Preimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo?

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Preimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo? is …
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review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1046954131
P356DOI10.1007/S10815-011-9608-7
P932PMC publication ID3169679
P698PubMed publication ID21743973
P5875ResearchGate publication ID51481505

P2093author name stringAshok Agarwal
Kim Dao Ly
Zsolt Peter Nagy
P2860cites workPreimplantation genetic screening for abnormal number of chromosomes (aneuploidies) in in vitro fertilisation or intracytoplasmic sperm injectionQ24244735
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Preimplantation diagnosis for Fanconi anemia combined with HLA matchingQ28203871
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Comparison of the results of human embryo biopsy and outcome of PGD after zona drilling using acid Tyrode medium or a laserQ30976958
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Blastocyst biopsy versus cleavage stage biopsy and blastocyst transfer for preimplantation genetic diagnosis of beta-thalassaemia: a pilot studyQ33270799
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ESHRE PGD Consortium data collection IX: cycles from January to December 2006 with pregnancy follow-up to October 2007.Q33436560
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Preclinical validation of a microarray method for full molecular karyotyping of blastomeres in a 24-h protocolQ33731973
Positive outcome after preimplantation diagnosis of aneuploidy in human embryos.Q33872742
Anaphase lagging mainly explains chromosomal mosaicism in human preimplantation embryosQ75345880
Prenatal testing in ICSI pregnancies: incidence of chromosomal anomalies in 1586 karyotypes and relation to sperm parametersQ78290635
Preimplantation aneuploidy screening using comparative genomic hybridization or fluorescence in situ hybridization of embryos from patients with recurrent implantation failureQ79160322
Application of three-dimensional fluorescence in situ hybridization to human preimplantation genetic diagnosisQ79806042
Comparison of the aneuploidy frequency in embryos derived from testicular sperm extraction in obstructive and non-obstructive azoospermic menQ80087580
Nuclear chromosomal localization in human preimplantation embryos: correlation with aneuploidy and embryo morphologyQ80425448
Preimplantation genetic screening in women of advanced maternal age caused a decrease in clinical pregnancy rate: a randomized controlled trialQ81533938
Perspectives on the efficacy and indications for preimplantation genetic screening: where are we now?Q82635497
Embryo biopsy: the fate of abnormal pronuclear embryosQ82954112
Successful pregnancies after application of array-comparative genomic hybridization in PGS-aneuploidy screeningQ82954172
Pronuclear morphology differs between women more than 38 and women less than 30 years of ageQ83504889
ACOG Committee Opinion No. 430: preimplantation genetic screening for aneuploidyQ83507685
The importance of good practice in preimplantation genetic screening: critical viewpointsQ83880741
The analysis of one or two blastomeres for PGD using fluorescence in-situ hybridizationQ83994647
Two cases of trisomy 16 mosaicism ascertained postnatallyQ84077719
The relationship between blastocyst morphology, chromosomal abnormality, and embryo genderQ84384005
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ESHRE PGD Consortium/Embryology Special Interest Group--best practice guidelines for polar body and embryo biopsy for preimplantation genetic diagnosis/screening (PGD/PGS)Q85239152
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ESHRE PGD consortium best practice guidelines for amplification-based PGDQ85239160
Preimplantation diagnosis for aneuploidies in patients undergoing in vitro fertilization with a poor prognosis: identification of the categories for which it should be proposed.Q33880192
SNP microarray-based 24 chromosome aneuploidy screening demonstrates that cleavage-stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocystsQ34007983
Sperm centriole disfunction and sperm immotilityQ34034051
Analysis of the first polar body: preconception genetic diagnosisQ34278766
The use of first polar bodies for preimplantation diagnosis of aneuploidyQ34303308
Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplificationQ34321635
Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial.Q34357019
