Regulation of Ca2+ signaling with particular focus on mast cells

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Regulation of Ca2+ signaling with particular focus on mast cells is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1615/CRITREVIMMUNOL.V29.I2.40
P932PMC publication ID2954050
P698PubMed publication ID19496745
P5875ResearchGate publication ID26267037

P2093author name stringMichael A Beaven
Hong-Tao Ma
P2860cites workIdentification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteinsQ24291460
Orai1 and STIM reconstitute store-operated calcium channel functionQ24293232
Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1Q24294877
Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 ReceptorsQ24295021
STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activationQ24295203
STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ EntryQ24297883
Orai1 is an essential pore subunit of the CRAC channelQ24300383
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutationsQ24301868
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1Q24302464
STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levelsQ24304975
Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2Q24305274
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influxQ24307461
TRPC1, a human homolog of a Drosophila store-operated channelQ24312092
trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entryQ24314989
CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entryQ24322017
A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease riskQ24336362
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membraneQ24337703
Amplification of CRAC current by STIM1 and CRACM1 (Orai1)Q24338326
STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channelsQ24544990
Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activityQ24548526
Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel componentsQ24612969
New developments in mast cell biologyQ24634390
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and toleranceQ24642248
STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channelsQ24643529
ATP-dependent adenophostin activation of inositol 1,4,5-trisphosphate receptor channel gating: kinetic implications for the durations of calcium puffs in cellsQ24644630
Role of ABCC1 in export of sphingosine-1-phosphate from mast cellsQ24671687
STIM1, an essential and conserved component of store-operated Ca2+ channel functionQ24678317
Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7Q24684596
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of OraiQ26793407
Structural changes in the calcium pump accompanying the dissociation of calciumQ27639472
Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligandQ27639992
The molecular basis for cyclopiazonic acid inhibition of the sarcoplasmic reticulum calcium pumpQ27643680
STIM1 gates TRPC channels, but not Orai1, by electrostatic interactionQ28115928
Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cellsQ28202691
RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeabilityQ28206364
Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activationQ28241052
Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathwayQ28252623
Calcium pumps of plasma membrane and cell interiorQ28257824
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseasesQ28265044
Stored Ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region: An initiation mechanism for capacitive Ca2+ entryQ28266969
Complete primary structure of a human plasma membrane Ca2+ pumpQ28281426
Transient receptor potential cation channels in diseaseQ28284143
The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitorsQ28291511
Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5Q28296901
Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kineticsQ28301371
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel functionQ28305026
BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptorQ28344730
Predetermined recruitment of calcium release sites underlies excitation-contraction coupling in rat atrial myocytesQ28346072
Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptorsQ28360565
An examination of the secretion-like coupling model for the activation of the Ca2+ release-activated Ca2+ current I(CRAC) in RBL-1 cellsQ28361709
Adenophostin A and ribophostin, but not inositol 1,4,5-trisphosphate or manno-adenophostin, activate the Ca2+ release-activated Ca2+ current, I(CRAC), in weak intracellular Ca2+ bufferQ28366293
Biphasic regulation of mitochondrial Ca2+ uptake by cytosolic Ca2+ concentrationQ28569892
Molecular cloning of two isoforms of the plasma membrane Ca2+-transporting ATPase from rat brain. Structural and functional domains exhibit similarity to Na+,K+- and other cation transport ATPasesQ28580311
IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responsesQ28586614
ATP-dependent Ca++-extrusion from human red cellsQ28609353
TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarizationQ28646918
Calcium signalingQ29617338
Localization of Ca2+ extrusion sites in pancreatic acinar cellsQ71081510
Regulation of the inositol 1,4,5-trisphosphate receptor by tyrosine phosphorylationQ71084759
