Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity

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Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity is …
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scholarly articleQ13442814

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P356DOI10.1038/NN1030
P698PubMed publication ID12640458
P5875ResearchGate publication ID10854001

P50authorRobert J. HarveyQ49489445
Trevor G SmartQ64684772
Alastair M HosieQ123562002
P2093author name stringEmma L Dunne
P2860cites workCrystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptorsQ27631812
A single histidine residue is essential for zinc inhibition of GABA rho 1 receptorsQ28283686
Two gamma2L subunit domains confer low Zn2+ sensitivity to ternary GABA(A) receptorsQ28361694
Interaction of H+ and Zn2+ on recombinant and native rat neuronal GABAA receptorsQ28379393
Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channelQ28379427
Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+Q28566203
Zinc coordination sphere in biochemical zinc sites.Q30329554
Synaptically released zinc: physiological functions and pathological effects.Q30329555
Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transferQ30667258
Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation.Q31813374
Developmental change of GABA(A) receptor-mediated current in rat hippocampusQ33893372
Anxiety over GABA(A) receptor structure relieved by AChBP.Q34133813
Subunit composition, distribution and function of GABA(A) receptor subtypesQ34143787
Constructing inhibitory synapsesQ34205582
Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published]Q34429004
Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunitQ36415753
Zinc coordination, function, and structure of zinc enzymes and other proteinsQ37946601
Modulation of inhibitory and excitatory amino acid receptor ion channels by zincQ40391600
Functional domains of GABAA receptors.Q40453946
An N-terminal histidine regulates Zn(2+) inhibition on the murine GABA(A) receptor beta3 subunitQ40710238
Arg-274 and Leu-277 of the gamma-aminobutyric acid type A receptor alpha 2 subunit define agonist efficacy and potencyQ40881351
Identification of residues within GABA(A) receptor alpha subunits that mediate specific assembly with receptor beta subunits.Q40901647
From ion currents to genomic analysis: recent advances in GABAA receptor research.Q40956408
Zn2+ inhibition of recombinant GABAA receptors: an allosteric, state-dependent mechanism determined by the gamma-subunitQ41058271
Pharmacological and physiological characterization of murine homomeric beta3 GABA(A) receptorsQ41065249
Stoichiometry and assembly of a recombinant GABAA receptor subtype.Q41116066
GABAA receptors are differentially sensitive to zinc: dependence on subunit compositionQ41844887
Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segmentQ43586503
Lack of effect of mossy fiber-released zinc on granule cell GABA(A) receptors in the pilocarpine model of epilepsyQ43607853
gamma-Aminobutyric acid(A) receptor subunit expression predicts functional changes in hippocampal dentate granule cells during postnatal developmentQ43627925
Inhibitory zinc-enriched terminals in the mouse cerebellum: double-immunohistochemistry for zinc transporter 3 and glutamate decarboxylaseQ43901287
Functional consequences of the loss of high affinity agonist binding to gamma-aminobutyric acid type A receptors. Implications for receptor desensitizationQ43946810
Differential epilepsy-associated alterations in postsynaptic GABA(A) receptor function in dentate granule and CA1 neuronsQ45104103
Identification of a Zn2+ binding site on the murine GABAA receptor complex: dependence on the second transmembrane domain of beta subunits.Q48946462
GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbitalQ49124909
Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy modelQ49161890
Modulation of bistratified cell IPSPs and basket cell IPSPs by pentobarbitone sodium, diazepam and Zn2+: dual recordings in slices of adult rat hippocampus.Q51433701
A novel modulatory binding site for zinc on the GABAA receptor complex in cultured rat neuronesQ52233054
An update on GABAA receptorsQ56601749
The role of an alpha subtype M2-M3 His in regulating inhibition of GABAA receptor current by zinc and other divalent cationsQ74393183
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)362-369
P577publication date2003-04-01
P1433published inNature NeuroscienceQ1535359
P1476titleZinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity
P478volume6