Single-embryo transferQ34419458
Cost-effectiveness of in vitro fertilizationQ34419469
Preimplantation genetic diagnosis reduces pregnancy loss in women aged 35 years and older with a history of recurrent miscarriages.Q34440975
Fluorescence in situ hybridization reanalysis of day-6 human blastocysts diagnosed with aneuploidy on day 3.Q34465927
Pregnancies and live births after trophectoderm biopsy and preimplantation genetic testing of human blastocystsQ34477292
Molecular diagnostics in preimplantation genetic diagnosisQ34516018
Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stageQ34517295
Potential significance of genomic imprinting defects for reproduction and assisted reproductive technologyQ34546139
Accurate single cell 24 chromosome aneuploidy screening using whole genome amplification and single nucleotide polymorphism microarraysQ34617227
Sex matters in meiosisQ34699921
Preimplantation diagnosis for diseases with genetic predisposition and nondisease testingQ34884761
The likelihood of live birth and multiple birth after single versus double embryo transfer at the cleavage stage: a systematic review and meta-analysisQ34981324
Current features of preimplantation genetic diagnosis.Q35019154
The basis and significance of pre–patterning in mammalsQ35213661
First-meiotic-division nondisjunction in human oocytesQ35248934
Multiple births from assisted reproductive technologies: a challenge that must be met.Q35705536
Association between nondisjunction and maternal age in meiosis-II human oocytesQ35882916
Different probe combinations for assessment of postzygotic chromosomal imbalances in human embryosQ36271289
Mechanisms of aneuploidy induction in human oogenesis and early embryogenesisQ36271546
Chromosome abnormalities and their relationship to morphology and development of human embryosQ36396448
Preimplantation genetic diagnosis: an overview of socio-ethical and legal considerationsQ36489195
PGD for aneuploidy screening: an expensive hoax?Q36644702
Reevaluation of the roles of luteinizing hormone and follicle-stimulating hormone in the ovulatory processQ36832052
Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with age.Q37033768
Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH.Q37091050
Spermiogenesis and DNA repair: a possible etiology of human infertility and genetic disordersQ37187725
IVF/ICSI with or without preimplantation genetic screening for aneuploidy in couples without genetic disorders: a systematic review and meta-analysisQ37284506
First unaffected pregnancy using preimplantation genetic diagnosis for sickle cell anemiaQ48918099
Effects of profound suppression of luteinizing hormone during ovarian stimulation on follicular activity, oocyte and embryo function in cycles stimulated with purified follicle stimulating hormoneQ48932629
Pronuclear morphology predicts embryo development and chromosome constitutionQ49265805
Does PGD for aneuploidy screening change the selection of embryos derived from testicular sperm extraction in obstructive and non-obstructive azoospermic men?Q50109837
Oocyte euploidy, pronuclear zygote morphology and embryo chromosomal complement.Q50645612
Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial.Q50646619
Cytogenetic analysis of human oocytes remaining unfertilized after intracytoplasmic sperm injection.Q50650884
Wide range of chromosome abnormalities in the embryos of young egg donors.Q50651270
Evidence of a high proportion of premature unbalanced separation of sister chromatids in the first polar bodies of women of advanced age.Q50653770
The fate of mosaic aneuploid embryos during mouse development.Q50654709
In vitro oocyte maturation and subsequent delayed fertilization is associated with increased embryo aneuploidy.Q50656699
Karyotyping of human oocytes by cenM-FISH, a new 24-colour centromere-specific technique.Q50658208
Reliability of comparative genomic hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes.Q50672829
Elective single embryo transfer: the value of cryopreservation.Q50715065
Birth of healthy children after preimplantation diagnosis of common aneuploidies by polar body fluorescent in situ hybridization analysis. Preimplantation Genetics Group.Q50761621
Assessment of numeric abnormalities of X, Y, 18, and 16 chromosomes in preimplantation human embryos before transfer.Q50762701
Preimplantation genetic diagnosis principles and ethics.Q51094453
Preimplantation genetic screening does not improve delivery rate in women under the age of 36 following single-embryo transfer.Q51678170