Curcumin is a non-competitive and selective inhibitor of phosphorylase kinaseQ71615163
Adenophostin-medicated quantal Ca2+ release in the purified and reconstituted inositol 1,4,5-trisphosphate receptor type 1Q71940805
Adenophostins A and B: potent agonists of inositol-1,4,5-trisphosphate receptor produced by Penicillium brevicompactum. Structure elucidationQ72272371
Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells: roles of cytosolic calcium and protein tyrosine kinasesQ72550510
Calcium release-activated calcium current in rat mast cellsQ72578616
The mechanism of the calcium signal and correlation with histamine release in 2H3 cellsQ72733356
The calcium signal and phosphatidylinositol breakdown in 2H3 cellsQ72733359
Presenilin-mediated modulation of capacitative calcium entryQ73133100
Calmodulin increases the sensitivity of type 3 inositol-1,4, 5-trisphosphate receptors to Ca(2+) inhibition in human bronchial mucosal cellsQ73487502
Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neuronsQ73675821
Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumpsQ73989348
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulationQ74381752
The effect of calcium and pH on the anaphylactic reactionQ74822737
Calcium release-activated calcium current (ICRAC) is a direct target for sphingosineQ77300033
Activation of phospholipase C-Ca2+ system by sphingosine 1-phosphate in CHO cells transfected with Edg-3, a putative lipid receptorQ77937475
Formyl peptide receptor signaling in HL-60 cells through sphingosine kinaseQ77953844
Characterization of the Na+/Ca2+ exchanger on rat mast cells. Evidence for a functional role on the regulation of the cellular responseQ77961606
The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxisQ79905421
Interaction of STIM1 with endogenously expressed human canonical TRP1 upon depletion of intracellular Ca2+ storesQ79998854
Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responsesQ80146456
Primary structure, chromosomal localization and expression in immune cells of the murine ORAI and STIM genesQ80690946
Modulation of Ca2+ signaling by Na+/Ca2+ exchangers in mast cellsQ81178198
IgE receptor and signal transduction in mast cells and basophilsQ82101579
Functional stoichiometry of the unitary calcium-release-activated calcium channelQ36870049
Ca(2+) signaling in antigen receptor-activated B lymphocytesQ36877372
Calcium-dependent clustering of inositol 1,4,5-trisphosphate receptorsQ36878220
Calcium signalling in lymphocyte activation and diseaseQ36912139
Calcium signalling and cell-fate choice in B cellsQ36939905
Ca2+-store-dependent and -independent reversal of Stim1 localization and functionQ36983452
The alliance of sphingosine-1-phosphate and its receptors in immunityQ37010807
Endoplasmic reticulum/mitochondria calcium cross-talk.Q37030126
Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions.Q37035056
Cytoplasmic calcium oscillations and store-operated calcium influxQ37128185
A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 ChannelsQ37136768
Cross-linking of FcepsilonRI causes Ca2+ mobilization via a sphingosine kinase pathway in a clathrin-dependent mannerQ37145587
New developments in the signaling mechanisms of the store-operated calcium entry pathwayQ37184544
Plasma membrane Ca(2+)-ATPase: from a housekeeping function to a versatile signaling role.Q37189410
Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr2+ entry, optimal influx of Ca2+, and degranulation in a rat mast cell lineQ37189697
cADPR stimulates SERCA activity in Xenopus oocytesQ37208805
Presenilin: RIP and beyondQ37219819
Linking calcium to Abeta and Alzheimer's diseaseQ37230625
The STIM/Orai coupling machinery.Q37260035
Allergy therapy: the therapeutic potential of targeting sphingosine kinase signalling in mast cellsQ37299499
The TRPC class of ion channels: a critical review of their roles in slow, sustained increases in intracellular Ca(2+) concentrationsQ37413319
Capacitative calcium entry revisitedQ37573268
Free calcium increases explosively in activating medaka eggsQ37582105
Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ionsQ37678593
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPaseQ37726811
Distribution of inositol 1,4,5-trisphosphate receptor isoforms, SERCA isoforms and Ca2+ binding proteins in RBL-2H3 rat basophilic leukemia cellsQ38339316
Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3Q39142369
The Interrelations between the Transport of Sodium and Calcium in Mitochondria of Various Mammalian TissuesQ39178869
The Cycling of Calcium, Sodium, and Protons Across the Inner Membrane of Cardiac MitochondriaQ39226482
The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondriaQ39237126
Immunoglobulin E receptor cross-linking induces oscillations in intracellular free ionized calcium in individual tumor mast cellsQ39274476
The relationship between histamine secretion and45calcium-uptake by mast cellsQ39458453
Movement of strontium ions into mast cells and its relationship to the secretory responseQ39458465
Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica L.Q39499707
A plethora of interacting organellar Ca2+ storesQ36076045