Reverse relations

cites work (P2860)
Q358532202'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors
Q39647385A highly selective OFF–ON fluorescent sensor for zinc in aqueous solution and living cells
Q33850761Abnormal GABAA receptors from the human epileptic hippocampal subiculum microtransplanted to Xenopus oocytes
Q36364416Agonist-activated ion channels
Q37634832Altered Channel Conductance States and Gating of GABAA Receptors by a Pore Mutation Linked to Dravet Syndrome.
Q33574699An epilepsy-related region in the GABA(A) receptor mediates long-distance effects on GABA and benzodiazepine binding sites
Q34682246An intersubunit zinc binding site in rat P2X2 receptors
Q43054828Analysis of macroscopic ionic currents mediated by GABArho1 receptors during lanthanide modulation predicts novel states controlling channel gating
Q40897947Assembly, trafficking and function of α1β2γ2 GABAA receptors are regulated by N-terminal regions, in a subunit-specific manner.
Q35049035Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation
Q89479721Cell surface expression of homomeric GABAA receptors depends on single residues in subunit transmembrane domains
Q48882911Cell type-specific action of seizure-induced intracellular zinc accumulation in the rat hippocampus
Q37073603Cellular transport and homeostasis of essential and nonessential metals
Q40067514Co-release of inhibitory neurotransmitters in the mouse auditory midbrain
Q35165207Comparative modeling of GABA(A) receptors: limits, insights, future developments.
Q41161670Comparison of γ-Aminobutyric Acid, Type A (GABAA), Receptor αβγ and αβδ Expression Using Flow Cytometry and Electrophysiology: EVIDENCE FOR ALTERNATIVE SUBUNIT STOICHIOMETRIES AND ARRANGEMENTS
Q36131243Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population
Q41642630Dentate granule cell GABA(A) receptors in epileptic hippocampus: enhanced synaptic efficacy and altered pharmacology
Q45282611Developmental changes in expression of GABAA receptor-channels in rat intrinsic cardiac ganglion neurones
Q30491994Different forms of glycine- and GABA(A)-receptor mediated inhibitory synaptic transmission in mouse superficial and deep dorsal horn neurons
Q45136832Differential protein mobility of the gamma-aminobutyric acid, type A, receptor alpha and beta subunit channel-lining segments
Q36104192Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry
Q38966101Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
Q90436294Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel
Q37520123Endogenous zinc depresses GABAergic transmission via T-type Ca(2+) channels and broadens the time window for integration of glutamatergic inputs in dentate granule cells
Q44619363Endogenous zinc inhibits GABA(A) receptors in a hippocampal pathway
Q99711181Expression and Function of GABA Receptors in Myelinating Cells
Q90364990Expression and purification of a functional heteromeric GABAA receptor for structural studies
Q45339716Expression of gamma-aminobutyric acid receptor (subtype A) in prostate cancer
Q47987404Expression of the γ2-subunit distinguishes synaptic and extrasynaptic GABA(A) receptors in NG2 cells of the hippocampus.
Q39562897Extracellular alkalinization stimulates calcium-activated chloride conductance in cystic fibrosis human airway epithelial cells
Q48403423Extrasynaptic alphabeta subunit GABAA receptors on rat hippocampal pyramidal neurons.
Q28572529Fragrant dioxane derivatives identify beta1-subunit-containing GABAA receptors
Q35583676Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes
Q47109359GABA A Receptor Coupling Junction and Pore GABRB3 Mutations are Linked to Early-Onset Epileptic Encephalopathy
Q46266236GABA affinity shapes IPSCs in thalamic nuclei.
Q30498662GABA and glycine as neurotransmitters: a brief history
Q34059609GABA coordinates with insulin in regulating secretory function in pancreatic INS-1 β-cells
Q35262443GABA(A) receptor modulation by terpenoids from Sideritis extracts
Q36820566GABA(A) receptors: structure and function in the basal ganglia
Q86521044GABAA Receptors of Cerebellar Granule Cells in Culture: Interaction with Benzodiazepines
Q57889194GABAA receptor modulation by the volatile fractions of Sideritis species used as ‘Greek’ or ‘Turkish’ mountain tea
Q34365717GABAA receptor structure-function studies: a reexamination in light of new acetylcholine receptor structures
Q35457913GABAA receptor subunit profiles of tangentially migrating neurons derived from the medial ganglionic eminence
Q47967839Genetic and Molecular Regulation of Extrasynaptic GABA-A Receptors in the Brain: Therapeutic Insights for Epilepsy.
Q39675322High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors
Q40835327Identification of amino acids involved in histamine potentiation of GABA A receptors
Q21093378In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression
Q41335364Inhibition of the GABAA Receptor by Sulfated Neurosteroids: A Mechanistic Comparison Study between Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate
Q27675268Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent Cations
Q45922707Inhibitory transmission in locus coeruleus neurons expressing GABAA receptor epsilon subunit has a number of unique properties.
Q40648725Insights into the structural basis for zinc inhibition of the glycine receptor
Q37708070Integrated multi-ISE arrays with improved sensitivity, accuracy and precision
Q38249959Interaction of metal ions with neurotransmitter receptors and potential role in neurodiseases
Q26778336Ionotropic GABA receptor antagonism-induced adverse outcome pathways for potential neurotoxicity biomarkers
Q36393125Ligand binding and allostery can emerge simultaneously
