-resistant Acinetobacter spp.: experience with tigecyclineQ46083242
Safety and efficacy of colistin in Acinetobacter and Pseudomonas infections: a prospective cohort studyQ46571062
Effects of prior effective therapy on the efficacy of daptomycin and ceftriaxone for the treatment of community-acquired pneumoniaQ46620650
Trends in antimicrobial resistance in health care-associated pathogens and effect on treatmentQ46851716
Appropriateness and delay to initiate therapy in ventilator-associated pneumoniaQ46875327
Efficacy of adequate early antibiotic therapy in ventilator-associated pneumonia: influence of disease severity.Q47968515
Imipenem resistance among pseudomonas aeruginosa isolates: risk factors for infection and impact of resistance on clinical and economic outcomes.Q50788076
Microbiology of ventilator-associated pneumonia compared with that of hospital-acquired pneumonia.Q50981341
The futility of the clinical pulmonary infection score in trauma patients.Q51249149
Ventilator-associated pneumonia: breaking the vicious circle of antibiotic overuse.Q51715668
Nosocomial pneumonia. A multivariate analysis of risk and prognosis.Q52573110
Pneumonia in an intensive care unit. A 30-month experience.Q53699257
Noninvasive versus invasive microbial investigation in ventilator-associated pneumonia: evaluation of outcome.Q53908059
Ventilator-Associated PneumoniaQ57237894
Intravenous Colistin as Therapy for Nosocomial Infections Caused by Multidrug‐Resistant Pseudomonas aeruginosa and Acinetobacter baumanniiQ63197407
Nosocomial infections in elderly patients in the United States, 1986-1990. National Nosocomial Infections Surveillance SystemQ64128276
Microscopic and baceriologic analysis of expectorated sputumQ66924649
Detection of nosocomial lung infection in ventilated patients. Use of a protected specimen brush and quantitative culture techniques in 147 patientsQ70414345
Diagnosis and treatment of ventilator-associated pneumonia--impact on survival. A decision analysisQ71692585
The safety and diagnostic accuracy of minibronchoalveolar lavage in patients with suspected ventilator-associated pneumoniaQ72157684
Diagnostic accuracy of protected catheter sampling in ventilator-associated bacterial pneumoniaQ73386574
Clinical criteria in the diagnosis of ventilator-associated pneumoniaQ73803755
Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumoniaQ73984729
Impact of invasive and noninvasive quantitative culture sampling on outcome of ventilator-associated pneumonia: a pilot studyQ74225356
The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumoniaQ74304398
The long range effect of antibacterial therapy on pneumonia, empyema, bronchiectasis and pulmonary abscess; an analysis of incidence and mortality in 74,489 admissions to a Children's Hospital in twenty yearsQ75940703
Hospital-acquired pneumonia: epidemiology, etiology, and treatmentQ77434764
A randomized trial of diagnostic techniques for ventilator-associated pneumoniaQ79445509
Diagnosis of ventilator-associated pneumoniaQ79445517
The changing global epidemiology of Acinetobacter baumannii infections: a development with major public health implicationsQ79845986
P407language of work or nameEnglishQ1860
P921main subjectventilatorQ813243
pneumoniaQ12192
bacterial pneumoniaQ3776920
P304page(s)S150-70
P577publication date2010-08-01
P1433published inClinical Infectious DiseasesQ5133764
P1476titleRecommended design features of future clinical trials of antibacterial agents for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia
P478volume51 Suppl 1