Function and pharmacology of TRPM cation channelsQ36103564
Effect of lanthanide ions on histamine secretion from rat peritoneal mast cellsQ36127915
G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activationQ36168847
Depolarization of rat basophilic leukemia cells inhibits calcium uptake and exocytosisQ36216406
Ca2+ and Mn2+ influx through receptor-mediated activation of nonspecific cation channels in mast cellsQ36217355
Mast cell ion channelsQ36233792
STUDIES ON THE MECHANISMS OF HYPERSENSITIVITY PHENOMENA. IX. HISTAMINE RELEASE FROM HUMAN LEUKOCYTES BY RAGWEED POLLEN ANTIGEN.Q36266748
Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2bQ36328290
Interleukin 3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokinesQ36356540
Integrated signalling pathways for mast-cell activationQ36392833
Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ storesQ36405355
Calcium-dependent potentiation of store-operated calcium channels in T lymphocytesQ36411768
Calcium flickers steer cell migration.Q36421574
Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channelsQ36498394
Roles of CRAC and Cav-like channels in T cells: more than one gatekeeper?Q36502687
Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB).Q36510081
Calcium gradients and the Golgi.Q36615376
Calcium microdomains: organization and functionQ36618694
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structuresQ36628858
Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channelsQ36648633
The inositol 1,4,5-trisphosphate receptor (IP3R) and its regulators: sometimes good and sometimes bad teamworkQ36667403
The IP3 receptor/Ca2+ channel and its cellular functionQ36711229
Inositol lipids and TRPC channel activationQ36711238
New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cellsQ36724303
Role of the microtubule cytoskeleton in the function of the store-operated Ca2+ channel activator STIM1.Q36736882
Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entryQ36744229
Biochemical properties and cellular localisation of STIM proteinsQ36768776
Molecular basis of the CRAC channelQ36812479
Organization and function of TRPC channelosomesQ36814439
The complex regulatory function of the ligand-binding domain of the inositol 1,4,5-trisphosphate receptor.Q36821078
TRPC channels as STIM1-regulated store-operated channelsQ36828374
Presenilin-mediated signal transductionQ36849289
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular traffickingQ41041395
Correlating Ca2+ responses and secretion in individual RBL-2H3 mucosal mast cellsQ41066734
C3a and C5a stimulate chemotaxis of human mast cellsQ41115852
Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptorQ41205257
Calcium-dependent enhancement of depletion-activated calcium current in Jurkat T lymphocytesQ41222168
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.Q41256595
Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuliQ41257010
Interaction of cyclopiazonic acid with rat skeletal muscle sarcoplasmic reticulum vesicles. Effect on Ca2+ binding and Ca2+ permeabilityQ41267379
Ca(2+)-ATPase inhibitor, cyclopiazonic acid, releases Ca2+ from intracellular stores in RBL-2H3 mast cells and activates a Ca2+ influx pathway that is permeable to sodium and manganeseQ41328606
Activation of the mitogen-activated protein kinase/cytosolic phospholipase A2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granulesQ41345464
Physiological and molecular characterization of an IRK-type inward rectifier K+ channel in a tumour mast cell lineQ41356009
Inositol 1,4,5-trisphosphate receptor-like protein in plasmalemmal caveolae is linked to actin filamentsQ41394847
Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium.Q41442744
The role of the alkaline earth ions in anaphylactic histamine secretionQ41509431
The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cellsQ41534022
Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.Q41577951
Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptorsQ41648575
Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumpsQ41665432
Carbachol induces secretion in a mast cell line (RBL-2H3) transfected with the ml muscarinic receptor geneQ41665846
Imaging [Ca2+]i dynamics during signal transduction.Q41746305
Mast cells chemotax to laminin with enhancement after IgE-mediated activationQ41758062
The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory responseQ41852222
Localization and function of a calmodulin-apocalmodulin-binding domain in the N-terminal part of the type 1 inositol 1,4,5-trisphosphate receptor.Q41854278
A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cellsQ41989793
Antigen and thapsigargin promote influx of Ca2+ in rat basophilic RBL-2H3 cells by ostensibly similar mechanisms that allow filling of inositol 1,4,5-trisphosphate-sensitive and mitochondrial Ca2+ storesQ41996238
The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulumQ42000247
Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors.Q42001681
Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscleQ42012083
Regulation of calcium signals in the nucleus by a nucleoplasmic reticulumQ42017116
Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellumQ42150018