Q38974419Mechanism of Allosteric Modulation of the Cys-loop Receptors
Q34399901Menthol enhances phasic and tonic GABAA receptor-mediated currents in midbrain periaqueductal grey neurons
Q40282817Metal-assisted channel stabilization: disposition of a single histidine on the N-terminus of alamethicin yields channels with extraordinarily long lifetimes.
Q26859850Methods for recording and measuring tonic GABAA receptor-mediated inhibition
Q36516836Modulating inhibitory ligand-gated ion channels
Q90893630Modulation of Gpr39, a G-protein coupled receptor associated with alcohol use in non-human primates, curbs ethanol intake in mice
Q48617154Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone
Q30425220Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels
Q40577117Molecular basis for modulation of recombinant alpha1beta2gamma2 GABAA receptors by protons
Q28115785Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
Q40419997Molecular determinants of glycine receptor alphabeta subunit sensitivities to Zn2+-mediated inhibition
Q46405011Molecular mechanisms supporting a paracrine role of GABA in rat adrenal medullary cells
Q36344256Neonatal epilepsy syndromes and GEFS+: mechanistic considerations
Q37320505Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability
Q35971833Neurosteroids and GABA-A Receptor Function
Q47827289Neurotoxicity of Zinc.
Q37352386Non-agonist-binding subunit interfaces confer distinct functional signatures to the alternate stoichiometries of the alpha4beta2 nicotinic receptor: an alpha4-alpha4 interface is required for Zn2+ potentiation
Q42607120Novel α1 and γ2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsy.
Q34277867Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus.
Q35177102Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes
Q44582026Pharmacology of GABA(A) receptors exhibiting different levels of spontaneous activity.
Q38079427Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review
Q50643573Pregnenolone sulphate and Zn2+ inhibit recombinant rat GABA(A) receptor through different channel property.
Q92524935Probing disrupted neurodevelopment in autism using human stem cell-derived neurons and organoids: An outlook into future diagnostics and drug development
Q28504846Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits
Q26784089Redox and trace metal regulation of ion channels in the pain pathway
Q35146447Rescue of impaired fear extinction and normalization of cortico-amygdala circuit dysfunction in a genetic mouse model by dietary zinc restriction
Q48925349Retrograde tracing of the subset of afferent connections in mouse barrel cortex provided by zincergic neurons
Q37172534Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling molecule
Q24617826SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro
Q24677049Selective block of the human 2-P domain potassium channel, TASK-3, and the native leak potassium current, IKSO, by zinc
Q39667359Snake neurotoxin α-bungarotoxin is an antagonist at native GABA(A) receptors
Q38308422Spontaneous mobility of GABAA receptor M2 extracellular half relative to noncompetitive antagonist action
Q41956571Stoichiometry of δ subunit containing GABA(A) receptors.
Q39631476Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What?
Q47678129Structural basis for GABAA receptor potentiation by neurosteroids.
Q46681409Structural determinants of benzodiazepine allosteric regulation of GABA(A) receptor currents.
Q36686927Structure, pharmacology, and function of GABAA receptor subtypes.
Q36088170Studies of ethanol actions on recombinant delta-containing gamma-aminobutyric acid type A receptors yield contradictory results
Q48361891Study of the Interaction of 1,4- and 1,5-Benzodiazepines with GABAA Receptors of Rat Cerebellum Granule Cells in Culture
Q35108146Synaptically released zinc gates long-term potentiation in fear conditioning pathways.
Q35220449Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus
Q46598639Target-dependent use of co-released inhibitory transmitters at central synapses.
Q35688528The TM2 6' position of GABA(A) receptors mediates alcohol inhibition
Q48124115The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease.
Q44873595The modeling of the structure of the cysteine-rich domain of metabotropic glutamate receptors
Q36126098The neurobiology of zinc in health and disease
Q33937098The short splice variant of the gamma 2 subunit acts as an external modulator of GABA(A) receptor function
Q37789790The structural basis of function in Cys-loop receptors.
Q24675201The zinc sensing receptor, a link between zinc and cell signaling
Q41574564Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease
Q34666487Trafficking and potential assembly patterns of epsilon-containing GABAA receptors
Q35583015Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor
Q37147577Zinc Selectively Blocks Neurosteroid-Sensitive Extrasynaptic δGABAA Receptors in the Hippocampus.
Q37887564Zinc homeostasis and signaling in health and diseases: Zinc signaling
Q42785636Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore
Q33936295Zinc inhibition of gamma-aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission
Q93339679Zinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA-A receptor-mediated tonic inhibition in the hippocampus
Q36026294Zinc-specific autometallographic in vivo selenium methods: tracing of zinc-enriched (ZEN) terminals, ZEN pathways, and pools of zinc ions in a multitude of other ZEN cells
Q35581521Zn2+ transporters and Zn2+ homeostasis in neurons
Q37040099Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABAA receptors: evidence of a novel benzodiazepine site in the α1-α1 interface

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