The impact of LH-containing gonadotropins on diploidy rates in preimplantation embryos: long protocol stimulation.Q51720336
Different embryonic development after blastomere biopsy for preimplantation genetic diagnosis, observed by time-lapse imaging.Q51936953
Preimplantation aneuploid embryos undergo self-correction in correlation with their developmental potential.Q51948445
Diagnostic efficiency, embryonic development and clinical outcome after the biopsy of one or two blastomeres for preimplantation genetic diagnosis.Q51968796
Neurological sequelae in children born after in-vitro fertilisation: a population-based study.Q52123623
Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities.Q52206925
Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos.Q53293819
ESHRE PGD consortium best practice guidelines for organization of a PGD centre for PGD/preimplantation genetic screening.Q53294162
The impact of LH-containing gonadotropin stimulation on euploidy rates in preimplantation embryos: antagonist cycles.Q53455830
What next for preimplantation genetic screening (PGS)? Experience with blastocyst biopsy and testing for aneuploidy.Q53472614
Maternal age, morphology, development and chromosome abnormalities in over 6000 cleavage-stage embryos.Q53552393
Embryo morphology and development are dependent on the chromosomal complement.Q53586766
Is the plane of first cleavage related to the point of sperm entry in the mouse?Q53656985
Self-correction of chromosomally abnormal embryos in culture and implications for stem cell production.Q54632231
Guidelines for good practice in PGD: programme requirements and laboratory quality assurance.Q54714247
Identification of differentially expressed mRNAs in bovine preimplantation embryos.Q54785366
The combination of polar body and embryo biopsy does not affect embryo viabilityQ57001976
Clinical application of comprehensive chromosomal screening at the blastocyst stageQ57779161
Selection of embryos by morphology is less effective than by a combination of aneuploidy testing and morphology observationsQ57779196
Increased efficiency of preimplantation genetic diagnosis for infertility using “no result rescue”Q57779224
Removal of 2 cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests that are used to enhance implantation ratesQ57779232
Preimplantation genetic diagnosis significantly reduces pregnancy loss in infertile couples: a multicenter studyQ57779247
Chromosomal abnormalities in embryos derived from testicular sperm extractionQ57779314
Sperm quality may adversely affect the chromosome constitution of embryos that result from intracytoplasmic sperm injectionQ57779420
Sperm chromosomal abnormalities are linked to sperm morphologic deformitiesQ58226668
In Vitro Fertilization with Preimplantation Genetic ScreeningQ59782826
Preimplantation genetic diagnosis. In situ hybridization as a tool for analysisQ68089002
Diagnosis of major chromosome aneuploidies in human preimplantation embryosQ72347419
Chromosome mosaicism in human embryosQ72365258
Detection of DNA copy number changes in human endometriosis by comparative genomic hybridizationQ73274297
Chromosome analysis of blastomeres from human embryos by using comparative genomic hybridizationQ73621662
Improved implantation after preimplantation genetic diagnosis of aneuploidyQ73832631
Elective single embryo transfer: a 6-year progressive implementation of 784 single blastocyst transfers and the influence of payment method on patient choiceQ37314404
Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes.Q37466984
Preimplantation genetic diagnosis: state of the art.Q37467883
Centrioles in the beginning of human developmentQ37523526
Current trends, biological foundations and future prospects of oocyte and embryo cryopreservationQ37539037
Uniparental disomy and the phenotype of mosaic trisomy 20: a new case and review of the literatureQ37564857
Attitudes towards single embryo transfer, twin and higher order pregnancies in patients undergoing infertility treatment: a reviewQ37689134
Embryo aneuploidy and the role of morphological and genetic screeningQ37778166
Sequential FISH analysis using competitive displacement of labelled peptide nucleic acid probes for eight chromosomes in human blastomeresQ38331564
Fluorescence in situ hybridization analysis of human oocytes: advantages of a double-labeling procedureQ38476905
Reliability of short comparative genomic hybridization in fibroblasts and blastomeres for a comprehensive aneuploidy screening: first clinical applicationQ39701820