Structure and expression of the rat inositol 1,4,5-trisphosphate receptorQ42161930
Polarized expression of Ca2+ pumps in pancreatic and salivary gland cells. Role in initiation and propagation of [Ca2+]i wavesQ42439763
Calcium influx in a rat mast cell (RBL-2H3) line. Use of multivalent metal ions to define its characteristics and role in exocytosisQ42471726
STIM1 knockdown reveals that store-operated Ca2+ channels located close to sarco/endoplasmic Ca2+ ATPases (SERCA) pumps silently refill the endoplasmic reticulumQ42507908
Calcium-independent phosphoinositide breakdown in rat basophilic leukemia cells. Evidence for an early rise in inositol 1,4,5-trisphosphate which precedes the rise in other inositol phosphates and in cytoplasmic calciumQ42510168
Effects of cyclopiazonic acid, a novel Ca(2+)-ATPase inhibitor, on contractile responses in skinned ileal smooth muscleQ42718187
No association between CALHM1 and Alzheimer's disease riskQ42867872
Xestospongin C, a novel blocker of IP3 receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cellsQ43263790
IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cellsQ43631866
Signaling microdomains define the specificity of receptor-mediated InsP(3) pathways in neuronsQ43968738
Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasma-membrane calcium-ATPase in human T cellsQ44030411
Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapseQ44070706
Xestospongin C empties the ER calcium store but does not inhibit InsP3-induced Ca2+ release in cultured dorsal root ganglia neurones.Q44070709
Recombinant expression of the plasma membrane Na(+)/Ca(2+) exchanger affects local and global Ca(2+) homeostasis in Chinese hamster ovary cells.Q44081174
Altered Ca2+ homeostasis and impaired mitochondrial function in cardiomyopathyQ44154089
TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomachQ44358911
2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channelsQ44454777
Effects of calcium buffers and calbindin-D28k upon histamine-induced calcium oscillations and calcium waves in HeLa cellsQ44480196
Plasticity of mitochondrial calcium signalingQ44542408
The relative contributions of extracellular and intracellular calcium to secretion from tumor mast cells. Multiple effects of the proton ionophore carbonyl cyanide m-chlorophenylhydrazoneQ44568404
Synthesis and Ca2+-Mobilizing Activity of Purine-Modified Mimics of Adenophostin A: A Model for the Adenophostin−Ins(1,4,5)P3 Receptor InteractionQ44636378
Anticipating antiport in P-type ATPasesQ44637699
The mitochondrial calcium uniporter is a highly selective ion channel.Q44737530
Specific structural requirements for the inhibitory effect of thapsigargin on the Ca2+ ATPase SERCA.Q44768427
2-aminoethoxydiphenyl borate inhibits agonist-induced Ca2+ signals by blocking inositol trisphosphate formation in acutely dissociated mouse pancreatic acinar cellsQ44936899
Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cellsQ44951894
The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cellsQ44969227
Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency.Q44989706
Release of calcium from intracellular stores in rat basophilic leukemia cells monitored with the fluorescent probe chlortetracyclineQ45146470
Depletion of intracellular calcium stores activates a calcium current in mast cellsQ45345621
Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulumQ45487312
Slow calcium-dependent inactivation of depletion-activated calcium current. Store-dependent and -independent mechanisms.Q45970573
9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.Q39517485
On the mechanism of histamine release induced by thapsigargin fromThapsia garganica LQ39557061
Store-operated Ca2+ entry depends on mitochondrial Ca2+ uptakeQ39693203
2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.Q39979249
2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channelsQ39993188
Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.Q40026601
Orai1 subunit stoichiometry of the mammalian CRAC channel pore.Q40050923
All-or-none activation of CRAC channels by agonist elicits graded responses in populations of mast cellsQ40073072
Inositol trisphosphate and diacylglycerol as second messengersQ40094697
Murine ORAI2 splice variants form functional Ca2+ release-activated Ca2+ (CRAC) channelsQ40140465
CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties.Q40144074
Biochemical and functional characterization of Orai proteinsQ40172328
Ca2+ influx through CRAC channels activates cytosolic phospholipase A2, leukotriene C4 secretion, and expression of c-fos through ERK-dependent and -independent pathways in mast cellsQ40223227
A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity.Q40330987
Microtubule disruption suppresses allergic response through the inhibition of calcium influx in the mast cell degranulation pathwayQ40437971
Xestospongin B, a competitive inhibitor of IP3-mediated Ca2+ signalling in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells.Q40438708
Inhibition of the antigen-induced activation of RBL-2H3 cells by cetiedil and some of its analoguesQ40598539
Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors.Q40616004
