Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration--time product.

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Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration--time product. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1020162457
P356DOI10.1007/BF00262767
P698PubMed publication ID3129204

P2093author name stringT Kobayashi
Y Sugiyama
S Ozawa
M Inaba
Y Mitsuhashi
P2860cites workAnticancer drug pharmacodynamicsQ39819996
Anticancer drugs: effect on the cloning of Raji lymphoma cells in soft agar.Q44477245
Quantitative dose-response relations for the cytotoxic activity of chloroethylnitrosoureas in cell cultureQ48975142
Dosage regimen design for pharmaceutical studies conducted in animals.Q52429035
A pharmacokinetic analysis program (multi) for microcomputerQ52732710
Interrelationships of some chemical, physicochemical, and biological activities of several 1-(2-haloethyl)-1-nitrosoureas.Q54579562
Quantitative clonal growth of mammalian cells: its application for quantitative study of cytocidal action of Mitomycin-CQ69455757
Clinical anticancer pharmacology: some pharmacokinetic considerationsQ69612825
Pharmacodynamics of Chemotherapeutic Effects: Dose-Time-Response Relationships for Phase-Nonspecific AgentsQ70730344
Concentration and time-dependent inter-relationships for antitumour drug cytotoxicities against tumour cells in vitroQ71232306
Metabolic activation of mitomycin C by liver microsomes and nucleiQ71617942
Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedulesQ71718328
P433issue3
P304page(s)185-190
P577publication date1988-01-01
P1433published inCancer Chemotherapy and PharmacologyQ326137
P1476titleCell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration--time product.
P478volume21

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cites work (P2860)
Q59803910(L.) P. Royen Leaf Water Extract Induces Apoptosis in Human Hepatocellular Carcinoma (HepG2) Cells via ERK1/2/Akt1/JNK1 Signaling Pathways
Q34771640A mathematical model for cisplatin cellular pharmacodynamics.
Q41942293A mathematical model for thermosensitive liposomal delivery of Doxorubicin to solid tumour
Q36858196A phase II study evaluating the use of concurrent mitomycin C and capecitabine in patients with advanced unresectable pseudomyxoma peritonei
Q40233201A precise pharmacodynamic study showing the advantage of a marked reduction in cardiotoxicity in continuous infusion of doxorubicin
Q43553544Antitumor activity and pharmacokinetics of TAS-106, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine
Q52183791Application of logistic growth model to pharmacodynamic analysis of in vitro bactericidal kinetics.
Q39986942Cell cycle checkpoint models for cellular pharmacology of paclitaxel and platinum drugs
Q41632267Cell-killing activity and kinetic analysis of a novel antitumor compound NC-190, a benzo[a]phenazine derivative
Q64072233Cisplatin Pharmacodynamics Following Endobronchial Ultrasound-Guided Transbronchial Needle Injection into Lung Tumors
Q40181972Cisplatin-induced hair cell loss in zebrafish (Danio rerio) lateral line
Q44412196Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo
Q31719328Cyclophosphamide and 5-fluorouracil act synergistically in ovarian clear cell adenocarcinoma cells
Q78198994Development of a pharmacokinetic/pharmacodynamic (PK/PD)-simulation system for doxorubicin in long circulating liposomes in mice using peritoneal P388
Q55234138Different modes of cell-killing action between DNA topoisomerase I and II inhibitors revealed by kinetic analysis.
Q42281324Implantation treatment method of slow release anticancer doxorubicin containing hydroxyapatite (DOX-HAP) complex. A basic study of a new treatment for hepatic cancer
Q71585950In vitro investigation of a combination of two drugs, cisplatin and carboplatin, as a function of the area under the c/t curve
Q42817957Increased sensitivity to long-term 5-fluorouracil exposure of human colon cancer HT-29 cells resistant to short-term exposure
Q35093902Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa
Q28485922Investigation of the spatiotemporal responses of nanoparticles in tumor tissues with a small-scale mathematical model
Q44885986Kinetic analysis of 5-fluorouracil action against various cancer cells
Q52426060Kinetic analysis of the in vitro cell-killing action of neocarzinostatin.
Q36910615Modeling NSCLC progression: recent advances and opportunities available
Q92617950Modelling drug transport during intraperitoneal chemotherapy
Q55482402Neurotoxicity and pharmacokinetics of ventriculolumbar perfusion of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU) in dogs.
Q78199005Optimization of antitumor effect of liposomally encapsulated doxorubicin based on simulations by pharmacokinetic/pharmacodynamic modeling
Q73850585Pharmacokinetic/pharmacodynamic modeling of antitumor agents encapsulated into liposomes
Q77811663Physicochemical factors for cytotoxic activity in platinum dinuclear complexes with pyrimidine and imide ligands
Q52506174Prediction of ACNU plasma concentration-time profiles in humans by animal scale-up.
Q49129434Randomized comparison of intra-arterial versus intravenous infusion of ACNU for newly diagnosed patients with glioblastoma
Q40722986Sensitivity to anticancer agents and resistance mechanisms in clear cell carcinoma of the ovary
Q77809322Sequence-dependent antitumour efficacy of combination chemotherapy of nedaplatin, a novel platinum complex, with 5-fluorouracil in an in vivo murine tumour model
Q37217739The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104.
Q73611462The effect of locally implanted complexes of adriamycin-hydroxyapatite complexes on tumor--study of a new alternative treatment for hepatic cancer
Q34768920Two-mechanism peak concentration model for cellular pharmacodynamics of Doxorubicin
Q41646104Unusual dynamics of killing of cultured Lewis lung cells by the DNA-intercalating antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide

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