What next for preimplantation genetic screening (PGS)? A position statement from the ESHRE PGD Consortium Steering CommitteeQ39904266
Genetic testing of embryos: practices and perspectives of US in vitro fertilization clinicsQ40194292
Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trialQ40254344
Construction of an evidence-based integrated morphology cleavage embryo score for implantation potential of embryos scored and transferred on day 2 after oocyte retrieval.Q40271383
The incidence, origin, and etiology of aneuploidyQ41080526
Oocyte polarity and cell determination in early mammalian embryosQ41658998
An estimate of the cost of in vitro fertilization services in the United States in 1995Q42680644
Suppression of LH during ovarian stimulation: analysing threshold values and effects on ovarian response and the outcome of assisted reproduction in down-regulated women stimulated with recombinant FSH.Q43688571
Cytogenetic analysis of giant oocytes and zygotes to assess their relevance for the development of digynic triploidyQ44119052
Predivision in human oocytes at meiosis I: a mechanism for trisomy formation in man.Q44158682
Experimental analysis of second cleavage in the mouseQ44232641
Preimplantation genetic screening for aneuploidy of embryos after in vitro fertilization in women aged at least 35 years: a prospective randomized trialQ44316456
Blastomere fixation techniques and risk of misdiagnosis for preimplantation genetic diagnosis of aneuploidyQ44412800
No beneficial effect of preimplantation genetic screening in women of advanced maternal age with a high risk for embryonic aneuploidyQ44885065
Day-3 embryo morphology predicts euploidy among older subjects.Q45950670
Ovarian stimulation and the risk of aneuploid conceptionsQ45984200
Preimplantation genetic screening in older women: a cost-effectiveness analysis.Q46027773
Accuracy of FISH analysis in predicting chromosomal status in patients undergoing preimplantation genetic diagnosisQ46184860
Morbidity in a Danish national cohort of 472 IVF/ICSI twins, 1132 non-IVF/ICSI twins and 634 IVF/ICSI singletons: health-related and social implications for the children and their familiesQ46349074
Differences in chromosome susceptibility to aneuploidy and survival to first trimesterQ47226926
ESHRE PGD Consortium 'Best practice guidelines for clinical preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS)'.Q47626578
Comprehensive chromosome screening of polar bodies and blastocysts from couples experiencing repeated implantation failureQ48718141
Prognostic value of sperm fluorescence in situ hybridization analysis over PGD.Q48725524
Comprehensive molecular cytogenetic analysis of the human blastocyst stageQ48743163
Reproductive oocyte/embryo genetic analysis: comparison between fluorescence in-situ hybridization and comparative genomic hybridizationQ48783381
The influence of sperm morphology on preimplantation genetic diagnosis cycles outcomeQ48784587
Ovarian response and pregnancy outcome in poor-responder women: a randomized controlled trial on the effect of luteinizing hormone supplementation on in vitro fertilization cyclesQ48792044
Lack of association between polycystic ovary syndrome and embryonic aneuploidyQ48795180
Duplication of the sperm genome by human androgenetic embryo production: towards testing the paternal genome prior to fertilizationQ48795367
Aneuploidy study of human oocytes first polar body comparative genomic hybridization and metaphase II fluorescence in situ hybridization analysis.Q48808126
Chromosome abnormalities in 1255 cleavage-stage human embryosQ48827038
Assessment of beta-HCG, beta-LH mRNA and ploidy in individual human blastomeresQ48846627
First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidyQ48852165
Mechanisms of non-disjunction in human female meiosis: the co-existence of two modes of malsegregation evidenced by the karyotyping of 1397 in-vitro unfertilized oocytesQ48854145
Spectral karyotyping of fresh, non-inseminated oocytesQ48859511
P433issue9
P304page(s)833-849
P577publication date2011-07-09
P1433published inJournal of Assisted Reproduction and GeneticsQ15755113
P1476titlePreimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo?
P478volume28

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cites work (P2860)
Q36434649A review of, and commentary on, the ongoing second clinical introduction of preimplantation genetic screening (PGS) to routine IVF practice
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