The type 3 inositol 1,4,5-trisphosphate receptor is concentrated at the tight junction level in polarized MDCK cellsQ40646175
Expression level of the canonical transient receptor potential 3 (TRPC3) channel determines its mechanism of activationQ40657183
Determinants of adenophostin A binding to inositol trisphosphate receptorsQ40721734
Comparison of human TRPC3 channels in receptor-activated and store-operated modes. Differential sensitivity to channel blockers suggests fundamental differences in channel compositionQ40739138
2-Aminoethoxydiphenyl borate (2-APB) inhibits capacitative calcium entry independently of the function of inositol 1,4,5-trisphosphate receptorsQ40741952
Calcium puffs are generic InsP(3)-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responsesQ40764381
Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entryQ40816538
Assessment of the role of the inositol 1,4,5-trisphosphate receptor in the activation of transient receptor potential channels and store-operated Ca2+ entry channelsQ40819751
Quantification of calcium signal transmission from sarco-endoplasmic reticulum to the mitochondriaQ40837260
Stable activation of single Ca2+ release-activated Ca2+ channels in divalent cation-free solutionsQ40847413
Rapid turnover of calcium in the endoplasmic reticulum during signaling. Studies with cameleon calcium indicatorsQ40879723
Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channelsQ40896605
The characterization and quantification of antigen-induced Ca2+ oscillations in a rat basophilic leukaemia cell line (RBL-2H3).Q40900865
Convergence of Fc gamma receptor IIA and Fc gamma receptor IIIB signaling pathways in human neutrophilsQ40910968
Functional KCa3.1 K+ channels are required for human lung mast cell migrationQ40985571
Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptorQ46074332
Single-channel recording of a store-operated Ca2+ channel in Jurkat T lymphocytesQ46196366
Orai1 mediates the interaction between STIM1 and hTRPC1 and regulates the mode of activation of hTRPC1-forming Ca2+ channelsQ46470861
The second messenger linking receptor activation to internal Ca release in liverQ46568133
STIM1 regulates acidic Ca2+ store refilling by interaction with SERCA3 in human plateletsQ46624596
Cytosolic Ca2+ signals depending on the functional state of the Golgi in HeLa cellsQ46669467
2-Position base-modified analogues of adenophostin A as high-affinity agonists of the D-myo-inositol trisphosphate receptor: in vitro evaluation and molecular modeling.Q46773746
A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPasesQ48014886
Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,4,5-trisphosphate receptor.Q48115968
Adenophostins, newly discovered metabolites of Penicillium brevicompactum, act as potent agonists of the inositol 1,4,5-trisphosphate receptorQ48190922
Ca2+ entry through plasma membrane IP3 receptors.Q48546959
2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ releaseQ48605432
Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium releaseQ48738552
Adenophostin A induces spatially restricted calcium signaling in Xenopus laevis oocytesQ48913373
Effect of adenophostin A on Ca2+ entry and calcium release-activated calcium current (Icrac) in rat basophilic leukemia cells.Q50741649
The effect of mitochondrial inhibitors on calcium homeostasis in tumor mast cells.Q52449503
Alzheimer's disease: The latest suspect.Q53296268
Alzheimer's disease. Fresh evidence points to an old suspect: calcium.Q53389441
Division of labor: specialization of sphingosine kinases in mast cells.Q53564168
Localised and rapid Ca2+ micro-events in human neutrophils: conventional Ca2+ puffs and global waves without peripheral-restriction or wave cycling.Q53577175
Role of the inositol 1,4,5-trisphosphate receptor in Ca(2+) feedback inhibition of calcium release-activated calcium current (I(crac)).Q54073052
STOICHIOMETRY OF RESPIRATORY STIMULATION, ACCUMULATION OF CA++ AND PHOSPHATE, AND OXIDATIVE PHOSPHORYLATION IN RAT LIVER MITOCHONDRIAQ54501670
On the conservation of fast calcium wave speedsQ57125801
Visualization and Manipulation of Plasma Membrane-Endoplasmic Reticulum Contact Sites Indicates the Presence of Additional Molecular Components within the STIM1-Orai1 ComplexQ58451414
A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the HeartQ58717709
Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophoresQ59052484
Exocytotic fusion is activated by Rab3a peptidesQ59067325
Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphateQ59095261
Overlapping Effects of S3 Stalk Segment Mutations on the Affinity of Ca2+-ATPase (SERCA) for Thapsigargin and Cyclopiazonic Acid†Q64386183
Inhibition of the sarcoplasmic reticulum Ca2+ transport ATPase by thapsigargin at subnanomolar concentrationsQ67901188
Characterization of increased K+ permeability associated with the stimulation of receptors for immunoglobulin E on rat basophilic leukemia cellsQ67901780
Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membraneQ69517251
Thapsigargin, a novel molecular probe for studying intracellular calcium release and storageQ69741696
IgE receptor-mediated depolarization of rat basophilic leukemia cells measured with the fluorescent probe bis-oxonolQ70021958
The mechanism of anaphylactic histamine release from rabbit leucocytesQ70097130
A GTP-dependent step in the activation mechanism of capacitative calcium influxQ70500447
myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liverQ71002857
Sodium-calcium exchange and store-dependent calcium influx in transfected chinese hamster ovary cells expressing the bovine cardiac sodium-calcium exchanger. Acceleration of exchange activity in thapsigargin-treated cellsQ71058489
A model for receptor-regulated calcium entryQ29620427
The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctionsQ30480480
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta productionQ30482542
2-Aminoethoxydiphenyl borate affects the inositol 1,4,5-trisphosphate receptor, the intracellular Ca2+ pump and the non-specific Ca2+ leak from the non-mitochondrial Ca2+ stores in permeabilized A7r5 cellsQ31857290
Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptorsQ32064388
Sorting of calcium signals at the junctions of endoplasmic reticulum and mitochondriaQ32183094
Imaging asynchronous changes in intracellular Ca2+ in individual stimulated tumor mast cellsQ33560067
Calcium signaling in immune cells.Q33878792
Increased vascular smooth muscle contractility in TRPC6-/- miceQ33924920
Structural role of countertransport revealed in Ca(2+) pump crystal structure in the absence of Ca(2+)Q34078464
2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release.Q34142358
Na(+)-dependent Ca(2+) transport modulates the secretory response to the Fcepsilon receptor stimulus of mast cellsQ34174512
Our perception of the mast cell from Paul Ehrlich to now.Q34175861
Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cellsQ34182519
Modulation of mammalian inositol 1,4,5-trisphosphate receptor isoforms by calcium: a role of calcium sensor regionQ34188891
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphateQ34264314
Novel Ca2+ channels underlying transduction in Drosophila photoreceptors: implications for phosphoinositide-mediated Ca2+ mobilization.Q34306941
IP(3) receptors: the search for structure.Q34313146
Stochastic modeling of calcium in 3D geometry.Q34374152
Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effectQ34408366
Mitochondria and calcium signalingQ34441267
Oxygen-bridged dinuclear ruthenium amine complex specifically inhibits Ca2+ uptake into mitochondria in vitro and in situ in single cardiac myocytesQ34464960
Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4.Q34575244
The plasma membrane Ca2+ ATPase of animal cells: structure, function and regulation.Q34589220
Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channelsQ34621761
Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport.Q34654785
Reaction diffusion modeling of calcium dynamics with realistic ER geometryQ34698723
Functional requirement for Orai1 in store-operated TRPC1-STIM1 channelsQ34759760
Calcium signaling in lymphocytesQ34783180
Nuclear and cytosolic calcium are regulated independentlyQ34809350
Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer diseaseQ34982214
Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400.Q35534135
The action of lanthanum and manganese on anaphylactic histamine secretionQ35600213
Orai proteins interact with TRPC channels and confer responsiveness to store depletion.Q35721728
Subcellular distribution of the inositol 1,4,5-trisphosphate receptors: functional relevance and molecular determinantsQ35749144
Inositol 1,4,5-trisphosphate receptors as signal integratorsQ35799975
Lysophospholipid receptor-dependent and -independent calcium signaling.Q35839024
FcepsilonR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cellsQ35849299
Recent breakthroughs in the molecular mechanism of capacitative calcium entry (with thoughts on how we got here)Q36002742
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmast cellQ191989
P304page(s)155-186
P577publication date2009-01-01
P1433published inCritical Reviews in ImmunologyQ5186668
P1476titleRegulation of Ca2+ signaling with particular focus on mast cells
P478volume29

Reverse relations

cites work (P2860)
Q37700388A new class of human mast cell and peripheral blood basophil stabilizers that differentially control allergic mediator release
Q34895161Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33
Q35545433An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease
Q93165211Analysis of Mrgprb2 Receptor-Evoked Ca 2+ Signaling in Bone Marrow Derived (BMMC) and Peritoneal (PMC) Mast Cells of TRPC-Deficient Mice
Q36779431Aryl hydrocarbon receptor controls murine mast cell homeostasis
Q39370105Aryl hydrocarbon receptor ligand effects in RBL2H3 cells
Q34011657Btk-dependent Rac activation and actin rearrangement following FcepsilonRI aggregation promotes enhanced chemotactic responses of mast cells
Q28118474CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells
Q34567268Ca2+ waves initiate antigen-stimulated Ca2+ responses in mast cells
Q53275729Caffeic acid phenethyl ester promotes anti-inflammatory effects by inhibiting MAPK and NF-κB signaling in activated HMC-1 human mast cells.
Q38015371Cytoskeleton in mast cell signaling
Q36675623DJ-1 regulates mast cell activation and IgE-mediated allergic responses
Q55422558Elaeocarpusin Inhibits Mast Cell-Mediated Allergic Inflammation.
Q36514301IL-33 induces a hyporesponsive phenotype in human and mouse mast cells.
Q36984348IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3.
Q36717104Inhibitors of PI(4,5)P2 synthesis reveal dynamic regulation of IgE receptor signaling by phosphoinositides in RBL mast cells.
Q36100395Mast cell biology: introduction and overview
Q37457346Mechanisms of mast cell signaling in anaphylaxis
Q36627627Mitochondrial calcium uniporter inhibition attenuates mouse bone marrow-derived mast cell degranulation induced by beta-1,3-glucan
Q83742705Neuro-immune interactions in the dove brain
Q27317259PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control
Q92071923Pannexin-1 Channels Are Essential for Mast Cell Degranulation Triggered During Type I Hypersensitivity Reactions
Q37960087Pharmacology of ORAI channels as a tool to understand their physiological functions.
Q53264281Rapid IgE desensitization is antigen specific and impairs early and late mast cell responses targeting FcεRI internalization.
Q35411454Real-time imaging of Ca(2+) mobilization and degranulation in mast cells
Q36092456Regulation of mast cell responses in health and disease
Q34646844Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation
Q39355430Role of Sphingosine-1-Phosphate in Mast Cell Functions and Asthma and Its Regulation by Non-Coding RNA.
Q37626534Roles for Ca2+ mobilization and its regulation in mast cell functions: recent progress
Q41769442Roles for ca(2+) mobilization and its regulation in mast cell functions
Q28079028Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases
Q35612320Sequestration of phosphoinositides by mutated MARCKS effector domain inhibits stimulated Ca(2+) mobilization and degranulation in mast cells
Q30524729Spatiotemporal resolution of mast cell granule exocytosis reveals correlation with Ca2+ wave initiation
Q42695193Sphingosine derivatives inhibit cell signaling by electrostatically neutralizing polyphosphoinositides at the plasma membrane
Q38712363Spirodela polyrhiza extract modulates the activation of atopic dermatitis-related ion channels, Orai1 and TRPV3, and inhibits mast cell degranulation.
Q92173315Studies of novel bioprobes isolated from rare natural sources using mutant yeasts
Q40582970TRPM4-mediated control of FcεRI-evoked Ca(2+) elevation comprises enhanced plasmalemmal trafficking of TRPM4 channels in connective tissue type mast cells
Q40218625TRPM7 kinase activity regulates murine mast cell degranulation.
Q42198178The Role of TRP Proteins in Mast Cells
Q28584497The Three-Herb Formula Shuang-Huang-Lian stabilizes mast cells through activation of mitochondrial calcium uniporter
Q30010031The adaptor 3BP2 is required for early and late events in FcεRI signaling in human mast cells
Q30541177Toxoplasma gondii inhibits mast cell degranulation by suppressing phospholipase Cγ-mediated Ca(2+) mobilization

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